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A link between Helicobacter pylori and/or Chlamydia spp. infections and atherosclerosis

Chmiela, Magdalena; Kowlewicz-Kulbat, Magdalena; Miszczak, Aneta; Wisniewska, Monika; Rechcinski, Tomasz; Kolodziej, Katarzyna; Kasprzak, Jaroslaw; Wadström, Torkel LU and Rudnicka, Wieslawa (2003) In Pathogens and Disease 36(3). p.187-192
Abstract
Antibodies to Helicobacter pylori, Chlamydia spp. and Mycobacterium bovis were determined in patients with coronary heart disease, H. pylori-related dyspepsia, and tuberculosis, and healthy controls. Enzyme-linked immunosorbent assay was conducted with a glycine extract and CagA protein of H. pylori, chlamydial lipopolysaccharide and mycobacterial heat shock protein Hsp65. The prevalence of anti-glycine extract IgG in coronary heart disease patients was higher than in the tuberculosis group and controls, and the same as in dyspeptic patients. Anti-chlamydial IgG were more prevalent in the coronary heart disease group than in healthy subjects. There was no difference in the prevalence of anti-CagA IgG in the coronary heart disease group and... (More)
Antibodies to Helicobacter pylori, Chlamydia spp. and Mycobacterium bovis were determined in patients with coronary heart disease, H. pylori-related dyspepsia, and tuberculosis, and healthy controls. Enzyme-linked immunosorbent assay was conducted with a glycine extract and CagA protein of H. pylori, chlamydial lipopolysaccharide and mycobacterial heat shock protein Hsp65. The prevalence of anti-glycine extract IgG in coronary heart disease patients was higher than in the tuberculosis group and controls, and the same as in dyspeptic patients. Anti-chlamydial IgG were more prevalent in the coronary heart disease group than in healthy subjects. There was no difference in the prevalence of anti-CagA IgG in the coronary heart disease group and controls or anti-Hsp65 IgG in the patients with coronary heart disease, dyspepsia, tuberculosis, and controls. Anti-glycine extract IgA (like anti-glycine extract IgG) were more prevalent in the coronary heart disease group than in the healthy group. The highest anti-glycine extract IgG/IgA and anti-chlamydial IgG titers were more frequent in coronary heart disease patients as compared with controls. Infections with H. pylori and Chlamydia spp. and enhanced production of antibodies to these pathogens may predispose to human atherosclerosis. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Helicobacter pylori, Chlamydia spp., atherosclerosis
in
Pathogens and Disease
volume
36
issue
3
pages
187 - 192
publisher
Wiley-Blackwell
external identifiers
  • wos:000182940400012
  • pmid:12738390
  • scopus:0038399975
ISSN
2049-632X
DOI
10.1016/S0928-8244(03)00030-0
language
English
LU publication?
yes
id
99056e6e-a2dc-4c1e-b976-048f047cf682 (old id 310909)
date added to LUP
2007-08-02 13:43:34
date last changed
2018-01-07 05:37:06
@article{99056e6e-a2dc-4c1e-b976-048f047cf682,
  abstract     = {Antibodies to Helicobacter pylori, Chlamydia spp. and Mycobacterium bovis were determined in patients with coronary heart disease, H. pylori-related dyspepsia, and tuberculosis, and healthy controls. Enzyme-linked immunosorbent assay was conducted with a glycine extract and CagA protein of H. pylori, chlamydial lipopolysaccharide and mycobacterial heat shock protein Hsp65. The prevalence of anti-glycine extract IgG in coronary heart disease patients was higher than in the tuberculosis group and controls, and the same as in dyspeptic patients. Anti-chlamydial IgG were more prevalent in the coronary heart disease group than in healthy subjects. There was no difference in the prevalence of anti-CagA IgG in the coronary heart disease group and controls or anti-Hsp65 IgG in the patients with coronary heart disease, dyspepsia, tuberculosis, and controls. Anti-glycine extract IgA (like anti-glycine extract IgG) were more prevalent in the coronary heart disease group than in the healthy group. The highest anti-glycine extract IgG/IgA and anti-chlamydial IgG titers were more frequent in coronary heart disease patients as compared with controls. Infections with H. pylori and Chlamydia spp. and enhanced production of antibodies to these pathogens may predispose to human atherosclerosis. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.},
  author       = {Chmiela, Magdalena and Kowlewicz-Kulbat, Magdalena and Miszczak, Aneta and Wisniewska, Monika and Rechcinski, Tomasz and Kolodziej, Katarzyna and Kasprzak, Jaroslaw and Wadström, Torkel and Rudnicka, Wieslawa},
  issn         = {2049-632X},
  keyword      = {Helicobacter pylori,Chlamydia spp.,atherosclerosis},
  language     = {eng},
  number       = {3},
  pages        = {187--192},
  publisher    = {Wiley-Blackwell},
  series       = {Pathogens and Disease},
  title        = {A link between Helicobacter pylori and/or Chlamydia spp. infections and atherosclerosis},
  url          = {http://dx.doi.org/10.1016/S0928-8244(03)00030-0},
  volume       = {36},
  year         = {2003},
}