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The Expression of β-Microseminoprotein but Not CRISP3 Is Reduced in Ovarian Cancer and Correlates to Survival.

Henriksen, Rudi LU ; Lundwall, Åke LU ; Udby, Lene and Fernlund, Per LU (2012) In Anticancer Research 32(9). p.3993-3999
Abstract
β-Microseminoprotein (MSMB) is an abundant protein in seminal plasma. Most of it is present as a free protein but a small part is bound to cysteine-rich secretory protein 3 (CRISP3) as a non-covalent complex. Even though their physiological function is unknown, both MSMB and CRISP3 have been ascribed roles in prostate carcinogenesis. Thus, several recent experimental studies indicate a tumor-suppressor role for MSMB. The present study was undertaken in order to evaluate, for the first time, the expression of MSMB and CRISP3 in ovaries and in ovarian tumors and to determine if their expression might indicate a role in ovarian tumor development.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CRISP3, beta-Microseminoprotein, immunohistochemistry, ovary, ovarian, cancer, survival
in
Anticancer Research
volume
32
issue
9
pages
3993 - 3999
publisher
International Institute of Cancer Research
external identifiers
  • wos:000309243200053
  • pmid:22993349
  • scopus:84866990034
ISSN
1791-7530
language
English
LU publication?
yes
id
9a9597f1-ab7f-4dd4-b296-132009c1b73a (old id 3123838)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22993349?dopt=Abstract
date added to LUP
2012-10-03 22:19:18
date last changed
2017-01-01 03:53:32
@article{9a9597f1-ab7f-4dd4-b296-132009c1b73a,
  abstract     = {β-Microseminoprotein (MSMB) is an abundant protein in seminal plasma. Most of it is present as a free protein but a small part is bound to cysteine-rich secretory protein 3 (CRISP3) as a non-covalent complex. Even though their physiological function is unknown, both MSMB and CRISP3 have been ascribed roles in prostate carcinogenesis. Thus, several recent experimental studies indicate a tumor-suppressor role for MSMB. The present study was undertaken in order to evaluate, for the first time, the expression of MSMB and CRISP3 in ovaries and in ovarian tumors and to determine if their expression might indicate a role in ovarian tumor development.},
  author       = {Henriksen, Rudi and Lundwall, Åke and Udby, Lene and Fernlund, Per},
  issn         = {1791-7530},
  keyword      = {CRISP3,beta-Microseminoprotein,immunohistochemistry,ovary,ovarian,cancer,survival},
  language     = {eng},
  number       = {9},
  pages        = {3993--3999},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {The Expression of β-Microseminoprotein but Not CRISP3 Is Reduced in Ovarian Cancer and Correlates to Survival.},
  volume       = {32},
  year         = {2012},
}