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The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes

Ahlen, Maria Therese; Husebekk, Anne; Killie, Mette Kjaer; Kjeldsen-Kragh, Jens; Olsson, Martin L LU and Skogen, Bjorn (2012) In Clinical & Developmental Immunology
Abstract
Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI... (More)
Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25-0.75). Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side. (Less)
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organization
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Contribution to journal
publication status
published
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Clinical & Developmental Immunology
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000308591400001
  • scopus:84855173320
ISSN
1740-2530
DOI
10.1155/2012/156867
language
English
LU publication?
yes
id
f078ed56-84af-4376-8f9d-c3f1f96e966c (old id 3147373)
date added to LUP
2012-11-01 09:49:34
date last changed
2017-08-20 03:26:54
@article{f078ed56-84af-4376-8f9d-c3f1f96e966c,
  abstract     = {Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25-0.75). Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side.},
  articleno    = {156867},
  author       = {Ahlen, Maria Therese and Husebekk, Anne and Killie, Mette Kjaer and Kjeldsen-Kragh, Jens and Olsson, Martin L and Skogen, Bjorn},
  issn         = {1740-2530},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Clinical & Developmental Immunology},
  title        = {The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes},
  url          = {http://dx.doi.org/10.1155/2012/156867},
  year         = {2012},
}