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Contribution of Different Limb Controllers to Modulation of Motor Cortex Neurons during Locomotion.

Zelenin, Pavel V; Deliagina, Tatiana G; Orlovsky, Grigori N; Nyström, Anastasia LU ; Dasgupta, Namrata M; Sirota, Mikhail G and Beloozerova, Irina N (2011) In Journal of Neuroscience 31(12). p.49-4636
Abstract
During locomotion, neurons in motor cortex exhibit profound step-related frequency modulation. The source of this modulation is unclear. The aim of this study was to reveal the contribution of different limb controllers (locomotor mechanisms of individual limbs) to the periodic modulation of motor cortex neurons during locomotion. Experiments were conducted in chronically instrumented cats. The activity of single neurons was recorded during regular quadrupedal locomotion (control), as well as when only one pair of limbs (fore, hind, right, or left) was walking while another pair was standing. Comparison of the modulation patterns in these neurons (their discharge profile with respect to the step cycle) during control and different bipedal... (More)
During locomotion, neurons in motor cortex exhibit profound step-related frequency modulation. The source of this modulation is unclear. The aim of this study was to reveal the contribution of different limb controllers (locomotor mechanisms of individual limbs) to the periodic modulation of motor cortex neurons during locomotion. Experiments were conducted in chronically instrumented cats. The activity of single neurons was recorded during regular quadrupedal locomotion (control), as well as when only one pair of limbs (fore, hind, right, or left) was walking while another pair was standing. Comparison of the modulation patterns in these neurons (their discharge profile with respect to the step cycle) during control and different bipedal locomotor tasks revealed several groups of neurons that receive distinct combinations of inputs from different limb controllers. In the majority (73%) of neurons from the forelimb area of motor cortex, modulation during control was determined exclusively by forelimb controllers (right, left, or both), while in the minority (27%), hindlimb controllers also contributed. By contrast, only in 30% of neurons from the hindlimb area was modulation determined exclusively by hindlimb controllers (right or both), while in 70% of them, the controllers of forelimbs also contributed. We suggest that such organization of inputs allows the motor cortex to contribute to the right-left limbs' coordination within each of the girdles during locomotion, and that it also allows hindlimb neurons to participate in coordination of the movements of the hindlimbs with those of the forelimbs. (Less)
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author
organization
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Contribution to journal
publication status
published
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in
Journal of Neuroscience
volume
31
issue
12
pages
49 - 4636
publisher
Society for Neuroscience
external identifiers
  • Scopus:79953013774
ISSN
1529-2401
language
English
LU publication?
yes
id
bb2a2bac-f1f0-47eb-bca8-b15c5a6dc70e (old id 3132129)
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date added to LUP
2012-11-07 14:39:29
date last changed
2017-01-15 04:28:39
@article{bb2a2bac-f1f0-47eb-bca8-b15c5a6dc70e,
  abstract     = {During locomotion, neurons in motor cortex exhibit profound step-related frequency modulation. The source of this modulation is unclear. The aim of this study was to reveal the contribution of different limb controllers (locomotor mechanisms of individual limbs) to the periodic modulation of motor cortex neurons during locomotion. Experiments were conducted in chronically instrumented cats. The activity of single neurons was recorded during regular quadrupedal locomotion (control), as well as when only one pair of limbs (fore, hind, right, or left) was walking while another pair was standing. Comparison of the modulation patterns in these neurons (their discharge profile with respect to the step cycle) during control and different bipedal locomotor tasks revealed several groups of neurons that receive distinct combinations of inputs from different limb controllers. In the majority (73%) of neurons from the forelimb area of motor cortex, modulation during control was determined exclusively by forelimb controllers (right, left, or both), while in the minority (27%), hindlimb controllers also contributed. By contrast, only in 30% of neurons from the hindlimb area was modulation determined exclusively by hindlimb controllers (right or both), while in 70% of them, the controllers of forelimbs also contributed. We suggest that such organization of inputs allows the motor cortex to contribute to the right-left limbs' coordination within each of the girdles during locomotion, and that it also allows hindlimb neurons to participate in coordination of the movements of the hindlimbs with those of the forelimbs.},
  author       = {Zelenin, Pavel V and Deliagina, Tatiana G and Orlovsky, Grigori N and Nyström, Anastasia and Dasgupta, Namrata M and Sirota, Mikhail G and Beloozerova, Irina N},
  issn         = {1529-2401},
  language     = {eng},
  number       = {12},
  pages        = {49--4636},
  publisher    = {Society for Neuroscience},
  series       = {Journal of Neuroscience},
  title        = {Contribution of Different Limb Controllers to Modulation of Motor Cortex Neurons during Locomotion.},
  volume       = {31},
  year         = {2011},
}