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Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden

Gupta, Manu; Nikitina-Zake, Liene; Zarghami, Marjan; Landin-Olsson, Mona LU ; Kockum, Ingrid; Lernmark, Åke and Sanjeevi, Carani B (2003) In Human Immunology 64(5). p.553-561
Abstract
Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-35 years old. MIC-A5 was significantly increased in T1DM compared with controls (odds ratio [OR] =1.81, p(c) < 0.0005). Logistic regression analysis revealed MIC-A5 association was independent of HLA. MIC-A5 with DR4-DQ8 or MIC-A5 with DR3-DQ2 gave higher OR than the OR obtained with either of them alone (OR = 1.81, 7.1, and 3.6, respectively).... (More)
Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-35 years old. MIC-A5 was significantly increased in T1DM compared with controls (odds ratio [OR] =1.81, p(c) < 0.0005). Logistic regression analysis revealed MIC-A5 association was independent of HLA. MIC-A5 with DR4-DQ8 or MIC-A5 with DR3-DQ2 gave higher OR than the OR obtained with either of them alone (OR = 1.81, 7.1, and 3.6, respectively). MIC-A5 was positively (OR = 2.48, p(c) < 0.0005) and MIC-A6 negatively associated (OR = 0.61, p(c) = 0.035) with the disease in less than or equal to 20 years of age. The negative association of MIC-A6 in young onset was confirmed by logistic regression analysis. MIC-A5 was associated with the disease in males (OR = 2.05, p(c) = 0.0005). MIC-A6 conferred protection (OR = 0.098, p(c) = 0.032) in females heterozygous for DR3/DR4. In conclusion, MIC-A5 is associated with T1DM; the association was higher in individuals less than or equal to 20 years old; and negative association of MIC-A6 was stronger in younger onset patients than in older onset patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Swedish population, autoimmune disease, gender, HLA, age
in
Human Immunology
volume
64
issue
5
pages
553 - 561
publisher
Elsevier
external identifiers
  • wos:000182424500009
  • pmid:12691706
  • scopus:0037404664
ISSN
0198-8859
DOI
10.1016/S0198-8859(03)00035-1
language
English
LU publication?
yes
id
53f324f8-f049-454f-89c1-78fe5c1a0689 (old id 313066)
date added to LUP
2007-08-02 16:21:05
date last changed
2018-09-30 03:37:34
@article{53f324f8-f049-454f-89c1-78fe5c1a0689,
  abstract     = {Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-35 years old. MIC-A5 was significantly increased in T1DM compared with controls (odds ratio [OR] =1.81, p(c) &lt; 0.0005). Logistic regression analysis revealed MIC-A5 association was independent of HLA. MIC-A5 with DR4-DQ8 or MIC-A5 with DR3-DQ2 gave higher OR than the OR obtained with either of them alone (OR = 1.81, 7.1, and 3.6, respectively). MIC-A5 was positively (OR = 2.48, p(c) &lt; 0.0005) and MIC-A6 negatively associated (OR = 0.61, p(c) = 0.035) with the disease in less than or equal to 20 years of age. The negative association of MIC-A6 in young onset was confirmed by logistic regression analysis. MIC-A5 was associated with the disease in males (OR = 2.05, p(c) = 0.0005). MIC-A6 conferred protection (OR = 0.098, p(c) = 0.032) in females heterozygous for DR3/DR4. In conclusion, MIC-A5 is associated with T1DM; the association was higher in individuals less than or equal to 20 years old; and negative association of MIC-A6 was stronger in younger onset patients than in older onset patients.},
  author       = {Gupta, Manu and Nikitina-Zake, Liene and Zarghami, Marjan and Landin-Olsson, Mona and Kockum, Ingrid and Lernmark, Åke and Sanjeevi, Carani B},
  issn         = {0198-8859},
  keyword      = {Swedish population,autoimmune disease,gender,HLA,age},
  language     = {eng},
  number       = {5},
  pages        = {553--561},
  publisher    = {Elsevier},
  series       = {Human Immunology},
  title        = {Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden},
  url          = {http://dx.doi.org/10.1016/S0198-8859(03)00035-1},
  volume       = {64},
  year         = {2003},
}