Synthesis of 2-substituted pyridines via a regiospecific alkylation, alkynylation, and arylation of pyridine N-oxides
(2007) In Organic Letters 9(7). p.1335-1337- Abstract
Figure presented Sequential addition of Grignard reagents to pyridine N-oxides in THF at room temperature followed by treatment with acetic anhydride at 120°C afforded 2-substituted pyridines in good to high yields. Furthermore, by exchanging acetic anhydride for DMF in the second step, 2-substituted pyridine N-oxides were obtained, as intermediates suitable for addition of a second Grignard reagent for the synthesis of 2,6-disubstituted pyridines.
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https://lup.lub.lu.se/record/3076406d-76ee-4cf3-be4d-daeadf537161
- author
- Andersson, Hans ; Almqvist, Fredrik and Olsson, Roger LU
- publishing date
- 2007-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Organic Letters
- volume
- 9
- issue
- 7
- pages
- 1335 - 1337
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:17328555
- scopus:34147178870
- ISSN
- 1523-7060
- DOI
- 10.1021/ol070184n
- language
- English
- LU publication?
- no
- id
- 3076406d-76ee-4cf3-be4d-daeadf537161
- date added to LUP
- 2019-10-02 11:00:21
- date last changed
- 2024-09-18 11:39:22
@article{3076406d-76ee-4cf3-be4d-daeadf537161, abstract = {{<p>Figure presented Sequential addition of Grignard reagents to pyridine N-oxides in THF at room temperature followed by treatment with acetic anhydride at 120°C afforded 2-substituted pyridines in good to high yields. Furthermore, by exchanging acetic anhydride for DMF in the second step, 2-substituted pyridine N-oxides were obtained, as intermediates suitable for addition of a second Grignard reagent for the synthesis of 2,6-disubstituted pyridines.</p>}}, author = {{Andersson, Hans and Almqvist, Fredrik and Olsson, Roger}}, issn = {{1523-7060}}, language = {{eng}}, month = {{03}}, number = {{7}}, pages = {{1335--1337}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Organic Letters}}, title = {{Synthesis of 2-substituted pyridines via a regiospecific alkylation, alkynylation, and arylation of pyridine N-oxides}}, url = {{http://dx.doi.org/10.1021/ol070184n}}, doi = {{10.1021/ol070184n}}, volume = {{9}}, year = {{2007}}, }