Advanced

Bradykinin receptor subtype 1 expression and function in prostate cancer

Taub, JS; Guo, R; Leeb-Lundberg, Fredrik LU ; Madden, JF and Daaka, Y (2003) In Cancer Research 63(9). p.2037-2041
Abstract
Kinins exert multiple pathophysiological functions, including vascular permeability and mitogenesis, by activating their cognate receptors, bradykinin subtype 1 receptor (B1R) and bradykinin subtype 2 receptor (B2R), which belong to the superfamily of G protein-coupled receptors. Tissue-specific expression pattern or contribution of the individual kinin receptors to pathological prostate cell growth is not known. We report here the differential expression of B1R and B2R in human benign and malignant prostate specimens. Whereas B2R is ubiquitously expressed, the B1R is detected only in prostatic intraepithelial neoplasia and malignant lesions and not in benign prostate tissues. Using androgen-insensitive prostate cancer PC3 cells, we show... (More)
Kinins exert multiple pathophysiological functions, including vascular permeability and mitogenesis, by activating their cognate receptors, bradykinin subtype 1 receptor (B1R) and bradykinin subtype 2 receptor (B2R), which belong to the superfamily of G protein-coupled receptors. Tissue-specific expression pattern or contribution of the individual kinin receptors to pathological prostate cell growth is not known. We report here the differential expression of B1R and B2R in human benign and malignant prostate specimens. Whereas B2R is ubiquitously expressed, the B1R is detected only in prostatic intraepithelial neoplasia and malignant lesions and not in benign prostate tissues. Using androgen-insensitive prostate cancer PC3 cells, we show that specific stimulation of endogenous B1R promotes cell growth, migration, and invasion. These findings identify B1R as an early marker for pathological growth of the prostate and suggest its potential utility as a drug target effective for the treatment of prostate cancer. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Research
volume
63
issue
9
pages
2037 - 2041
publisher
American Association for Cancer Research Inc.
external identifiers
  • wos:000182640400009
  • pmid:12727816
  • scopus:0037729000
ISSN
1538-7445
language
English
LU publication?
yes
id
ec5adfc1-f16c-4eab-8f7d-e2339f4c9486 (old id 312199)
alternative location
http://cancerres.aacrjournals.org/cgi/content/abstract/63/9/2037
date added to LUP
2007-09-23 10:25:35
date last changed
2018-10-03 11:11:26
@article{ec5adfc1-f16c-4eab-8f7d-e2339f4c9486,
  abstract     = {Kinins exert multiple pathophysiological functions, including vascular permeability and mitogenesis, by activating their cognate receptors, bradykinin subtype 1 receptor (B1R) and bradykinin subtype 2 receptor (B2R), which belong to the superfamily of G protein-coupled receptors. Tissue-specific expression pattern or contribution of the individual kinin receptors to pathological prostate cell growth is not known. We report here the differential expression of B1R and B2R in human benign and malignant prostate specimens. Whereas B2R is ubiquitously expressed, the B1R is detected only in prostatic intraepithelial neoplasia and malignant lesions and not in benign prostate tissues. Using androgen-insensitive prostate cancer PC3 cells, we show that specific stimulation of endogenous B1R promotes cell growth, migration, and invasion. These findings identify B1R as an early marker for pathological growth of the prostate and suggest its potential utility as a drug target effective for the treatment of prostate cancer.},
  author       = {Taub, JS and Guo, R and Leeb-Lundberg, Fredrik and Madden, JF and Daaka, Y},
  issn         = {1538-7445},
  language     = {eng},
  number       = {9},
  pages        = {2037--2041},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Bradykinin receptor subtype 1 expression and function in prostate cancer},
  volume       = {63},
  year         = {2003},
}