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Alternatively folded proteins with unexpected beneficial functions

Min, Soyoung; Meehan, James; Sullivan, Louise M.; Harte, Nial P.; Xie, Yongjing; Davey, Gavin P.; Svanborg, Catharina LU ; Brodkorb, Andre and Mok, Ken LU (2012) In Biochemical Society Transactions 40. p.746-751
Abstract
HAMLET (human alpha-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alternatively folded protein, bovine alpha-lactalbumin made lethal to, tumour cells (BAMLET), equine lysozyme with oleic acid (ELOA), human, alpha-lactalbumin made lethal to tumour cells (HAMLET), multimeric, alpha-lactalbumin (MAL).
in
Biochemical Society Transactions
volume
40
pages
746 - 751
publisher
Biochemical Society
external identifiers
  • wos:000307431700027
  • scopus:84864384095
ISSN
0300-5127
DOI
10.1042/BST20120029
language
English
LU publication?
yes
id
82b1a893-dde5-43b9-a69d-72f971f2d74d (old id 3147216)
date added to LUP
2012-11-01 09:59:17
date last changed
2017-11-19 03:02:58
@article{82b1a893-dde5-43b9-a69d-72f971f2d74d,
  abstract     = {HAMLET (human alpha-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.},
  author       = {Min, Soyoung and Meehan, James and Sullivan, Louise M. and Harte, Nial P. and Xie, Yongjing and Davey, Gavin P. and Svanborg, Catharina and Brodkorb, Andre and Mok, Ken},
  issn         = {0300-5127},
  keyword      = {alternatively folded protein,bovine alpha-lactalbumin made lethal to,tumour cells (BAMLET),equine lysozyme with oleic acid (ELOA),human,alpha-lactalbumin made lethal to tumour cells (HAMLET),multimeric,alpha-lactalbumin (MAL).},
  language     = {eng},
  pages        = {746--751},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {Alternatively folded proteins with unexpected beneficial functions},
  url          = {http://dx.doi.org/10.1042/BST20120029},
  volume       = {40},
  year         = {2012},
}