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Amble FR, Lindberg SOH, McCaffrey TV, Runer T. Mucociliary function and endothelins 1, 2, and 3. Otolaryngol Head Neck Surg 1993;109:634-45.

Amble, F R; Lindberg, Sven LU ; McCaffrey, TV and Runer, T (1993) In Otolaryngology and Head and Neck Surgery 109(4). p.45-634
Abstract
Endothelins are recently discovered peptides that cause vasoconstriction and bronchoconstriction. The significance to the mucociliary system of endothelins (ET) 1, 2 and 3 in upper as well as lower airways has not yet been clarified. Effects of these active peptides were investigated, combining both in vitro and in vivo rabbit models of mucociliary activity from the maxillary sinus and the trachea. The studies were performed using computerized photometric microscopy. Immunohistologic staining procedures were used to determine the presence of endothelins in sinus and trachea epithelium. Significant effects on mucociliary activity were noted for ET-1, -2, and -3 in vitro as well as in vivo. All endothelins were noted to accelerate... (More)
Endothelins are recently discovered peptides that cause vasoconstriction and bronchoconstriction. The significance to the mucociliary system of endothelins (ET) 1, 2 and 3 in upper as well as lower airways has not yet been clarified. Effects of these active peptides were investigated, combining both in vitro and in vivo rabbit models of mucociliary activity from the maxillary sinus and the trachea. The studies were performed using computerized photometric microscopy. Immunohistologic staining procedures were used to determine the presence of endothelins in sinus and trachea epithelium. Significant effects on mucociliary activity were noted for ET-1, -2, and -3 in vitro as well as in vivo. All endothelins were noted to accelerate mucociliary activity of both sinus and tracheal mucosa. The effects of endothelins were greater in the sinus than in the trachea. In vitro studies using the calcium blocker nifedipine and the cyclooxygenase inhibitor diclofenac indicated that the mechanism of action involves an intermediary prostaglandin pathway but is independent of release of intracellular calcium. These results were confirmed using ET-1 in vivo. Immunohistochemical staining showed endothelin to be present in both maxillary and tracheal epithelium of the rabbit. We conclude that endothelins have significant mucociliary stimulatory effects and that the presence of endothelins in normal mucosa indicates a potentially important role in respiratory homeostasis as well as inflammatory conditions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Otolaryngology and Head and Neck Surgery
volume
109
issue
4
pages
45 - 634
publisher
Mosby
ISSN
0194-5998
language
English
LU publication?
yes
id
6010d02d-af01-48eb-990c-1158b442dd44 (old id 30573)
date added to LUP
2007-06-15 15:50:29
date last changed
2016-04-16 05:04:59
@article{6010d02d-af01-48eb-990c-1158b442dd44,
  abstract     = {Endothelins are recently discovered peptides that cause vasoconstriction and bronchoconstriction. The significance to the mucociliary system of endothelins (ET) 1, 2 and 3 in upper as well as lower airways has not yet been clarified. Effects of these active peptides were investigated, combining both in vitro and in vivo rabbit models of mucociliary activity from the maxillary sinus and the trachea. The studies were performed using computerized photometric microscopy. Immunohistologic staining procedures were used to determine the presence of endothelins in sinus and trachea epithelium. Significant effects on mucociliary activity were noted for ET-1, -2, and -3 in vitro as well as in vivo. All endothelins were noted to accelerate mucociliary activity of both sinus and tracheal mucosa. The effects of endothelins were greater in the sinus than in the trachea. In vitro studies using the calcium blocker nifedipine and the cyclooxygenase inhibitor diclofenac indicated that the mechanism of action involves an intermediary prostaglandin pathway but is independent of release of intracellular calcium. These results were confirmed using ET-1 in vivo. Immunohistochemical staining showed endothelin to be present in both maxillary and tracheal epithelium of the rabbit. We conclude that endothelins have significant mucociliary stimulatory effects and that the presence of endothelins in normal mucosa indicates a potentially important role in respiratory homeostasis as well as inflammatory conditions.},
  author       = {Amble, F R and Lindberg, Sven and McCaffrey, TV and Runer, T},
  issn         = {0194-5998},
  language     = {eng},
  number       = {4},
  pages        = {45--634},
  publisher    = {Mosby},
  series       = {Otolaryngology and Head and Neck Surgery},
  title        = {Amble FR, Lindberg SOH, McCaffrey TV, Runer T. Mucociliary function and endothelins 1, 2, and 3. Otolaryngol Head Neck Surg 1993;109:634-45.},
  volume       = {109},
  year         = {1993},
}