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Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma

Behrens, Thomas; Lynge, Elsebeth; Cree, Ian; Lutz, Jean-Michel; Eriksson, Mikael LU ; Guenel, Pascal; Merletti, Franco; Morales-Suarez-Varela, Maria; Afonso, Noemia and Stengrevics, Aivars, et al. (2012) In Scandinavian Journal of Work, Environment and Health 38(5). p.476-483
Abstract
Objectives We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case control study from nine European countries. Methods After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration.... (More)
Objectives We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case control study from nine European countries. Methods After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure. Results The overall exposure prevalence to EDC was low reaching a maximum of 11% for heavy metals with endocrine-disrupting properties. Although working in some industries was associated with increased melanoma risk [such as dry cleaning: odds ratio (OR) 6.15, 95% confidence interval (95% CI) 2.0-18.96 and working in the glass manufacturing industry: OR 3.49, 95% CI 1.10-11.10], agent-specific risks were not elevated. The strongest possible risk increase was observed for organic solvents with endocrine-disrupting properties (OR 1.31, 95% CI 0.78-2.21). Calculation of exposure scores did not indicate consistently elevated results with higher score values. Sensitivity analyses did not alter these results. Conclusion Occupational exposure to EDC was not associated with an increased risk for uveal melanoma. (Less)
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published
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keywords
cancer, EDC, endocrine-distrupting agent, exposure score, eye melanoma, multicenter study, ocular melanoma, rare cancer, solvent, xenoestrogen
in
Scandinavian Journal of Work, Environment and Health
volume
38
issue
5
pages
476 - 483
publisher
Finnish Institute of Occupational Health
external identifiers
  • wos:000308570400010
  • scopus:84865858356
ISSN
0355-3140
DOI
10.5271/sjweh.3265
language
English
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yes
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aa2c0ef9-52ac-436d-950d-9ff1b0b6ccb6 (old id 3139733)
date added to LUP
2012-11-01 11:20:50
date last changed
2017-08-13 03:18:09
@article{aa2c0ef9-52ac-436d-950d-9ff1b0b6ccb6,
  abstract     = {Objectives We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case control study from nine European countries. Methods After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure. Results The overall exposure prevalence to EDC was low reaching a maximum of 11% for heavy metals with endocrine-disrupting properties. Although working in some industries was associated with increased melanoma risk [such as dry cleaning: odds ratio (OR) 6.15, 95% confidence interval (95% CI) 2.0-18.96 and working in the glass manufacturing industry: OR 3.49, 95% CI 1.10-11.10], agent-specific risks were not elevated. The strongest possible risk increase was observed for organic solvents with endocrine-disrupting properties (OR 1.31, 95% CI 0.78-2.21). Calculation of exposure scores did not indicate consistently elevated results with higher score values. Sensitivity analyses did not alter these results. Conclusion Occupational exposure to EDC was not associated with an increased risk for uveal melanoma.},
  author       = {Behrens, Thomas and Lynge, Elsebeth and Cree, Ian and Lutz, Jean-Michel and Eriksson, Mikael and Guenel, Pascal and Merletti, Franco and Morales-Suarez-Varela, Maria and Afonso, Noemia and Stengrevics, Aivars and Stang, Andreas and Fevotte, Joelle and Sabroe, Svend and Llopis-Gonzalez, Agustin and Gorini, Giuseppe and Hardell, Lennart and Ahrens, Wolfgang},
  issn         = {0355-3140},
  keyword      = {cancer,EDC,endocrine-distrupting agent,exposure score,eye melanoma,multicenter study,ocular melanoma,rare cancer,solvent,xenoestrogen},
  language     = {eng},
  number       = {5},
  pages        = {476--483},
  publisher    = {Finnish Institute of Occupational Health},
  series       = {Scandinavian Journal of Work, Environment and Health},
  title        = {Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma},
  url          = {http://dx.doi.org/10.5271/sjweh.3265},
  volume       = {38},
  year         = {2012},
}