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Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years

Taioli, E; Gaspari, L; Benhamou, S; Boffeta, P; Brockmoller, J; Butkiewicz, D; Cascorbi, I; Clapper, ML; Dolzan, V and Haugen, A, et al. (2003) In International Journal of Epidemiology 32(1). p.60-63
Abstract
Background A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. Methods The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and less than or equal to45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls. Results There was a marginally significant association between... (More)
Background A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. Methods The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and less than or equal to45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls. Results There was a marginally significant association between lung cancer and GST1 null genotype (OR = 1.2; 95% Cl: 1.0-1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A1*2A and *2B) genotype (OR = 4.7 95% Cl: 1.2-19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers. Conclusions These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages. (Less)
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International Journal of Epidemiology
volume
32
issue
1
pages
60 - 63
publisher
Oxford University Press
external identifiers
  • wos:000182341300012
  • pmid:12690010
  • scopus:0037320436
ISSN
1464-3685
DOI
10.1093/ije/dyg001
language
English
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yes
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04539d66-e868-426f-9dde-1741186b1a40 (old id 313041)
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http://ije.oxfordjournals.org/cgi/content/abstract/32/1/60
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2007-09-23 10:12:04
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2017-08-06 03:36:03
@article{04539d66-e868-426f-9dde-1741186b1a40,
  abstract     = {Background A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. Methods The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and less than or equal to45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls. Results There was a marginally significant association between lung cancer and GST1 null genotype (OR = 1.2; 95% Cl: 1.0-1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A1*2A and *2B) genotype (OR = 4.7 95% Cl: 1.2-19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers. Conclusions These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages.},
  author       = {Taioli, E and Gaspari, L and Benhamou, S and Boffeta, P and Brockmoller, J and Butkiewicz, D and Cascorbi, I and Clapper, ML and Dolzan, V and Haugen, A and Hirvonen, A and Husgafvel-Pursiainen, K and Kalina, I and Kremers, P and Le Marchand, L and London, S and Rannug, A and Romkes, M and Schoket, B and Seidegård, Janeric and Strange, RC and Stucker, I and To-Figueras, J and Garte, S},
  issn         = {1464-3685},
  language     = {eng},
  number       = {1},
  pages        = {60--63},
  publisher    = {Oxford University Press},
  series       = {International Journal of Epidemiology},
  title        = {Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years},
  url          = {http://dx.doi.org/10.1093/ije/dyg001},
  volume       = {32},
  year         = {2003},
}