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Elevated Plasma Homocysteine Level Is Not Primarily Related to Alzheimer's Disease.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2012) In Dementia and Geriatric Cognitive Disorders 34(2). p.121-127
Abstract
Background: A moderate elevation of plasma total homocysteine (tHcy) is considered a potential risk factor for Alzheimer's disease (AD). Methods: We have investigated the main determinants (age, renal impairment, cobalamin/folate status and the presence of vascular disease) of plasma tHcy in 326 patients with AD, and also in 281 patients with mild cognitive impairment (MCI), since about half of these patients develop AD during the first 5 years. Results: Elevated plasma tHcy in patients with AD could mainly be attributed to cobalamin/folate deficiency or renal impairment. Younger patients (below 75 years) with AD and patients with MCI without cobalamin/folate deficiency or renal impairment showed normal levels of plasma tHcy. Conclusion:... (More)
Background: A moderate elevation of plasma total homocysteine (tHcy) is considered a potential risk factor for Alzheimer's disease (AD). Methods: We have investigated the main determinants (age, renal impairment, cobalamin/folate status and the presence of vascular disease) of plasma tHcy in 326 patients with AD, and also in 281 patients with mild cognitive impairment (MCI), since about half of these patients develop AD during the first 5 years. Results: Elevated plasma tHcy in patients with AD could mainly be attributed to cobalamin/folate deficiency or renal impairment. Younger patients (below 75 years) with AD and patients with MCI without cobalamin/folate deficiency or renal impairment showed normal levels of plasma tHcy. Conclusion: Our findings suggest that plasma tHcy is not primarily involved in the pathogenesis of AD but rather a reflection of changes of the main determinants of plasma tHcy in AD patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
34
issue
2
pages
121 - 127
publisher
Karger
external identifiers
  • wos:000310997000007
  • pmid:23006895
  • scopus:84866482141
ISSN
1420-8008
DOI
10.1159/000342612
language
English
LU publication?
yes
id
abb2bb71-12db-4c53-ac72-26cbd2751a93 (old id 3123676)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23006895?dopt=Abstract
date added to LUP
2012-10-04 13:50:50
date last changed
2017-09-10 04:45:37
@article{abb2bb71-12db-4c53-ac72-26cbd2751a93,
  abstract     = {Background: A moderate elevation of plasma total homocysteine (tHcy) is considered a potential risk factor for Alzheimer's disease (AD). Methods: We have investigated the main determinants (age, renal impairment, cobalamin/folate status and the presence of vascular disease) of plasma tHcy in 326 patients with AD, and also in 281 patients with mild cognitive impairment (MCI), since about half of these patients develop AD during the first 5 years. Results: Elevated plasma tHcy in patients with AD could mainly be attributed to cobalamin/folate deficiency or renal impairment. Younger patients (below 75 years) with AD and patients with MCI without cobalamin/folate deficiency or renal impairment showed normal levels of plasma tHcy. Conclusion: Our findings suggest that plasma tHcy is not primarily involved in the pathogenesis of AD but rather a reflection of changes of the main determinants of plasma tHcy in AD patients.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1420-8008},
  language     = {eng},
  number       = {2},
  pages        = {121--127},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Elevated Plasma Homocysteine Level Is Not Primarily Related to Alzheimer's Disease.},
  url          = {http://dx.doi.org/10.1159/000342612},
  volume       = {34},
  year         = {2012},
}