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Frequent rearrangements of chromosomes 1, 7, and 8 in primary liver cancer

Parada, Luis Antonio; Hallén, Magnus LU ; Tranberg, Karl-Göran LU ; Hagerstrand, Inga; Bondeson, Lennart LU ; Mitelman, Felix LU and Johansson, Bertil LU (1998) In Genes, Chromosomes and Cancer 23(1). p.26-35
Abstract
Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detected in four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, and 8 and chromosome bands 1p36, 1q25, 3q10, 5q13, 6p10, 7p15, 7q22, 7q32, 8q10, 8q13, 14q10, and 17p11. Frequent genomic imbalances included gains of 1q, 3q, 6p, 7p, and 8q and losses of 1p, 8p, 10q, 14p, 17p, and 19p. A compilation of findings for all 19 cytogenetically abnormal PLCs reported to date, including the present cases, reveals that... (More)
Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detected in four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, and 8 and chromosome bands 1p36, 1q25, 3q10, 5q13, 6p10, 7p15, 7q22, 7q32, 8q10, 8q13, 14q10, and 17p11. Frequent genomic imbalances included gains of 1q, 3q, 6p, 7p, and 8q and losses of 1p, 8p, 10q, 14p, 17p, and 19p. A compilation of findings for all 19 cytogenetically abnormal PLCs reported to date, including the present cases, reveals that structural aberrations particularly affect 1p11, 1p22, 1p32, 1p34, 1p36, 1q25, 7p15, 7q22, 8q10, 8q13, 14q10, 16q24, and 17p11, and that the abnormalities frequently result in overrepresentation of 1q, 3q, 6p, 7p10-14, 8q, and 17q and underrepresentation of 1p34-36, 6q27, 7q32-qter, 8p, 13p, 14p, 16q24, and 17p. These genomic regions are likely to harbor genes of importance in hepatocarcinogenesis, and the present cytogenetic mapping may hence be of value for further molecular genetic investigations of PLC. (Less)
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keywords
Karyotyping, Humans, Female, Pair 8/ genetics, Pair 7/ genetics, Pair 1/ genetics, Human, Chromosomes, 80 and over, Aged, Adolescent, Adult, Liver Neoplasms/ genetics/pathology, Male, Middle Aged, Translocation, Genetic
in
Genes, Chromosomes and Cancer
volume
23
issue
1
pages
26 - 35
publisher
John Wiley & Sons
external identifiers
  • scopus:0031880106
ISSN
1045-2257
language
English
LU publication?
yes
id
13fafdc1-41dd-494c-baaf-4dae947ba75b (old id 3052301)
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http://www.ncbi.nlm.nih.gov/pubmed/9713994
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1098-2264(199809)23:1%3C26::AID-GCC5%3E3.0.CO;2-8/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+11+May+from+10%3A00-12%3A00+BST+(05%3A00-07%3A00+EDT)+for+essential+maintenance
date added to LUP
2013-05-07 14:19:10
date last changed
2017-04-16 04:20:12
@article{13fafdc1-41dd-494c-baaf-4dae947ba75b,
  abstract     = {Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detected in four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, and 8 and chromosome bands 1p36, 1q25, 3q10, 5q13, 6p10, 7p15, 7q22, 7q32, 8q10, 8q13, 14q10, and 17p11. Frequent genomic imbalances included gains of 1q, 3q, 6p, 7p, and 8q and losses of 1p, 8p, 10q, 14p, 17p, and 19p. A compilation of findings for all 19 cytogenetically abnormal PLCs reported to date, including the present cases, reveals that structural aberrations particularly affect 1p11, 1p22, 1p32, 1p34, 1p36, 1q25, 7p15, 7q22, 8q10, 8q13, 14q10, 16q24, and 17p11, and that the abnormalities frequently result in overrepresentation of 1q, 3q, 6p, 7p10-14, 8q, and 17q and underrepresentation of 1p34-36, 6q27, 7q32-qter, 8p, 13p, 14p, 16q24, and 17p. These genomic regions are likely to harbor genes of importance in hepatocarcinogenesis, and the present cytogenetic mapping may hence be of value for further molecular genetic investigations of PLC.},
  author       = {Parada, Luis Antonio and Hallén, Magnus and Tranberg, Karl-Göran and Hagerstrand, Inga and Bondeson, Lennart and Mitelman, Felix and Johansson, Bertil},
  issn         = {1045-2257},
  keyword      = {Karyotyping,Humans,Female,Pair 8/ genetics,Pair 7/ genetics,Pair 1/ genetics,Human,Chromosomes,80 and over,Aged,Adolescent,Adult,Liver Neoplasms/ genetics/pathology,Male,Middle Aged,Translocation,Genetic},
  language     = {eng},
  number       = {1},
  pages        = {26--35},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {Frequent rearrangements of chromosomes 1, 7, and 8 in primary liver cancer},
  volume       = {23},
  year         = {1998},
}