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Psychometric properties of the disease-specific health-related quality of life instrument VascuQoL in a Swedish setting

Nordanstig, Joakim ; Karlsson, Jan ; Pettersson, Monica and Wann-Hansson, Christine LU (2012) In Health and Quality of Life Outcomes 10.
Abstract
Background: Traditional outcome measures in peripheral arterial disease (PAD) provide insufficient information regarding patient benefit. It has therefore been suggested to add patient-reported outcome measures. The main aim of this study was to validate the Swedish Vascular Quality of Life questionnaire (VascuQoL) version, a patient-reported PAD-specific health-related quality of life (HRQoL) instrument. Methods: Two-hundred PAD patients were consecutively recruited from two university hospitals. Out of the 200 subjects, 129 had intermittent claudication and 71 had critical limb ischemia. Mean age was 70 +/- 9 y and 57% of the participants were male. All patients completed SF-36 and VascuQoL at the vascular outpatient clinic, when... (More)
Background: Traditional outcome measures in peripheral arterial disease (PAD) provide insufficient information regarding patient benefit. It has therefore been suggested to add patient-reported outcome measures. The main aim of this study was to validate the Swedish Vascular Quality of Life questionnaire (VascuQoL) version, a patient-reported PAD-specific health-related quality of life (HRQoL) instrument. Methods: Two-hundred PAD patients were consecutively recruited from two university hospitals. Out of the 200 subjects, 129 had intermittent claudication and 71 had critical limb ischemia. Mean age was 70 +/- 9 y and 57% of the participants were male. All patients completed SF-36 and VascuQoL at the vascular outpatient clinic, when evaluated for invasive treatment. Risk factors and physiological parameters were registered. Construct validity was tested by correlation analysis versus SF-36 and was also assessed with multitrait/multi-item scaling analysis (MTMI). Sensitivity analysis regarding disease severity identification was performed. Reliability was assessed with Cronbach's alpha and responsiveness by standardized response mean (SRM) calculations. Results: Significant correlations were demonstrated between relevant subscales of VascuQoL and SF-36. MTMI showed acceptable construct validity, but some scaling-errors. VascuQoL significantly (p < 0.001) discriminated claudicants from critical limb ischemia patients. Cronbach's alpha was 0.94 and SRM 1.02 (sum score). Conclusions: The Swedish version of VascuQoL is valid and quantifies central aspects of HRQoL in PAD patients. Sensitivity analysis showed high ability to differentiate between disease severity and SRM illustrated excellent responsiveness. The relative abundance of items however makes use in the everyday clinical setting somewhat difficult. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Patient-reported outcome measures, Health-related quality of life, Peripheral arterial disease, Intermittent claudication, Psychometric, validation
in
Health and Quality of Life Outcomes
volume
10
publisher
BioMed Central (BMC)
external identifiers
  • wos:000307516700001
  • scopus:84862189756
  • pmid:22545952
ISSN
1477-7525
DOI
10.1186/1477-7525-10-45
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Physiotherapy (Closed 2012) (013042000), Department of Health Sciences (013220000)
id
2f192564-c175-4401-b224-80834862402e (old id 3070026)
date added to LUP
2016-04-01 14:51:17
date last changed
2022-04-06 20:51:33
@article{2f192564-c175-4401-b224-80834862402e,
  abstract     = {{Background: Traditional outcome measures in peripheral arterial disease (PAD) provide insufficient information regarding patient benefit. It has therefore been suggested to add patient-reported outcome measures. The main aim of this study was to validate the Swedish Vascular Quality of Life questionnaire (VascuQoL) version, a patient-reported PAD-specific health-related quality of life (HRQoL) instrument. Methods: Two-hundred PAD patients were consecutively recruited from two university hospitals. Out of the 200 subjects, 129 had intermittent claudication and 71 had critical limb ischemia. Mean age was 70 +/- 9 y and 57% of the participants were male. All patients completed SF-36 and VascuQoL at the vascular outpatient clinic, when evaluated for invasive treatment. Risk factors and physiological parameters were registered. Construct validity was tested by correlation analysis versus SF-36 and was also assessed with multitrait/multi-item scaling analysis (MTMI). Sensitivity analysis regarding disease severity identification was performed. Reliability was assessed with Cronbach's alpha and responsiveness by standardized response mean (SRM) calculations. Results: Significant correlations were demonstrated between relevant subscales of VascuQoL and SF-36. MTMI showed acceptable construct validity, but some scaling-errors. VascuQoL significantly (p &lt; 0.001) discriminated claudicants from critical limb ischemia patients. Cronbach's alpha was 0.94 and SRM 1.02 (sum score). Conclusions: The Swedish version of VascuQoL is valid and quantifies central aspects of HRQoL in PAD patients. Sensitivity analysis showed high ability to differentiate between disease severity and SRM illustrated excellent responsiveness. The relative abundance of items however makes use in the everyday clinical setting somewhat difficult.}},
  author       = {{Nordanstig, Joakim and Karlsson, Jan and Pettersson, Monica and Wann-Hansson, Christine}},
  issn         = {{1477-7525}},
  keywords     = {{Patient-reported outcome measures; Health-related quality of life; Peripheral arterial disease; Intermittent claudication; Psychometric; validation}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Health and Quality of Life Outcomes}},
  title        = {{Psychometric properties of the disease-specific health-related quality of life instrument VascuQoL in a Swedish setting}},
  url          = {{https://lup.lub.lu.se/search/files/4199440/3567468.pdf}},
  doi          = {{10.1186/1477-7525-10-45}},
  volume       = {{10}},
  year         = {{2012}},
}