Alternatively folded proteins with unexpected beneficial functions
(2012) In Biochemical Society Transactions 40. p.746-751- Abstract
- HAMLET (human alpha-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3147216
- author
- Min, Soyoung ; Meehan, James ; Sullivan, Louise M. ; Harte, Nial P. ; Xie, Yongjing ; Davey, Gavin P. ; Svanborg, Catharina LU ; Brodkorb, Andre and Mok, Ken LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alternatively folded protein, bovine alpha-lactalbumin made lethal to, tumour cells (BAMLET), equine lysozyme with oleic acid (ELOA), human, alpha-lactalbumin made lethal to tumour cells (HAMLET), multimeric, alpha-lactalbumin (MAL).
- in
- Biochemical Society Transactions
- volume
- 40
- pages
- 746 - 751
- publisher
- Biochemical Society
- external identifiers
-
- wos:000307431700027
- scopus:84864384095
- pmid:22817727
- ISSN
- 0300-5127
- DOI
- 10.1042/BST20120029
- language
- English
- LU publication?
- yes
- id
- 82b1a893-dde5-43b9-a69d-72f971f2d74d (old id 3147216)
- date added to LUP
- 2016-04-01 09:57:39
- date last changed
- 2022-02-09 21:21:41
@article{82b1a893-dde5-43b9-a69d-72f971f2d74d, abstract = {{HAMLET (human alpha-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.}}, author = {{Min, Soyoung and Meehan, James and Sullivan, Louise M. and Harte, Nial P. and Xie, Yongjing and Davey, Gavin P. and Svanborg, Catharina and Brodkorb, Andre and Mok, Ken}}, issn = {{0300-5127}}, keywords = {{alternatively folded protein; bovine alpha-lactalbumin made lethal to; tumour cells (BAMLET); equine lysozyme with oleic acid (ELOA); human; alpha-lactalbumin made lethal to tumour cells (HAMLET); multimeric; alpha-lactalbumin (MAL).}}, language = {{eng}}, pages = {{746--751}}, publisher = {{Biochemical Society}}, series = {{Biochemical Society Transactions}}, title = {{Alternatively folded proteins with unexpected beneficial functions}}, url = {{https://lup.lub.lu.se/search/files/1425505/3165416.pdf}}, doi = {{10.1042/BST20120029}}, volume = {{40}}, year = {{2012}}, }