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A biokinetic study of (209)Po in man.

Henricsson, Fredrik LU ; Ranebo, Ylva LU ; Hansson, Mats LU ; Rääf, Christopher LU and Holm, Elis (2012) In Science of the Total Environment 437C. p.384-389
Abstract
Five adult volunteers participated in a biokinetic study of radioactive polonium. Portions of about 10Bq of (209)Po were orally administrated to four of the volunteers in a single ingestion. The fifth volunteer ingested a daily amount of 53mBq of 209Po for 243d to study the time to achieve equilibrium between intake and excretion for protracted intakes. For the subjects ingesting single intakes of (209)Po complete sampling of urine and feces was subsequently collected the first few days upon the ingestion. The samples were processed with radiochemical extraction and analyzed with alpha spectrometry. In the study, the maximum daily excretion rates in feces were 18-50% of the ingested activity, observed within 3d after intake. Regarding the... (More)
Five adult volunteers participated in a biokinetic study of radioactive polonium. Portions of about 10Bq of (209)Po were orally administrated to four of the volunteers in a single ingestion. The fifth volunteer ingested a daily amount of 53mBq of 209Po for 243d to study the time to achieve equilibrium between intake and excretion for protracted intakes. For the subjects ingesting single intakes of (209)Po complete sampling of urine and feces was subsequently collected the first few days upon the ingestion. The samples were processed with radiochemical extraction and analyzed with alpha spectrometry. In the study, the maximum daily excretion rates in feces were 18-50% of the ingested activity, observed within 3d after intake. Regarding the urine excretion, the daily excretion peaked, on average, at 0.15-1% of the ingested activity within two days upon intake. These results indicate an average gastro-intestinal uptake fraction of 0.46±0.08, which agrees well with earlier biokinetic studies of polonium in man. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biokinetics, Polonium, Po-209, Biological half-time, Metabolism, Uptake, fraction
in
Science of the Total Environment
volume
437C
pages
384 - 389
publisher
Elsevier
external identifiers
  • wos:000310941000044
  • pmid:22960113
  • scopus:84865657713
ISSN
1879-1026
DOI
10.1016/j.scitotenv.2012.07.080
language
English
LU publication?
yes
id
842da5ea-d42c-4d8b-bf1d-42aa9bc62767 (old id 3124113)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22960113?dopt=Abstract
date added to LUP
2012-10-04 17:09:58
date last changed
2017-02-26 03:15:57
@article{842da5ea-d42c-4d8b-bf1d-42aa9bc62767,
  abstract     = {Five adult volunteers participated in a biokinetic study of radioactive polonium. Portions of about 10Bq of (209)Po were orally administrated to four of the volunteers in a single ingestion. The fifth volunteer ingested a daily amount of 53mBq of 209Po for 243d to study the time to achieve equilibrium between intake and excretion for protracted intakes. For the subjects ingesting single intakes of (209)Po complete sampling of urine and feces was subsequently collected the first few days upon the ingestion. The samples were processed with radiochemical extraction and analyzed with alpha spectrometry. In the study, the maximum daily excretion rates in feces were 18-50% of the ingested activity, observed within 3d after intake. Regarding the urine excretion, the daily excretion peaked, on average, at 0.15-1% of the ingested activity within two days upon intake. These results indicate an average gastro-intestinal uptake fraction of 0.46±0.08, which agrees well with earlier biokinetic studies of polonium in man.},
  author       = {Henricsson, Fredrik and Ranebo, Ylva and Hansson, Mats and Rääf, Christopher and Holm, Elis},
  issn         = {1879-1026},
  keyword      = {Biokinetics,Polonium,Po-209,Biological half-time,Metabolism,Uptake,fraction},
  language     = {eng},
  pages        = {384--389},
  publisher    = {Elsevier},
  series       = {Science of the Total Environment},
  title        = {A biokinetic study of (209)Po in man.},
  url          = {http://dx.doi.org/10.1016/j.scitotenv.2012.07.080},
  volume       = {437C},
  year         = {2012},
}