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Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau

Norrgren, Hans LU ; Da Silva, Z; Biague, A; Andersson, S and Biberfeld, G (2003) In Scandinavian Journal of Infectious Diseases 35(4). p.265-272
Abstract
The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was... (More)
The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was 8.6/100 person-years (py) ( rate ratio 6.2 compared with HIV-negative controls, 95% confidence interval 2.7 - 14.2, p< 0.001), and the progression rate to stage 4, i.e. acquired immunodeficiency syndrome ( AIDS), was 2.1/100 py. HIV-2-positive people in stage 3 at inclusion progressed to AIDS at a rate of 16.9/100 py. CD4% &LE; 20 was found to be a significant prognostic marker for progression to stage 4, both from stage 1 + 2 and from stage 3. The clinical progression in this cohort of HIV-2-infected subjects was generally lower than that in HIV-1-positive cohorts. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
35
issue
4
pages
265 - 272
publisher
Informa Healthcare
external identifiers
  • pmid:12839157
  • wos:000183000300012
  • scopus:0038760843
ISSN
1651-1980
DOI
language
English
LU publication?
yes
id
73b948a3-0254-40a5-b35b-a38666c5d9db (old id 309971)
date added to LUP
2007-09-19 14:33:27
date last changed
2018-05-29 09:35:58
@article{73b948a3-0254-40a5-b35b-a38666c5d9db,
  abstract     = {The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was 8.6/100 person-years (py) ( rate ratio 6.2 compared with HIV-negative controls, 95% confidence interval 2.7 - 14.2, p&lt; 0.001), and the progression rate to stage 4, i.e. acquired immunodeficiency syndrome ( AIDS), was 2.1/100 py. HIV-2-positive people in stage 3 at inclusion progressed to AIDS at a rate of 16.9/100 py. CD4% &amp;LE; 20 was found to be a significant prognostic marker for progression to stage 4, both from stage 1 + 2 and from stage 3. The clinical progression in this cohort of HIV-2-infected subjects was generally lower than that in HIV-1-positive cohorts.},
  author       = {Norrgren, Hans and Da Silva, Z and Biague, A and Andersson, S and Biberfeld, G},
  issn         = {1651-1980},
  language     = {eng},
  number       = {4},
  pages        = {265--272},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau},
  url          = {http://dx.doi.org/},
  volume       = {35},
  year         = {2003},
}