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The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study

Haugen, Ida Kristin; Felson, David T.; Englund, Martin LU ; Wang, Ke; Aliabadi, Piran; Guermazi, Ali; Roemer, Frank W. and Neogi, Tuhina (2012) In Annals of the Rheumatic Diseases 71(10). p.1698-1701
Abstract
Objective To examine whether erosive hand osteoarthritis (OA) is associated with knee subchondral bone attrition (SBA) and systemic bone mineral density (BMD). Methods Associations of MRI-defined knee SBA with radiographic erosive hand OA were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the number of erosive OA finger joints and SBA adjusted for the number of non-erosive OA finger joints. Associations between erosive hand OA and femoral neck BMD were explored in 2236 participants with linear regression. Analyses were adjusted for age, sex and body mass index. Results Participants with erosive hand OA had increased odds of knee SBA (OR =... (More)
Objective To examine whether erosive hand osteoarthritis (OA) is associated with knee subchondral bone attrition (SBA) and systemic bone mineral density (BMD). Methods Associations of MRI-defined knee SBA with radiographic erosive hand OA were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the number of erosive OA finger joints and SBA adjusted for the number of non-erosive OA finger joints. Associations between erosive hand OA and femoral neck BMD were explored in 2236 participants with linear regression. Analyses were adjusted for age, sex and body mass index. Results Participants with erosive hand OA had increased odds of knee SBA (OR = 1.60, 95% CI 1.07 to 2.38). The relation between the number of erosive OA finger joints and SBA became non-significant when adjusted for the number of non-erosive OA joints as a proxy for the burden of disease. There was a non-significant trend towards higher BMD in erosive hand OA compared with participants without hand OA. Conclusions Erosive hand OA was associated with knee SBA, but the relation might be best explained by a heightened burden of disease. No significant relation of erosive hand OA with BMD was found. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
71
issue
10
pages
1698 - 1701
publisher
British Medical Association
external identifiers
  • wos:000308747900018
  • scopus:84866124365
ISSN
1468-2060
DOI
10.1136/annrheumdis-2012-201659
language
English
LU publication?
yes
id
9eb51dd3-26ea-4001-8989-986ce24ed300 (old id 3135896)
date added to LUP
2012-11-01 16:23:16
date last changed
2017-03-12 03:46:02
@article{9eb51dd3-26ea-4001-8989-986ce24ed300,
  abstract     = {Objective To examine whether erosive hand osteoarthritis (OA) is associated with knee subchondral bone attrition (SBA) and systemic bone mineral density (BMD). Methods Associations of MRI-defined knee SBA with radiographic erosive hand OA were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the number of erosive OA finger joints and SBA adjusted for the number of non-erosive OA finger joints. Associations between erosive hand OA and femoral neck BMD were explored in 2236 participants with linear regression. Analyses were adjusted for age, sex and body mass index. Results Participants with erosive hand OA had increased odds of knee SBA (OR = 1.60, 95% CI 1.07 to 2.38). The relation between the number of erosive OA finger joints and SBA became non-significant when adjusted for the number of non-erosive OA joints as a proxy for the burden of disease. There was a non-significant trend towards higher BMD in erosive hand OA compared with participants without hand OA. Conclusions Erosive hand OA was associated with knee SBA, but the relation might be best explained by a heightened burden of disease. No significant relation of erosive hand OA with BMD was found.},
  author       = {Haugen, Ida Kristin and Felson, David T. and Englund, Martin and Wang, Ke and Aliabadi, Piran and Guermazi, Ali and Roemer, Frank W. and Neogi, Tuhina},
  issn         = {1468-2060},
  language     = {eng},
  number       = {10},
  pages        = {1698--1701},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2012-201659},
  volume       = {71},
  year         = {2012},
}