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Association of an Osteopontin gene promoter polymorphism with susceptibility to diabetic nephropathy in Asian Indians

Cheema, Balneek Singh; Iyengar, Sreenivasa; Ahluwalia, Tarun LU ; Kohli, Harbir Singh; Sharma, Rajni; Shah, Viral N.; Bhansali, Anil; Sakhuja, V. and Khullar, Madhu (2012) In Clinica Chimica Acta 413(19-20). p.1600-1604
Abstract
Genetic predisposition has been proposed to be a major determinant in the development of renal complications of diabetes. Osteopontin (OPN) has been suggested to be associated with renal diseases characterized by tubulointerstitial fibrosis and proteinuria. However, information on association of genetic polymorphisms in OPN with diabetic nephropathy is lacking. Thus, the present study was designed with the aim to examine the association of an OPN gene promoter polymorphism with diabetic nephropathy in Asian Indians. OPN C-443T (rs11730582) polymorphism was determined in 1115 type 2 diabetic patients belonging to two independently ascertained cohorts using Real time PCR based Taqman assay. We observed a nearly threefold elevated risk of... (More)
Genetic predisposition has been proposed to be a major determinant in the development of renal complications of diabetes. Osteopontin (OPN) has been suggested to be associated with renal diseases characterized by tubulointerstitial fibrosis and proteinuria. However, information on association of genetic polymorphisms in OPN with diabetic nephropathy is lacking. Thus, the present study was designed with the aim to examine the association of an OPN gene promoter polymorphism with diabetic nephropathy in Asian Indians. OPN C-443T (rs11730582) polymorphism was determined in 1115 type 2 diabetic patients belonging to two independently ascertained cohorts using Real time PCR based Taqman assay. We observed a nearly threefold elevated risk of diabetic nephropathy among carriers of T allele and TT genotype of OPN C-443T polymorphism. Further, this allele was found to be significantly associated with proteinuria and lower eGFR, a hallmark of diabetic nephropathy, in both our cohorts. This is the first study which suggests that OPN C-443T polymorphism may be a significant risk factor for diabetic nephropathy in type 2 diabetic patients. (C) 2012 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Osteopontin, Genetic polymorphism, Type 2 diabetes, Diabetic nephropathy
in
Clinica Chimica Acta
volume
413
issue
19-20
pages
1600 - 1604
publisher
Elsevier
external identifiers
  • wos:000307924000031
  • scopus:84864387578
ISSN
0009-8981
DOI
10.1016/j.cca.2012.04.028
language
English
LU publication?
yes
id
cd187d80-07dd-4076-a821-fd13ce2f2969 (old id 3147484)
date added to LUP
2012-11-01 09:40:10
date last changed
2017-01-01 03:39:42
@article{cd187d80-07dd-4076-a821-fd13ce2f2969,
  abstract     = {Genetic predisposition has been proposed to be a major determinant in the development of renal complications of diabetes. Osteopontin (OPN) has been suggested to be associated with renal diseases characterized by tubulointerstitial fibrosis and proteinuria. However, information on association of genetic polymorphisms in OPN with diabetic nephropathy is lacking. Thus, the present study was designed with the aim to examine the association of an OPN gene promoter polymorphism with diabetic nephropathy in Asian Indians. OPN C-443T (rs11730582) polymorphism was determined in 1115 type 2 diabetic patients belonging to two independently ascertained cohorts using Real time PCR based Taqman assay. We observed a nearly threefold elevated risk of diabetic nephropathy among carriers of T allele and TT genotype of OPN C-443T polymorphism. Further, this allele was found to be significantly associated with proteinuria and lower eGFR, a hallmark of diabetic nephropathy, in both our cohorts. This is the first study which suggests that OPN C-443T polymorphism may be a significant risk factor for diabetic nephropathy in type 2 diabetic patients. (C) 2012 Elsevier B.V. All rights reserved.},
  author       = {Cheema, Balneek Singh and Iyengar, Sreenivasa and Ahluwalia, Tarun and Kohli, Harbir Singh and Sharma, Rajni and Shah, Viral N. and Bhansali, Anil and Sakhuja, V. and Khullar, Madhu},
  issn         = {0009-8981},
  keyword      = {Osteopontin,Genetic polymorphism,Type 2 diabetes,Diabetic nephropathy},
  language     = {eng},
  number       = {19-20},
  pages        = {1600--1604},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Association of an Osteopontin gene promoter polymorphism with susceptibility to diabetic nephropathy in Asian Indians},
  url          = {http://dx.doi.org/10.1016/j.cca.2012.04.028},
  volume       = {413},
  year         = {2012},
}