Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes.
(2009) In Diabetologia 52. p.1426-1433- Abstract
- AIMS/HYPOTHESIS: Oxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes. METHODS: We studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of... (More)
- AIMS/HYPOTHESIS: Oxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes. METHODS: We studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of coronary disease was assessed as the coronary artery calcium score. RESULTS: Patients affected by retinopathy had significantly higher levels of IgG against MDA-p45 and MDA-p210. In contrast, high levels of autoantibodies against the corresponding native peptides were associated with less coronary calcification and a lower risk of progression of coronary disease. CONCLUSIONS/INTERPRETATION: Our observations suggest that LDL oxidation is involved in the pathogenesis of diabetic retinopathy and that autoantibodies against apolipoprotein B peptides may act as biomarkers for both micro- and macrovascular complications in diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1412193
- author
- Nordin Fredrikson, Gunilla LU ; Anand, D ; Hopkins, D ; Corder, R ; Alm, Ragnar LU ; Bengtsson, Eva LU ; Shah, P ; Lahiri, A and Nilsson, Jan LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetologia
- volume
- 52
- pages
- 1426 - 1433
- publisher
- Springer
- external identifiers
-
- wos:000266496000027
- pmid:19448981
- scopus:67349151367
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-009-1377-9
- language
- English
- LU publication?
- yes
- id
- 31056c7a-4cbc-4876-b8a0-908cea6d772c (old id 1412193)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19448981?dopt=Abstract
- date added to LUP
- 2016-04-01 12:10:17
- date last changed
- 2022-01-26 23:47:32
@article{31056c7a-4cbc-4876-b8a0-908cea6d772c, abstract = {{AIMS/HYPOTHESIS: Oxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes. METHODS: We studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of coronary disease was assessed as the coronary artery calcium score. RESULTS: Patients affected by retinopathy had significantly higher levels of IgG against MDA-p45 and MDA-p210. In contrast, high levels of autoantibodies against the corresponding native peptides were associated with less coronary calcification and a lower risk of progression of coronary disease. CONCLUSIONS/INTERPRETATION: Our observations suggest that LDL oxidation is involved in the pathogenesis of diabetic retinopathy and that autoantibodies against apolipoprotein B peptides may act as biomarkers for both micro- and macrovascular complications in diabetes.}}, author = {{Nordin Fredrikson, Gunilla and Anand, D and Hopkins, D and Corder, R and Alm, Ragnar and Bengtsson, Eva and Shah, P and Lahiri, A and Nilsson, Jan}}, issn = {{1432-0428}}, language = {{eng}}, pages = {{1426--1433}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes.}}, url = {{https://lup.lub.lu.se/search/files/2811262/1458633.pdf}}, doi = {{10.1007/s00125-009-1377-9}}, volume = {{52}}, year = {{2009}}, }