Main targets of tetraaza macrocyclic copper complex on L1210 murine leukemia cells
(2002) In Toxicology in Vitro 16(5). p.491-498- Abstract
- Several metal complex agents have already been introduced into clinical tumor therapy and others are subject of antitumor studies. In this study we focused on the tetraaza macrocyclic copper complex (Cu(TAAB)Cl-2). We studied the influence of the substance on cell growth, cell cycle, membrane integrity, necrosis, apotosis and glutathione level on the leukemic cell line L1210 in 1-day (22 h) and 3-day (72 h) experiments. The metal complex shows a dose-dependent antiproliferative effect, without affecting cell cycle phases. The present results confirm that copper complex can damage plasmatic membranes and trigger apoptosis, and that after treatment of leukemic cells with the copper complex, glutathione levels were increased. (C) 2002... (More)
- Several metal complex agents have already been introduced into clinical tumor therapy and others are subject of antitumor studies. In this study we focused on the tetraaza macrocyclic copper complex (Cu(TAAB)Cl-2). We studied the influence of the substance on cell growth, cell cycle, membrane integrity, necrosis, apotosis and glutathione level on the leukemic cell line L1210 in 1-day (22 h) and 3-day (72 h) experiments. The metal complex shows a dose-dependent antiproliferative effect, without affecting cell cycle phases. The present results confirm that copper complex can damage plasmatic membranes and trigger apoptosis, and that after treatment of leukemic cells with the copper complex, glutathione levels were increased. (C) 2002 Elsevier Science Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/325835
- author
- Dovinova, Ima LU ; Paulikova, H ; Rauko, P ; Hunakova, L' ; Hanusovska, E and Tibenska, E
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- glutathione, stress, oxidative, apoptosis, membrane integrity, copper complex, cytotoxicity
- in
- Toxicology in Vitro
- volume
- 16
- issue
- 5
- pages
- 491 - 498
- publisher
- Elsevier
- external identifiers
-
- pmid:12206815
- wos:000178436200002
- scopus:0036801574
- ISSN
- 1879-3177
- DOI
- 10.1016/S0887-2333(02)00043-7
- language
- English
- LU publication?
- yes
- id
- 31135caa-49b6-4847-820f-ef1caa40c0fe (old id 325835)
- date added to LUP
- 2016-04-01 16:14:42
- date last changed
- 2022-02-27 19:52:47
@article{31135caa-49b6-4847-820f-ef1caa40c0fe,
abstract = {{Several metal complex agents have already been introduced into clinical tumor therapy and others are subject of antitumor studies. In this study we focused on the tetraaza macrocyclic copper complex (Cu(TAAB)Cl-2). We studied the influence of the substance on cell growth, cell cycle, membrane integrity, necrosis, apotosis and glutathione level on the leukemic cell line L1210 in 1-day (22 h) and 3-day (72 h) experiments. The metal complex shows a dose-dependent antiproliferative effect, without affecting cell cycle phases. The present results confirm that copper complex can damage plasmatic membranes and trigger apoptosis, and that after treatment of leukemic cells with the copper complex, glutathione levels were increased. (C) 2002 Elsevier Science Ltd. All rights reserved.}},
author = {{Dovinova, Ima and Paulikova, H and Rauko, P and Hunakova, L' and Hanusovska, E and Tibenska, E}},
issn = {{1879-3177}},
keywords = {{glutathione; stress; oxidative; apoptosis; membrane integrity; copper complex; cytotoxicity}},
language = {{eng}},
number = {{5}},
pages = {{491--498}},
publisher = {{Elsevier}},
series = {{Toxicology in Vitro}},
title = {{Main targets of tetraaza macrocyclic copper complex on L1210 murine leukemia cells}},
url = {{http://dx.doi.org/10.1016/S0887-2333(02)00043-7}},
doi = {{10.1016/S0887-2333(02)00043-7}},
volume = {{16}},
year = {{2002}},
}