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Concordance of Tumor Differentiation Among Brothers with Prostate Cancer

Jansson, K. Fredrik; Akre, Olof; Garmo, Hans; Bill-Axelson, Anna; Adolfsson, Jan; Stattin, Par and Bratt, Ola LU (2012) In European Urology 62(4). p.656-661
Abstract
Background: Genetic factors seem to be of greater importance in prostate cancer than in other forms of cancer. Studies have suggested familial concordance in survival, but the extent to which that is due to tumor characteristics is not known. Objective: We hypothesized that a brother of an index case with prostate cancer is at particularly increased risk of prostate cancer with the same tumor differentiation as the index case. Design, setting and participants: We identified 21 930 brothers of index cases with prostate cancer in the Prostate Cancer Data Base Sweden and followed them up for incidence of prostate cancer. Outcome measurements and statistical analysis: The relative risk of Gleason score-specific prostate cancer in the cohort of... (More)
Background: Genetic factors seem to be of greater importance in prostate cancer than in other forms of cancer. Studies have suggested familial concordance in survival, but the extent to which that is due to tumor characteristics is not known. Objective: We hypothesized that a brother of an index case with prostate cancer is at particularly increased risk of prostate cancer with the same tumor differentiation as the index case. Design, setting and participants: We identified 21 930 brothers of index cases with prostate cancer in the Prostate Cancer Data Base Sweden and followed them up for incidence of prostate cancer. Outcome measurements and statistical analysis: The relative risk of Gleason score-specific prostate cancer in the cohort of brothers was estimated by using the standardized incidence ratio (SIR) stratified by Gleason score of the index case. We estimated 95% confidence intervals (CIs) assuming a Poisson distribution. Results and limitations: Among brothers of index cases with Gleason score 8-10 cancer, the SIR was 2.53 (95% CI, 1.97-3.21) for a Gleason score 2-6 cancer and 4.00 (95% CI, 2.63-5.82) for a Gleason score 8-10 cancer. SIR for Gleason score 2-6 cancer among brothers decreased with time since the date of the index cases' diagnoses, whereas the risk of Gleason 8-10 cancer increased over time for brothers of index cases with Gleason 8-10 cancer (p for trend = 0.009). Conclusions: Brothers of men with high-grade prostate cancer are at particularly increased risk of high-grade prostate cancer. Likewise, there is a concordance of less malignant prostate cancers within families. These findings may have direct clinical relevance for counseling men with a family history of prostate cancer. (C) 2012 European Association of Urology. Published by Elsevier B. V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Familial prostate cancer, Gleason score, PCBaSe Sweden, Tumor, differentiation
in
European Urology
volume
62
issue
4
pages
656 - 661
publisher
Elsevier
external identifiers
  • wos:000308563100023
  • scopus:84865696634
ISSN
1873-7560
DOI
10.1016/j.eururo.2012.02.032
language
English
LU publication?
yes
id
834628c8-ff9c-4868-98d4-a3ebda3bb0fe (old id 3135923)
date added to LUP
2012-11-01 16:17:40
date last changed
2017-05-07 04:00:46
@article{834628c8-ff9c-4868-98d4-a3ebda3bb0fe,
  abstract     = {Background: Genetic factors seem to be of greater importance in prostate cancer than in other forms of cancer. Studies have suggested familial concordance in survival, but the extent to which that is due to tumor characteristics is not known. Objective: We hypothesized that a brother of an index case with prostate cancer is at particularly increased risk of prostate cancer with the same tumor differentiation as the index case. Design, setting and participants: We identified 21 930 brothers of index cases with prostate cancer in the Prostate Cancer Data Base Sweden and followed them up for incidence of prostate cancer. Outcome measurements and statistical analysis: The relative risk of Gleason score-specific prostate cancer in the cohort of brothers was estimated by using the standardized incidence ratio (SIR) stratified by Gleason score of the index case. We estimated 95% confidence intervals (CIs) assuming a Poisson distribution. Results and limitations: Among brothers of index cases with Gleason score 8-10 cancer, the SIR was 2.53 (95% CI, 1.97-3.21) for a Gleason score 2-6 cancer and 4.00 (95% CI, 2.63-5.82) for a Gleason score 8-10 cancer. SIR for Gleason score 2-6 cancer among brothers decreased with time since the date of the index cases' diagnoses, whereas the risk of Gleason 8-10 cancer increased over time for brothers of index cases with Gleason 8-10 cancer (p for trend = 0.009). Conclusions: Brothers of men with high-grade prostate cancer are at particularly increased risk of high-grade prostate cancer. Likewise, there is a concordance of less malignant prostate cancers within families. These findings may have direct clinical relevance for counseling men with a family history of prostate cancer. (C) 2012 European Association of Urology. Published by Elsevier B. V. All rights reserved.},
  author       = {Jansson, K. Fredrik and Akre, Olof and Garmo, Hans and Bill-Axelson, Anna and Adolfsson, Jan and Stattin, Par and Bratt, Ola},
  issn         = {1873-7560},
  keyword      = {Familial prostate cancer,Gleason score,PCBaSe Sweden,Tumor,differentiation},
  language     = {eng},
  number       = {4},
  pages        = {656--661},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Concordance of Tumor Differentiation Among Brothers with Prostate Cancer},
  url          = {http://dx.doi.org/10.1016/j.eururo.2012.02.032},
  volume       = {62},
  year         = {2012},
}