Wound infiltration with ropivacaine and fentanyl: Effects on postoperative pain and PONV after breast surgery
(2003) In Journal of Clinical Anesthesia 15(2). p.113-118- Abstract
- Study Objective: To determine whether Postoperative wound infiltration with local anesthetics combined with fentanyl improves analgesia following breast surgery; and to investigate awakening and Postoperative nausea/vomiting. Design: Prospectively randomized clinical study. Setting: University hospital. Patients: 45 ASA physical status I and II patients scheduled for breast surgery. Interventions: Patients were prospectively randomized and assigned to one of three treatments during general anesthesia: postsurgical wound infiltration with ropivacaine 0.375%; wound infiltration with ropivacaine 0.375% combined with fentanyl 0.5 mug/kg; and intravenous (IV) fentanyl 0.5 mug/kg before skin incision and no wound infiltration. Time to first... (More)
- Study Objective: To determine whether Postoperative wound infiltration with local anesthetics combined with fentanyl improves analgesia following breast surgery; and to investigate awakening and Postoperative nausea/vomiting. Design: Prospectively randomized clinical study. Setting: University hospital. Patients: 45 ASA physical status I and II patients scheduled for breast surgery. Interventions: Patients were prospectively randomized and assigned to one of three treatments during general anesthesia: postsurgical wound infiltration with ropivacaine 0.375%; wound infiltration with ropivacaine 0.375% combined with fentanyl 0.5 mug/kg; and intravenous (IV) fentanyl 0.5 mug/kg before skin incision and no wound infiltration. Time to first verbal response, Pain at rest, Postoperative nausea and vomiting, and ketobemidone and dixyrazine utilization were compared. Measurements and Main Results: Time to first verbal response was significantly shorter in the IV fentanyl group compared to both infiltration groups (8.1 +/- 4.5 min vs. 15.3 +/- 4.3, and 12.0 +/- 5.0 min; p < 0.05, respectively). Postoperative Pain at rest, and nausea and vomiting occurred with similar frequencies in the groups. Ketobemidone utilization in both infiltration groups, (2.4 +/- 1.8 mg and 3.1 +/- 1.8 mg, respectively) was not different compared to the IV fentanyl group (2.9 +/- 2.0 mg; NS). There were no differences in Postoperative antiemetic requirements during the first, second and third two-hour periods postoperatively. The dixyrazine consumption was similar in the three groups, (0.9 +/- 1.5 mg, 0.8 +/- 1.3 mg, and 1.4 +/- 1.8 mg, respectively; NS). Conclusion: Postsurgical ropivacaine wound infiltration, with or without adding fentanyl, demonstrates no differences in postoperative Pain relief and nausea/vomiting compared to a balanced general anesthetic including IV fentanyl. (C) 2003 by Elsevier Science Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/312035
- author
- Johansson, Anders LU ; Kornfalt, J ; Nordin, L ; Svensson, L ; Ingvar, Christian LU and Lundberg, Johan LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- local anesthetics, anesthetic technique, wound infiltration
- in
- Journal of Clinical Anesthesia
- volume
- 15
- issue
- 2
- pages
- 113 - 118
- publisher
- Elsevier
- external identifiers
-
- pmid:12719050
- wos:000182714900006
- scopus:0037359972
- ISSN
- 1873-4529
- DOI
- 10.1016/S0952-8180(02)00511-1
- language
- English
- LU publication?
- yes
- id
- c3ed95b3-f48f-4003-8ef5-303f453b38ba (old id 312035)
- date added to LUP
- 2016-04-01 12:20:56
- date last changed
- 2022-01-27 02:29:25
@article{c3ed95b3-f48f-4003-8ef5-303f453b38ba, abstract = {{Study Objective: To determine whether Postoperative wound infiltration with local anesthetics combined with fentanyl improves analgesia following breast surgery; and to investigate awakening and Postoperative nausea/vomiting. Design: Prospectively randomized clinical study. Setting: University hospital. Patients: 45 ASA physical status I and II patients scheduled for breast surgery. Interventions: Patients were prospectively randomized and assigned to one of three treatments during general anesthesia: postsurgical wound infiltration with ropivacaine 0.375%; wound infiltration with ropivacaine 0.375% combined with fentanyl 0.5 mug/kg; and intravenous (IV) fentanyl 0.5 mug/kg before skin incision and no wound infiltration. Time to first verbal response, Pain at rest, Postoperative nausea and vomiting, and ketobemidone and dixyrazine utilization were compared. Measurements and Main Results: Time to first verbal response was significantly shorter in the IV fentanyl group compared to both infiltration groups (8.1 +/- 4.5 min vs. 15.3 +/- 4.3, and 12.0 +/- 5.0 min; p < 0.05, respectively). Postoperative Pain at rest, and nausea and vomiting occurred with similar frequencies in the groups. Ketobemidone utilization in both infiltration groups, (2.4 +/- 1.8 mg and 3.1 +/- 1.8 mg, respectively) was not different compared to the IV fentanyl group (2.9 +/- 2.0 mg; NS). There were no differences in Postoperative antiemetic requirements during the first, second and third two-hour periods postoperatively. The dixyrazine consumption was similar in the three groups, (0.9 +/- 1.5 mg, 0.8 +/- 1.3 mg, and 1.4 +/- 1.8 mg, respectively; NS). Conclusion: Postsurgical ropivacaine wound infiltration, with or without adding fentanyl, demonstrates no differences in postoperative Pain relief and nausea/vomiting compared to a balanced general anesthetic including IV fentanyl. (C) 2003 by Elsevier Science Inc.}}, author = {{Johansson, Anders and Kornfalt, J and Nordin, L and Svensson, L and Ingvar, Christian and Lundberg, Johan}}, issn = {{1873-4529}}, keywords = {{local anesthetics; anesthetic technique; wound infiltration}}, language = {{eng}}, number = {{2}}, pages = {{113--118}}, publisher = {{Elsevier}}, series = {{Journal of Clinical Anesthesia}}, title = {{Wound infiltration with ropivacaine and fentanyl: Effects on postoperative pain and PONV after breast surgery}}, url = {{http://dx.doi.org/10.1016/S0952-8180(02)00511-1}}, doi = {{10.1016/S0952-8180(02)00511-1}}, volume = {{15}}, year = {{2003}}, }