Frequent rearrangements of chromosomes 1, 7, and 8 in primary liver cancer
(1998) In Genes, Chromosomes and Cancer 23(1). p.26-35- Abstract
- Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detected in four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, and 8 and chromosome bands 1p36, 1q25, 3q10, 5q13, 6p10, 7p15, 7q22, 7q32, 8q10, 8q13, 14q10, and 17p11. Frequent genomic imbalances included gains of 1q, 3q, 6p, 7p, and 8q and losses of 1p, 8p, 10q, 14p, 17p, and 19p. A compilation of findings for all 19 cytogenetically abnormal PLCs reported to date, including the present cases, reveals that... (More)
- Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detected in four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, and 8 and chromosome bands 1p36, 1q25, 3q10, 5q13, 6p10, 7p15, 7q22, 7q32, 8q10, 8q13, 14q10, and 17p11. Frequent genomic imbalances included gains of 1q, 3q, 6p, 7p, and 8q and losses of 1p, 8p, 10q, 14p, 17p, and 19p. A compilation of findings for all 19 cytogenetically abnormal PLCs reported to date, including the present cases, reveals that structural aberrations particularly affect 1p11, 1p22, 1p32, 1p34, 1p36, 1q25, 7p15, 7q22, 8q10, 8q13, 14q10, 16q24, and 17p11, and that the abnormalities frequently result in overrepresentation of 1q, 3q, 6p, 7p10-14, 8q, and 17q and underrepresentation of 1p34-36, 6q27, 7q32-qter, 8p, 13p, 14p, 16q24, and 17p. These genomic regions are likely to harbor genes of importance in hepatocarcinogenesis, and the present cytogenetic mapping may hence be of value for further molecular genetic investigations of PLC. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3052301
- author
- Parada, Luis Antonio ; Hallén, Magnus LU ; Tranberg, Karl-Göran LU ; Hagerstrand, Inga ; Bondeson, Lennart LU ; Mitelman, Felix LU and Johansson, Bertil LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Karyotyping, Humans, Female, Pair 8/ genetics, Pair 7/ genetics, Pair 1/ genetics, Human, Chromosomes, 80 and over, Aged, Adolescent, Adult, Liver Neoplasms/ genetics/pathology, Male, Middle Aged, Translocation, Genetic
- in
- Genes, Chromosomes and Cancer
- volume
- 23
- issue
- 1
- pages
- 26 - 35
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0031880106
- ISSN
- 1045-2257
- language
- English
- LU publication?
- yes
- id
- 13fafdc1-41dd-494c-baaf-4dae947ba75b (old id 3052301)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/9713994
- http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1098-2264(199809)23:1%3C26::AID-GCC5%3E3.0.CO;2-8/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+11+May+from+10%3A00-12%3A00+BST+(05%3A00-07%3A00+EDT)+for+essential+maintenance
- date added to LUP
- 2016-04-04 07:36:48
- date last changed
- 2022-01-29 02:22:03
@article{13fafdc1-41dd-494c-baaf-4dae947ba75b, abstract = {{Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detected in four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, and 8 and chromosome bands 1p36, 1q25, 3q10, 5q13, 6p10, 7p15, 7q22, 7q32, 8q10, 8q13, 14q10, and 17p11. Frequent genomic imbalances included gains of 1q, 3q, 6p, 7p, and 8q and losses of 1p, 8p, 10q, 14p, 17p, and 19p. A compilation of findings for all 19 cytogenetically abnormal PLCs reported to date, including the present cases, reveals that structural aberrations particularly affect 1p11, 1p22, 1p32, 1p34, 1p36, 1q25, 7p15, 7q22, 8q10, 8q13, 14q10, 16q24, and 17p11, and that the abnormalities frequently result in overrepresentation of 1q, 3q, 6p, 7p10-14, 8q, and 17q and underrepresentation of 1p34-36, 6q27, 7q32-qter, 8p, 13p, 14p, 16q24, and 17p. These genomic regions are likely to harbor genes of importance in hepatocarcinogenesis, and the present cytogenetic mapping may hence be of value for further molecular genetic investigations of PLC.}}, author = {{Parada, Luis Antonio and Hallén, Magnus and Tranberg, Karl-Göran and Hagerstrand, Inga and Bondeson, Lennart and Mitelman, Felix and Johansson, Bertil}}, issn = {{1045-2257}}, keywords = {{Karyotyping; Humans; Female; Pair 8/ genetics; Pair 7/ genetics; Pair 1/ genetics; Human; Chromosomes; 80 and over; Aged; Adolescent; Adult; Liver Neoplasms/ genetics/pathology; Male; Middle Aged; Translocation; Genetic}}, language = {{eng}}, number = {{1}}, pages = {{26--35}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Genes, Chromosomes and Cancer}}, title = {{Frequent rearrangements of chromosomes 1, 7, and 8 in primary liver cancer}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed/9713994}}, volume = {{23}}, year = {{1998}}, }