Advanced

C-erbB2, p27 and G1/S aberrations in human primary breast cancer

Loden, M; Perris, F; Nielsen, NH; Emdin, SO and Landberg, Göran LU (2003) In Anticancer Research 23(3A). p.2053-2061
Abstract
Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with... (More)
Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with proliferation. There was, nevertheless, an association between c-erbB2 and proliferation in certain subtypes of breast cancer, as in oestrogen-receptor-positive e tumours, tumours with high cyclin D1 and in tumours with an overall linear pRb pathway, i.e. tumours with a preserved linearity between cyclin D1, pRb phosphorylation and proliferation. Conclusion: Our results suggest that c-erbB2 may have alternative functions in different subtypes of breast cancer, and further stress that c-erbB2, in addition to promoting proliferation, also functions through other mechanisms in breast cancer. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
proliferation, pRb pathway, cyclins, p27, breast cancer, c-erbB2
in
Anticancer Research
volume
23
issue
3A
pages
2053 - 2061
publisher
International Institute of Cancer Research
external identifiers
  • wos:000184359100009
  • scopus:0041304766
ISSN
1791-7530
language
English
LU publication?
yes
id
0eae8cb9-97e8-4c6c-8e71-0464a32b7d2c (old id 305807)
date added to LUP
2007-09-17 15:13:55
date last changed
2018-05-29 09:36:18
@article{0eae8cb9-97e8-4c6c-8e71-0464a32b7d2c,
  abstract     = {Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with proliferation. There was, nevertheless, an association between c-erbB2 and proliferation in certain subtypes of breast cancer, as in oestrogen-receptor-positive e tumours, tumours with high cyclin D1 and in tumours with an overall linear pRb pathway, i.e. tumours with a preserved linearity between cyclin D1, pRb phosphorylation and proliferation. Conclusion: Our results suggest that c-erbB2 may have alternative functions in different subtypes of breast cancer, and further stress that c-erbB2, in addition to promoting proliferation, also functions through other mechanisms in breast cancer.},
  author       = {Loden, M and Perris, F and Nielsen, NH and Emdin, SO and Landberg, Göran},
  issn         = {1791-7530},
  keyword      = {proliferation,pRb pathway,cyclins,p27,breast cancer,c-erbB2},
  language     = {eng},
  number       = {3A},
  pages        = {2053--2061},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {C-erbB2, p27 and G1/S aberrations in human primary breast cancer},
  volume       = {23},
  year         = {2003},
}