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The Role of octopamine and tyramine in Drosophila larval locomotion

Selcho, Mareike; Pauls, Dennis; el Jundi, Basil LU ; Stocker, Reinhard F. and Thum, Andreas S. (2012) In Journal of Comparative Neurology 520(16). p.3764-3785
Abstract
The characteristic crawling behavior of Drosophila larvae consists of a series of rhythmic waves of peristalsis and episodes of head swinging and turning. The two biogenic amines octopamine and tyramine have recently been shown to modulate various parameters of locomotion, such as muscle contraction, the time spent in pausing or forward locomotion, and the initiation and maintenance of rhythmic motor patterns. By using mutants having altered octopamine and tyramine levels and by genetic interference with both systems we confirm that signaling of these two amines is necessary for larval locomotion. We show that a small set of about 40 octopaminergic/tyraminergic neurons within the ventral nerve cord is sufficient to trigger proper larval... (More)
The characteristic crawling behavior of Drosophila larvae consists of a series of rhythmic waves of peristalsis and episodes of head swinging and turning. The two biogenic amines octopamine and tyramine have recently been shown to modulate various parameters of locomotion, such as muscle contraction, the time spent in pausing or forward locomotion, and the initiation and maintenance of rhythmic motor patterns. By using mutants having altered octopamine and tyramine levels and by genetic interference with both systems we confirm that signaling of these two amines is necessary for larval locomotion. We show that a small set of about 40 octopaminergic/tyraminergic neurons within the ventral nerve cord is sufficient to trigger proper larval locomotion. Using single-cell clones, we describe the morphology of these neurons individually. Given various potential roles of octopamine and tyramine in the larval brain, such as locomotion, learning and memory, stress-induced behaviors or the regulation of the energy state, functions that are often not easy to discriminate, we dissect here for the first time a subset of this complex circuit that modulates specifically larval locomotion. Thus, these data will help to understandfor a given neuronal modulatorhow specific behavioral functions are executed within distinct subcircuits of a complex neuronal network. J. Comp. Neurol. 520:37643785, 2012. (C) 2012 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Drosophila larva, locomotion, single cell analysis, octopamine, tyramine
in
Journal of Comparative Neurology
volume
520
issue
16
pages
3764 - 3785
publisher
John Wiley & Sons
external identifiers
  • wos:000308406400012
  • scopus:84865841012
ISSN
1096-9861
DOI
10.1002/cne.23152
language
English
LU publication?
yes
id
13c7fb42-9c95-4e96-8a4f-453acde9100c (old id 3132759)
date added to LUP
2012-11-01 16:40:15
date last changed
2017-10-01 03:16:16
@article{13c7fb42-9c95-4e96-8a4f-453acde9100c,
  abstract     = {The characteristic crawling behavior of Drosophila larvae consists of a series of rhythmic waves of peristalsis and episodes of head swinging and turning. The two biogenic amines octopamine and tyramine have recently been shown to modulate various parameters of locomotion, such as muscle contraction, the time spent in pausing or forward locomotion, and the initiation and maintenance of rhythmic motor patterns. By using mutants having altered octopamine and tyramine levels and by genetic interference with both systems we confirm that signaling of these two amines is necessary for larval locomotion. We show that a small set of about 40 octopaminergic/tyraminergic neurons within the ventral nerve cord is sufficient to trigger proper larval locomotion. Using single-cell clones, we describe the morphology of these neurons individually. Given various potential roles of octopamine and tyramine in the larval brain, such as locomotion, learning and memory, stress-induced behaviors or the regulation of the energy state, functions that are often not easy to discriminate, we dissect here for the first time a subset of this complex circuit that modulates specifically larval locomotion. Thus, these data will help to understandfor a given neuronal modulatorhow specific behavioral functions are executed within distinct subcircuits of a complex neuronal network. J. Comp. Neurol. 520:37643785, 2012. (C) 2012 Wiley Periodicals, Inc.},
  author       = {Selcho, Mareike and Pauls, Dennis and el Jundi, Basil and Stocker, Reinhard F. and Thum, Andreas S.},
  issn         = {1096-9861},
  keyword      = {Drosophila larva,locomotion,single cell analysis,octopamine,tyramine},
  language     = {eng},
  number       = {16},
  pages        = {3764--3785},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Comparative Neurology},
  title        = {The Role of octopamine and tyramine in Drosophila larval locomotion},
  url          = {http://dx.doi.org/10.1002/cne.23152},
  volume       = {520},
  year         = {2012},
}