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Computational multiscale modeling of embryo development.

Krupinski, Pawel LU ; Chickarmane, Vijay and Peterson, Carsten LU (2012) In Current Opinion in Genetics & Development
Abstract
Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Genetics & Development
publisher
Elsevier
external identifiers
  • wos:000314490300014
  • pmid:22959149
  • scopus:84872662899
ISSN
1879-0380
DOI
10.1016/j.gde.2012.08.006
language
English
LU publication?
yes
id
76cd779c-fb7b-4510-a6db-fd5156f547e9 (old id 3124135)
date added to LUP
2012-10-12 21:08:20
date last changed
2017-08-13 04:01:40
@article{76cd779c-fb7b-4510-a6db-fd5156f547e9,
  abstract     = {Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.},
  author       = {Krupinski, Pawel and Chickarmane, Vijay and Peterson, Carsten},
  issn         = {1879-0380},
  language     = {eng},
  month        = {09},
  publisher    = {Elsevier},
  series       = {Current Opinion in Genetics & Development},
  title        = {Computational multiscale modeling of embryo development.},
  url          = {http://dx.doi.org/10.1016/j.gde.2012.08.006},
  year         = {2012},
}