Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.
(2013) In Contact Dermatitis 68(1). p.50-53- Abstract
- Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly... (More)
- Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series. (Less)
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https://lup.lub.lu.se/record/3161103
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dose, contact allergy, false-negative, formaldehyde, micropipette, patch, test
- in
- Contact Dermatitis
- volume
- 68
- issue
- 1
- pages
- 50 - 53
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000312309300007
- pmid:23035891
- scopus:84870949200
- pmid:23035891
- ISSN
- 0105-1873
- DOI
- 10.1111/j.1600-0536.2012.02169.x
- language
- English
- LU publication?
- yes
- id
- 3053a59e-805c-4e66-b6d0-ce7ac76f536d (old id 3161103)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23035891?dopt=Abstract
- date added to LUP
- 2016-04-01 10:18:04
- date last changed
- 2022-06-01 03:45:38
@article{3053a59e-805c-4e66-b6d0-ce7ac76f536d, abstract = {{Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.}}, author = {{Pontén, Ann and Aalto-Korte, Kristiina and Agner, Tove and Andersen, Klaus E and Giménez-Arnau, Ana M and Gonçalo, Margarida and Goossens, An and Johansen, Jeanne D and Le Coz, Christophe J and Maibach, Howard I and Rustemeyer, Thomas and White, Ian R and Bruze, Magnus}}, issn = {{0105-1873}}, keywords = {{dose; contact allergy; false-negative; formaldehyde; micropipette; patch; test}}, language = {{eng}}, number = {{1}}, pages = {{50--53}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.}}, url = {{http://dx.doi.org/10.1111/j.1600-0536.2012.02169.x}}, doi = {{10.1111/j.1600-0536.2012.02169.x}}, volume = {{68}}, year = {{2013}}, }