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Osteopontin : A Key Multifaceted Regulator in Tumor Progression and Immunomodulation

Panda, Venketesh K. ; Mishra, Barnalee ; Nath, Angitha N. ; Butti, Ramesh ; Yadav, Amit Singh LU ; Malhotra, Diksha ; Khanra, Sinjan ; Mahapatra, Samikshya ; Mishra, Priyanka and Swain, Biswajit , et al. (2024) In Biomedicines 12(7).
Abstract

The tumor microenvironment (TME) is composed of various cellular components such as tumor cells, stromal cells including fibroblasts, adipocytes, mast cells, lymphatic vascular cells and infiltrating immune cells, macrophages, dendritic cells and lymphocytes. The intricate interplay between these cells influences tumor growth, metastasis and therapy failure. Significant advancements in breast cancer therapy have resulted in a substantial decrease in mortality. However, existing cancer treatments frequently result in toxicity and nonspecific side effects. Therefore, improving targeted drug delivery and increasing the efficacy of drugs is crucial for enhancing treatment outcome and reducing the burden of toxicity. In this review, we have... (More)

The tumor microenvironment (TME) is composed of various cellular components such as tumor cells, stromal cells including fibroblasts, adipocytes, mast cells, lymphatic vascular cells and infiltrating immune cells, macrophages, dendritic cells and lymphocytes. The intricate interplay between these cells influences tumor growth, metastasis and therapy failure. Significant advancements in breast cancer therapy have resulted in a substantial decrease in mortality. However, existing cancer treatments frequently result in toxicity and nonspecific side effects. Therefore, improving targeted drug delivery and increasing the efficacy of drugs is crucial for enhancing treatment outcome and reducing the burden of toxicity. In this review, we have provided an overview of how tumor and stroma-derived osteopontin (OPN) plays a key role in regulating the oncogenic potential of various cancers including breast. Next, we dissected the signaling network by which OPN regulates tumor progression through interaction with selective integrins and CD44 receptors. This review addresses the latest advancements in the roles of splice variants of OPN in cancer progression and OPN-mediated tumor-stromal interaction, EMT, CSC enhancement, immunomodulation, metastasis, chemoresistance and metabolic reprogramming, and further suggests that OPN might be a potential therapeutic target and prognostic biomarker for the evolving landscape of cancer management.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer, cancer-associated fibroblasts, immunomodulation, osteopontin (OPN), single cell transcriptomics, targeted therapy, tumor-associated macrophages
in
Biomedicines
volume
12
issue
7
article number
1527
publisher
MDPI AG
external identifiers
  • scopus:85199762502
  • pmid:39062100
ISSN
2227-9059
DOI
10.3390/biomedicines12071527
language
English
LU publication?
yes
id
30ef951d-e112-40ee-993d-c960aa5d2af4
date added to LUP
2024-09-30 10:41:30
date last changed
2025-07-09 01:24:45
@article{30ef951d-e112-40ee-993d-c960aa5d2af4,
  abstract     = {{<p>The tumor microenvironment (TME) is composed of various cellular components such as tumor cells, stromal cells including fibroblasts, adipocytes, mast cells, lymphatic vascular cells and infiltrating immune cells, macrophages, dendritic cells and lymphocytes. The intricate interplay between these cells influences tumor growth, metastasis and therapy failure. Significant advancements in breast cancer therapy have resulted in a substantial decrease in mortality. However, existing cancer treatments frequently result in toxicity and nonspecific side effects. Therefore, improving targeted drug delivery and increasing the efficacy of drugs is crucial for enhancing treatment outcome and reducing the burden of toxicity. In this review, we have provided an overview of how tumor and stroma-derived osteopontin (OPN) plays a key role in regulating the oncogenic potential of various cancers including breast. Next, we dissected the signaling network by which OPN regulates tumor progression through interaction with selective integrins and CD44 receptors. This review addresses the latest advancements in the roles of splice variants of OPN in cancer progression and OPN-mediated tumor-stromal interaction, EMT, CSC enhancement, immunomodulation, metastasis, chemoresistance and metabolic reprogramming, and further suggests that OPN might be a potential therapeutic target and prognostic biomarker for the evolving landscape of cancer management.</p>}},
  author       = {{Panda, Venketesh K. and Mishra, Barnalee and Nath, Angitha N. and Butti, Ramesh and Yadav, Amit Singh and Malhotra, Diksha and Khanra, Sinjan and Mahapatra, Samikshya and Mishra, Priyanka and Swain, Biswajit and Majhi, Sambhunath and Kumari, Kavita and Radharani, N. N.V. and Kundu, Gopal C.}},
  issn         = {{2227-9059}},
  keywords     = {{cancer; cancer-associated fibroblasts; immunomodulation; osteopontin (OPN); single cell transcriptomics; targeted therapy; tumor-associated macrophages}},
  language     = {{eng}},
  number       = {{7}},
  publisher    = {{MDPI AG}},
  series       = {{Biomedicines}},
  title        = {{Osteopontin : A Key Multifaceted Regulator in Tumor Progression and Immunomodulation}},
  url          = {{http://dx.doi.org/10.3390/biomedicines12071527}},
  doi          = {{10.3390/biomedicines12071527}},
  volume       = {{12}},
  year         = {{2024}},
}