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Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer

Hardell, L; van Bavel, B; Lindstrom, G; Carlberg, M; Dreifaldt, AC; Wijkstrom, H; Starkhammar, H; Eriksson, Mikael LU ; Hallquist, A and Kolmert, T (2003) In Environmental Health Perspectives 111(7). p.930-934
Abstract
An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. According to current hypothesis, testicular cancer is initiated during the fetal period, and exposure to endocrine disruptors, i.e., xenoestrogens, has been of concern. In this investigation we studied the concentrations of the sum of 38 polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene, hexachlorobenzene (HCB), and chlordanes, in 61 cases with testicular cancer and 58 age-matched controls. Furthermore, case and control mothers were also asked to participate, and 44 case mothers and 45 control mothers agreed. They were of similar age. In cases only the concentration on lipid basis of... (More)
An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. According to current hypothesis, testicular cancer is initiated during the fetal period, and exposure to endocrine disruptors, i.e., xenoestrogens, has been of concern. In this investigation we studied the concentrations of the sum of 38 polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene, hexachlorobenzene (HCB), and chlordanes, in 61 cases with testicular cancer and 58 age-matched controls. Furthermore, case and control mothers were also asked to participate, and 44 case mothers and 45 control mothers agreed. They were of similar age. In cases only the concentration on lipid basis of cis-nonachlordane was significantly increased, whereas case mothers showed significantly increased concentrations of the sum of PCBs, HCB, trans- and cis-nonachlordane, and the sum of chlordanes. Among case mothers the sum of PCBs yielded an odds ratio (OR) of 3.8; 95% confidence interval (CI), 1.4-10 was calculated using the median concentration for the control mothers as cutoff value. For HCB, OR = 4.4 (95% CI, 1.7-12); for trans-nonachlordane, OR = 4.1 (95% CI, 1.5-11); for cis-nonachlordane, OR = 3.1 (95% CI, 1.2-7.8); and for sum of chlordanes, OR = 1.9 (95% CI, 0.7-5.0). No consistent different risk pattern was found for seminoma. or nonseminoma testicular cancer. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
testicular cancer, pollutants, persistent organic, hexachlorobenzene, chlordanes, fetal period, polychlorinated biphenyls
in
Environmental Health Perspectives
volume
111
issue
7
pages
930 - 934
publisher
National Institute of Environmental Health Science
external identifiers
  • wos:000183498900031
  • pmid:12782494
  • scopus:0038759618
ISSN
1552-9924
DOI
10.1289/ehp.5816
language
English
LU publication?
yes
id
79f65e94-bf64-4762-af0c-83a2f379c5da (old id 308572)
alternative location
http://www.ehponline.org/docs/2003/5816/abstract.html
date added to LUP
2007-09-13 07:24:40
date last changed
2018-10-03 10:30:01
@article{79f65e94-bf64-4762-af0c-83a2f379c5da,
  abstract     = {An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. According to current hypothesis, testicular cancer is initiated during the fetal period, and exposure to endocrine disruptors, i.e., xenoestrogens, has been of concern. In this investigation we studied the concentrations of the sum of 38 polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene, hexachlorobenzene (HCB), and chlordanes, in 61 cases with testicular cancer and 58 age-matched controls. Furthermore, case and control mothers were also asked to participate, and 44 case mothers and 45 control mothers agreed. They were of similar age. In cases only the concentration on lipid basis of cis-nonachlordane was significantly increased, whereas case mothers showed significantly increased concentrations of the sum of PCBs, HCB, trans- and cis-nonachlordane, and the sum of chlordanes. Among case mothers the sum of PCBs yielded an odds ratio (OR) of 3.8; 95% confidence interval (CI), 1.4-10 was calculated using the median concentration for the control mothers as cutoff value. For HCB, OR = 4.4 (95% CI, 1.7-12); for trans-nonachlordane, OR = 4.1 (95% CI, 1.5-11); for cis-nonachlordane, OR = 3.1 (95% CI, 1.2-7.8); and for sum of chlordanes, OR = 1.9 (95% CI, 0.7-5.0). No consistent different risk pattern was found for seminoma. or nonseminoma testicular cancer.},
  author       = {Hardell, L and van Bavel, B and Lindstrom, G and Carlberg, M and Dreifaldt, AC and Wijkstrom, H and Starkhammar, H and Eriksson, Mikael and Hallquist, A and Kolmert, T},
  issn         = {1552-9924},
  keyword      = {testicular cancer,pollutants,persistent organic,hexachlorobenzene,chlordanes,fetal period,polychlorinated biphenyls},
  language     = {eng},
  number       = {7},
  pages        = {930--934},
  publisher    = {National Institute of Environmental Health Science},
  series       = {Environmental Health Perspectives},
  title        = {Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer},
  url          = {http://dx.doi.org/10.1289/ehp.5816},
  volume       = {111},
  year         = {2003},
}