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Clinical aspects of using exhaled NO in asthma diagnosis and management

Ludviksdottir, Dora; Diamant, Zuzana LU ; Alving, Kjell; Bjermer, Leif LU and Malinovschi, Andrei (2012) In Clinical Respiratory Journal 6(4). p.193-207
Abstract
Background Current guidelines recommend tailoring of asthma management according to disease control, which is largely defined by increased symptoms and deterioration in lung function. These features do not reflect the severity nor the type of the asthmatic airway inflammation. Fractional exhaled nitric oxide (FENO) is a simple, non-invasive and cost-effective online test applicable in both adults and children. In addition to symptoms and lung function measurements, FENO reflects airway eosinophilia and hence allows online assessment of the corticosteroid-sensitive T helper 2 type airway inflammation in asthmatic patients. FENO can thus be applied to aid asthma diagnosis and treatment monitoring both in clinical practice and for research... (More)
Background Current guidelines recommend tailoring of asthma management according to disease control, which is largely defined by increased symptoms and deterioration in lung function. These features do not reflect the severity nor the type of the asthmatic airway inflammation. Fractional exhaled nitric oxide (FENO) is a simple, non-invasive and cost-effective online test applicable in both adults and children. In addition to symptoms and lung function measurements, FENO reflects airway eosinophilia and hence allows online assessment of the corticosteroid-sensitive T helper 2 type airway inflammation in asthmatic patients. FENO can thus be applied to aid asthma diagnosis and treatment monitoring both in clinical practice and for research purposes. Objectives The scope of this review is to provide an overview of the most important clinical studies using FENO in asthma management and to summarise the implications of FENO measurements in clinical practice. Results and Conclusion In several studies, FENO measurements provided additional information on aspects of asthma including phenotyping, corticosteroid-responsiveness and disease control. Thus, if correctly applied and interpreted, FENO can aid asthma diagnosis, identify patients at risk of exacerbation and support customized treatment decisions. A simple and reliable tool to quantify peripheral nitric oxide will further aid to identify patients with small airways inflammation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
phenotypes, asthma management, asthma diagnosis, airway inflammation, asthma, exhaled nitric oxide
in
Clinical Respiratory Journal
volume
6
issue
4
pages
193 - 207
publisher
Wiley-Blackwell
external identifiers
  • wos:000308641100001
  • scopus:84866169834
ISSN
1752-6981
DOI
10.1111/crj.12001
language
English
LU publication?
yes
id
f2f2e5d5-f92c-4009-9e88-bf30cd4195f3 (old id 3132775)
date added to LUP
2012-11-01 16:37:14
date last changed
2017-09-10 03:18:19
@article{f2f2e5d5-f92c-4009-9e88-bf30cd4195f3,
  abstract     = {Background Current guidelines recommend tailoring of asthma management according to disease control, which is largely defined by increased symptoms and deterioration in lung function. These features do not reflect the severity nor the type of the asthmatic airway inflammation. Fractional exhaled nitric oxide (FENO) is a simple, non-invasive and cost-effective online test applicable in both adults and children. In addition to symptoms and lung function measurements, FENO reflects airway eosinophilia and hence allows online assessment of the corticosteroid-sensitive T helper 2 type airway inflammation in asthmatic patients. FENO can thus be applied to aid asthma diagnosis and treatment monitoring both in clinical practice and for research purposes. Objectives The scope of this review is to provide an overview of the most important clinical studies using FENO in asthma management and to summarise the implications of FENO measurements in clinical practice. Results and Conclusion In several studies, FENO measurements provided additional information on aspects of asthma including phenotyping, corticosteroid-responsiveness and disease control. Thus, if correctly applied and interpreted, FENO can aid asthma diagnosis, identify patients at risk of exacerbation and support customized treatment decisions. A simple and reliable tool to quantify peripheral nitric oxide will further aid to identify patients with small airways inflammation.},
  author       = {Ludviksdottir, Dora and Diamant, Zuzana and Alving, Kjell and Bjermer, Leif and Malinovschi, Andrei},
  issn         = {1752-6981},
  keyword      = {phenotypes,asthma management,asthma diagnosis,airway inflammation,asthma,exhaled nitric oxide},
  language     = {eng},
  number       = {4},
  pages        = {193--207},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Respiratory Journal},
  title        = {Clinical aspects of using exhaled NO in asthma diagnosis and management},
  url          = {http://dx.doi.org/10.1111/crj.12001},
  volume       = {6},
  year         = {2012},
}