Advanced

Influences of sensory input from the limbs on feline corticospinal neurons during postural responses.

Nyström, Anastasia LU ; Deliagina, T G; Tamarova, Z A; Sirota, M G; Zelenin, P V; Orlovsky, G N and Beloozerova, I N (2008) In Journal of Physiology 586(1). p.63-247
Abstract
The dorsal-side-up body posture of standing quadrupeds is maintained by coordinated activity of all limbs. Somatosensory input from the limbs evokes postural responses when the supporting surface is perturbed. The aim of this study was to reveal the contribution of sensory inputs from individual limbs to the posture-related modulation of pyramidal tract neurons (PTNs) arising in the primary motor cortex. We recorded the activity of PTNs from the limb representation of motor cortex in the cat maintaining balance on a platform periodically tilted in the frontal plane. Each PTN was recorded during standing on four limbs, and when two or three limbs were lifted from the platform and thus did not signal its displacement to motor cortex. By... (More)
The dorsal-side-up body posture of standing quadrupeds is maintained by coordinated activity of all limbs. Somatosensory input from the limbs evokes postural responses when the supporting surface is perturbed. The aim of this study was to reveal the contribution of sensory inputs from individual limbs to the posture-related modulation of pyramidal tract neurons (PTNs) arising in the primary motor cortex. We recorded the activity of PTNs from the limb representation of motor cortex in the cat maintaining balance on a platform periodically tilted in the frontal plane. Each PTN was recorded during standing on four limbs, and when two or three limbs were lifted from the platform and thus did not signal its displacement to motor cortex. By comparing PTN responses to tilts in different tests we found that the amplitude and the phase of the response in the majority of them were determined primarily by the sensory input from the corresponding contralateral limb. In a portion of PTNs, this input originated from afferents of the peripheral receptive field. Sensory input from the ipsilateral limb, as well as input from limbs of the other girdle made a much smaller contribution to the PTN modulation. These results show that, during postural activity, a key role of PTNs is the feedback control of the corresponding contralateral limb and, to a lesser extent, the coordination of posture within a girdle and between the two girdles. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Motor Cortex, Male, Female, Feedback, Extremities, Somatosensory, Evoked Potentials, Animals, Cats, Neurons, Afferent, Posture, Pyramidal Tracts
in
Journal of Physiology
volume
586
issue
1
pages
63 - 247
publisher
The Physiological Society
external identifiers
  • scopus:37749028504
ISSN
1469-7793
language
English
LU publication?
no
id
acf59fb5-779b-43ae-b40f-1350223df6ec (old id 3132158)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17974591&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=17974591&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
date added to LUP
2012-11-07 14:33:11
date last changed
2017-03-12 04:21:38
@article{acf59fb5-779b-43ae-b40f-1350223df6ec,
  abstract     = {The dorsal-side-up body posture of standing quadrupeds is maintained by coordinated activity of all limbs. Somatosensory input from the limbs evokes postural responses when the supporting surface is perturbed. The aim of this study was to reveal the contribution of sensory inputs from individual limbs to the posture-related modulation of pyramidal tract neurons (PTNs) arising in the primary motor cortex. We recorded the activity of PTNs from the limb representation of motor cortex in the cat maintaining balance on a platform periodically tilted in the frontal plane. Each PTN was recorded during standing on four limbs, and when two or three limbs were lifted from the platform and thus did not signal its displacement to motor cortex. By comparing PTN responses to tilts in different tests we found that the amplitude and the phase of the response in the majority of them were determined primarily by the sensory input from the corresponding contralateral limb. In a portion of PTNs, this input originated from afferents of the peripheral receptive field. Sensory input from the ipsilateral limb, as well as input from limbs of the other girdle made a much smaller contribution to the PTN modulation. These results show that, during postural activity, a key role of PTNs is the feedback control of the corresponding contralateral limb and, to a lesser extent, the coordination of posture within a girdle and between the two girdles.},
  author       = {Nyström, Anastasia and Deliagina, T G and Tamarova, Z A and Sirota, M G and Zelenin, P V and Orlovsky, G N and Beloozerova, I N},
  issn         = {1469-7793},
  keyword      = {Motor Cortex,Male,Female,Feedback,Extremities,Somatosensory,Evoked Potentials,Animals,Cats,Neurons,Afferent,Posture,Pyramidal Tracts},
  language     = {eng},
  number       = {1},
  pages        = {63--247},
  publisher    = {The Physiological Society},
  series       = {Journal of Physiology},
  title        = {Influences of sensory input from the limbs on feline corticospinal neurons during postural responses.},
  volume       = {586},
  year         = {2008},
}