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Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.

Pontén, Ann LU ; Aalto-Korte, Kristiina; Agner, Tove; Andersen, Klaus E; Giménez-Arnau, Ana M; Gonçalo, Margarida; Goossens, An; Johansen, Jeanne D; Le Coz, Christophe J and Maibach, Howard I, et al. (2013) In Contact Dermatitis 68(1). p.50-53
Abstract
Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly... (More)
Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dose, contact allergy, false-negative, formaldehyde, micropipette, patch, test
in
Contact Dermatitis
volume
68
issue
1
pages
50 - 53
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000312309300007
  • pmid:23035891
  • scopus:84870949200
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2012.02169.x
language
English
LU publication?
yes
id
3053a59e-805c-4e66-b6d0-ce7ac76f536d (old id 3161103)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23035891?dopt=Abstract
date added to LUP
2012-11-01 14:33:59
date last changed
2019-05-14 01:15:06
@article{3053a59e-805c-4e66-b6d0-ce7ac76f536d,
  abstract     = {Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p &lt; 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.},
  author       = {Pontén, Ann and Aalto-Korte, Kristiina and Agner, Tove and Andersen, Klaus E and Giménez-Arnau, Ana M and Gonçalo, Margarida and Goossens, An and Johansen, Jeanne D and Le Coz, Christophe J and Maibach, Howard I and Rustemeyer, Thomas and White, Ian R and Bruze, Magnus},
  issn         = {0105-1873},
  keyword      = {dose,contact allergy,false-negative,formaldehyde,micropipette,patch,test},
  language     = {eng},
  number       = {1},
  pages        = {50--53},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2012.02169.x},
  volume       = {68},
  year         = {2013},
}