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Peptides that regulate food intake - Separable mechanisms for dorsal hindbrain CART peptide to inhibit gastric emptying and food intake

Smedh, Ulrika LU and Moran, TH (2003) In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 284(6). p.1418-1426
Abstract
We investigated whether dorsal hindbrain and/or peripheral cocaine- and amphetamine-regulated transcript peptide (CARTp) acts to suppress gastric emptying of a caloric stimulus. Furthermore, effects of dorsal hindbrain CARTp on sucrose consumption and licking microstructure was studied, as well as the possible contribution of corticotropin-releasing factor (CRF) receptors to mediate effects of CARTp downstream on emptying and sucrose intake. Rats bearing gastric fistulas received intragastric infusions (1.0 ml/min) of 12 ml 12.5% glucose. Gastric samples were withdrawn immediately after the intragastric infusion to reflect emptying during gastric fill. CARTp injected in the fourth ventricle intracerebroventricularly (0.5 and 1.0 mug)... (More)
We investigated whether dorsal hindbrain and/or peripheral cocaine- and amphetamine-regulated transcript peptide (CARTp) acts to suppress gastric emptying of a caloric stimulus. Furthermore, effects of dorsal hindbrain CARTp on sucrose consumption and licking microstructure was studied, as well as the possible contribution of corticotropin-releasing factor (CRF) receptors to mediate effects of CARTp downstream on emptying and sucrose intake. Rats bearing gastric fistulas received intragastric infusions (1.0 ml/min) of 12 ml 12.5% glucose. Gastric samples were withdrawn immediately after the intragastric infusion to reflect emptying during gastric fill. CARTp injected in the fourth ventricle intracerebroventricularly (0.5 and 1.0 mug) suppressed gastric emptying. CARTp reduced sucrose intake at similar doses and altered a variety of lick microstructure variables ( no. of licks, bursts, clusters, licks/burst, licks/clusters, interlick interval, first meal size, and first meal duration). Pretreatment with the CRF antagonist alpha-helical CRF-(9- 41) blocked the effect of 1.0 mug CARTp on gastric emptying but not on sucrose consumed or on any of the licking microstructure parameters. These data demonstrate differential mediation of the feeding and gastric inhibitory effects of CARTp and suggest that CARTp-induced inhibition of gastric emptying does not contribute to this peptide's ability to inhibit food intake. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
corticotropin-releasing factor, brain stem, licking, ingestive behavior, microstructure
in
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
volume
284
issue
6
pages
1418 - 1426
publisher
American Physiological Society
external identifiers
  • pmid:12468444
  • wos:000182700000012
ISSN
0363-6119
DOI
language
English
LU publication?
yes
id
b6cb0573-4d34-4dd0-934b-056935877126 (old id 312339)
date added to LUP
2007-09-22 10:52:31
date last changed
2018-05-29 10:11:52
@article{b6cb0573-4d34-4dd0-934b-056935877126,
  abstract     = {We investigated whether dorsal hindbrain and/or peripheral cocaine- and amphetamine-regulated transcript peptide (CARTp) acts to suppress gastric emptying of a caloric stimulus. Furthermore, effects of dorsal hindbrain CARTp on sucrose consumption and licking microstructure was studied, as well as the possible contribution of corticotropin-releasing factor (CRF) receptors to mediate effects of CARTp downstream on emptying and sucrose intake. Rats bearing gastric fistulas received intragastric infusions (1.0 ml/min) of 12 ml 12.5% glucose. Gastric samples were withdrawn immediately after the intragastric infusion to reflect emptying during gastric fill. CARTp injected in the fourth ventricle intracerebroventricularly (0.5 and 1.0 mug) suppressed gastric emptying. CARTp reduced sucrose intake at similar doses and altered a variety of lick microstructure variables ( no. of licks, bursts, clusters, licks/burst, licks/clusters, interlick interval, first meal size, and first meal duration). Pretreatment with the CRF antagonist alpha-helical CRF-(9- 41) blocked the effect of 1.0 mug CARTp on gastric emptying but not on sucrose consumed or on any of the licking microstructure parameters. These data demonstrate differential mediation of the feeding and gastric inhibitory effects of CARTp and suggest that CARTp-induced inhibition of gastric emptying does not contribute to this peptide's ability to inhibit food intake.},
  author       = {Smedh, Ulrika and Moran, TH},
  issn         = {0363-6119},
  keyword      = {corticotropin-releasing factor,brain stem,licking,ingestive behavior,microstructure},
  language     = {eng},
  number       = {6},
  pages        = {1418--1426},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Regulatory, Integrative and Comparative Physiology},
  title        = {Peptides that regulate food intake - Separable mechanisms for dorsal hindbrain CART peptide to inhibit gastric emptying and food intake},
  url          = {http://dx.doi.org/},
  volume       = {284},
  year         = {2003},
}