The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes
(2012) In Clinical & Developmental Immunology- Abstract
- Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI... (More)
- Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25-0.75). Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3147373
- author
- Ahlen, Maria Therese ; Husebekk, Anne ; Killie, Mette Kjaer ; Kjeldsen-Kragh, Jens ; Olsson, Martin L LU and Skogen, Bjorn
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical & Developmental Immunology
- article number
- 156867
- publisher
- Hindawi Limited
- external identifiers
-
- wos:000308591400001
- scopus:84855173320
- pmid:22110529
- ISSN
- 1740-2530
- DOI
- 10.1155/2012/156867
- language
- English
- LU publication?
- yes
- id
- f078ed56-84af-4376-8f9d-c3f1f96e966c (old id 3147373)
- date added to LUP
- 2016-04-01 11:15:29
- date last changed
- 2022-01-26 06:35:36
@article{f078ed56-84af-4376-8f9d-c3f1f96e966c, abstract = {{Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25-0.75). Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side.}}, author = {{Ahlen, Maria Therese and Husebekk, Anne and Killie, Mette Kjaer and Kjeldsen-Kragh, Jens and Olsson, Martin L and Skogen, Bjorn}}, issn = {{1740-2530}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{Clinical & Developmental Immunology}}, title = {{The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes}}, url = {{https://lup.lub.lu.se/search/files/2511760/3173739.pdf}}, doi = {{10.1155/2012/156867}}, year = {{2012}}, }