Effects of common polymorphisms in the alpha(1A)-, alpha(2B)-, beta(1)- and beta(2)-adrenoreceptors on haemodynamic responses to adrenaline
(2003) In Clinical Science 104(5). p.509-520- Abstract
- Common naturally occurring polymorphisms have been identified in the coding regions of the alpha(1A)-, alpha(2B)-, beta(1)- and beta(2)-adrenoceptor (AR) genes [alpha(1A)-AR R492C, alpha(2B)-AR insertion/deletion (I/D), beta(1)-AR R389G, beta(2)-AR G16R and beta(2)-AR Q27E] and are associated with modified in vivo and in vitro functionality. We tested their possible effects on the haemodynamic responses to intravenous adrenaline (20, 40, 80 and 160 ng/kg of body weight per min; 5 min for each infusion rate) before and after beta-blockade (propranolol) in 16 young healthy men. We monitored changes in heart rate, blood pressure (BP), ECG, coronary flow velocity and plasma adrenaline and noradrenaline. The Cys/Cys (CC) genotype of the... (More)
- Common naturally occurring polymorphisms have been identified in the coding regions of the alpha(1A)-, alpha(2B)-, beta(1)- and beta(2)-adrenoceptor (AR) genes [alpha(1A)-AR R492C, alpha(2B)-AR insertion/deletion (I/D), beta(1)-AR R389G, beta(2)-AR G16R and beta(2)-AR Q27E] and are associated with modified in vivo and in vitro functionality. We tested their possible effects on the haemodynamic responses to intravenous adrenaline (20, 40, 80 and 160 ng/kg of body weight per min; 5 min for each infusion rate) before and after beta-blockade (propranolol) in 16 young healthy men. We monitored changes in heart rate, blood pressure (BP), ECG, coronary flow velocity and plasma adrenaline and noradrenaline. The Cys/Cys (CC) genotype of the alpha(1A)-AR R492C polymorphism was associated with a longer ECG PR interval before and during the adrenaline infusions. The deletion/deletion (D/D) genotype of the alpha(2B)-AR I/D polymorphism was associated with blunted coronary blood flow increases during the adrenaline infusion before beta-blockade. The beta(1)-AR R389G polymorphism was not associated with modified responses to infused adrenaline. Subjects carrying the Gly/Gly (GG) genotype of the beta(2)-AR G16R polymorphism demonstrated increases in diastolic BP upon adrenaline infusion, whereas diastolic BP was decreased in the other genotype groups. These results suggest that, upon acute adrenaline infusion, the alpha(2B)-AR D/D genotype confers increased vasoconstriction and that the beta(2)-AR GG genotype confers reduced vasodilatation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/312153
- author
- Snapir, A ; Koskenvuo, J ; Toikka, J ; Orho-Melander, Marju LU ; Hinkka, S ; Saraste, M ; Hartiala, J and Scheinin, M
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- genetics, adrenaline, adrenoreceptors, in vivo, polymorphism
- in
- Clinical Science
- volume
- 104
- issue
- 5
- pages
- 509 - 520
- publisher
- Portland Press
- external identifiers
-
- wos:000182738000007
- pmid:12519093
- scopus:0038017249
- pmid:12519093
- ISSN
- 1470-8736
- DOI
- 10.1042/CS20020299
- language
- English
- LU publication?
- yes
- id
- 6257ce00-bee7-4cb7-8288-5a2f355152e3 (old id 312153)
- date added to LUP
- 2016-04-01 11:55:19
- date last changed
- 2024-04-08 18:23:08
@article{6257ce00-bee7-4cb7-8288-5a2f355152e3,
abstract = {{Common naturally occurring polymorphisms have been identified in the coding regions of the alpha(1A)-, alpha(2B)-, beta(1)- and beta(2)-adrenoceptor (AR) genes [alpha(1A)-AR R492C, alpha(2B)-AR insertion/deletion (I/D), beta(1)-AR R389G, beta(2)-AR G16R and beta(2)-AR Q27E] and are associated with modified in vivo and in vitro functionality. We tested their possible effects on the haemodynamic responses to intravenous adrenaline (20, 40, 80 and 160 ng/kg of body weight per min; 5 min for each infusion rate) before and after beta-blockade (propranolol) in 16 young healthy men. We monitored changes in heart rate, blood pressure (BP), ECG, coronary flow velocity and plasma adrenaline and noradrenaline. The Cys/Cys (CC) genotype of the alpha(1A)-AR R492C polymorphism was associated with a longer ECG PR interval before and during the adrenaline infusions. The deletion/deletion (D/D) genotype of the alpha(2B)-AR I/D polymorphism was associated with blunted coronary blood flow increases during the adrenaline infusion before beta-blockade. The beta(1)-AR R389G polymorphism was not associated with modified responses to infused adrenaline. Subjects carrying the Gly/Gly (GG) genotype of the beta(2)-AR G16R polymorphism demonstrated increases in diastolic BP upon adrenaline infusion, whereas diastolic BP was decreased in the other genotype groups. These results suggest that, upon acute adrenaline infusion, the alpha(2B)-AR D/D genotype confers increased vasoconstriction and that the beta(2)-AR GG genotype confers reduced vasodilatation.}},
author = {{Snapir, A and Koskenvuo, J and Toikka, J and Orho-Melander, Marju and Hinkka, S and Saraste, M and Hartiala, J and Scheinin, M}},
issn = {{1470-8736}},
keywords = {{genetics; adrenaline; adrenoreceptors; in vivo; polymorphism}},
language = {{eng}},
number = {{5}},
pages = {{509--520}},
publisher = {{Portland Press}},
series = {{Clinical Science}},
title = {{Effects of common polymorphisms in the alpha(1A)-, alpha(2B)-, beta(1)- and beta(2)-adrenoreceptors on haemodynamic responses to adrenaline}},
url = {{http://dx.doi.org/10.1042/CS20020299}},
doi = {{10.1042/CS20020299}},
volume = {{104}},
year = {{2003}},
}