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Polyamine dependence of normal cell-cycle progression

Oredsson, Stina LU (2003) In Biochemical Society Transactions 31. p.366-370
Abstract
The driving force of the cell cycle is the activities of cyclin-dependent kinases (CDKs). Key steps in the regulation of the cell cycle therefore must impinge upon the activities of the CDKs. CDKs exert their functions when bound to cyclins that are expressed cyclically during the cell cycle. Polyamine biosynthesis varies bicyclically during the cell cycle with peaks in enzyme activities at the G(1)/S and S/G(2) transitions. The enzyme activities are regulated at transcriptional, translational and post-translational levels. When cells are seeded in the presence of drugs that interfere with polyamine biosynthesis, cell cycle progression is affected within one cell cycle after seeding. The cell cycle phase that is most sensitive to polyamine... (More)
The driving force of the cell cycle is the activities of cyclin-dependent kinases (CDKs). Key steps in the regulation of the cell cycle therefore must impinge upon the activities of the CDKs. CDKs exert their functions when bound to cyclins that are expressed cyclically during the cell cycle. Polyamine biosynthesis varies bicyclically during the cell cycle with peaks in enzyme activities at the G(1)/S and S/G(2) transitions. The enzyme activities are regulated at transcriptional, translational and post-translational levels. When cells are seeded in the presence of drugs that interfere with polyamine biosynthesis, cell cycle progression is affected within one cell cycle after seeding. The cell cycle phase that is most sensitive to polyamine biosynthesis inhibition is the S phase, while effects on the G(1) and G(2)/M phases occur at later time points. The elongation step of DNA replication is negatively affected when polyamine pools are not allowed to increase normally during cell proliferation. Cyclin A is expressed during the S phase and cyclin A/CDK2 is important for a normal rate of DNA elongation. Cyclin A expression is lowered in cells treated with polyamine biosynthesis inhibitors. Thus, polyamines may affect S phase progression by participating in the regulation of cyclin A expression. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
decarboxylase, ornithine, cyclin, S-adenosylmethionine decarboxylase, cell cycle, polyamine
in
Biochemical Society Transactions
volume
31
pages
366 - 370
publisher
Biochemical Society
external identifiers
  • wos:000182338800016
  • pmid:12653640
  • scopus:0037398138
ISSN
0300-5127
language
English
LU publication?
yes
id
bee06827-fbd7-4631-81ae-9a1bd5ef3f14 (old id 313117)
alternative location
http://www.biochemsoctrans.org/bst/031/bst0310366.htm
date added to LUP
2007-09-20 07:46:30
date last changed
2018-10-03 11:12:03
@article{bee06827-fbd7-4631-81ae-9a1bd5ef3f14,
  abstract     = {The driving force of the cell cycle is the activities of cyclin-dependent kinases (CDKs). Key steps in the regulation of the cell cycle therefore must impinge upon the activities of the CDKs. CDKs exert their functions when bound to cyclins that are expressed cyclically during the cell cycle. Polyamine biosynthesis varies bicyclically during the cell cycle with peaks in enzyme activities at the G(1)/S and S/G(2) transitions. The enzyme activities are regulated at transcriptional, translational and post-translational levels. When cells are seeded in the presence of drugs that interfere with polyamine biosynthesis, cell cycle progression is affected within one cell cycle after seeding. The cell cycle phase that is most sensitive to polyamine biosynthesis inhibition is the S phase, while effects on the G(1) and G(2)/M phases occur at later time points. The elongation step of DNA replication is negatively affected when polyamine pools are not allowed to increase normally during cell proliferation. Cyclin A is expressed during the S phase and cyclin A/CDK2 is important for a normal rate of DNA elongation. Cyclin A expression is lowered in cells treated with polyamine biosynthesis inhibitors. Thus, polyamines may affect S phase progression by participating in the regulation of cyclin A expression.},
  author       = {Oredsson, Stina},
  issn         = {0300-5127},
  keyword      = {decarboxylase,ornithine,cyclin,S-adenosylmethionine decarboxylase,cell cycle,polyamine},
  language     = {eng},
  pages        = {366--370},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {Polyamine dependence of normal cell-cycle progression},
  volume       = {31},
  year         = {2003},
}