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Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)

Nagel, Gabriele; Stocks, Tanja; Spaeth, Daniela; Hjartaker, Anette; Lindkvist, Bjorn; Hallmans, Goran; Jonsson, Hakan; Bjorge, Tone; Manjer, Jonas LU and Haggstrom, Christel, et al. (2012) In Annals of Hematology 91(10). p.1519-1531
Abstract
We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p = 0.002), lymphoid neoplasms (p = 0.01), and Hodgkin's lymphoma (p = 0.02) in women. Further associations with BMI were found for high-grade B-cell... (More)
We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p = 0.002), lymphoid neoplasms (p = 0.01), and Hodgkin's lymphoma (p = 0.02) in women. Further associations with BMI were found for high-grade B-cell lymphoma (p = 0.02) and chronic lymphatic leukemia in men (p = 0.05) and women (p = 0.01). Higher cholesterol levels were inversely associated with myeloid neoplasms in women (p = 0.01), particularly acute myeloid leukemia (p = 0.003), and glucose was positively associated with chronic myeloid leukemia in women (p = 0.03). In men, glucose was positively associated with risk of high-grade B-cell lymphoma and multiple myeloma, while cholesterol was inversely associated with low-grade B-cell lymphoma. The metabolic syndrome score was related to 48 % increased risk of Hodgkin's lymphoma among women. BMI showed up as the most consistent risk factor, particularly in women. A clear pattern was not found for other metabolic factors. (Less)
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keywords
Cancer, Biomarker, Epidemiology, Leukemia, Lymphoma
in
Annals of Hematology
volume
91
issue
10
pages
1519 - 1531
publisher
Springer Verlag
external identifiers
  • wos:000308356900002
  • scopus:84867336658
ISSN
1432-0584
DOI
10.1007/s00277-012-1489-z
language
English
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yes
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c1ba4391-541e-40ce-b9e4-4f2aef133be5 (old id 3147495)
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2012-11-01 09:42:10
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@article{c1ba4391-541e-40ce-b9e4-4f2aef133be5,
  abstract     = {We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p = 0.002), lymphoid neoplasms (p = 0.01), and Hodgkin's lymphoma (p = 0.02) in women. Further associations with BMI were found for high-grade B-cell lymphoma (p = 0.02) and chronic lymphatic leukemia in men (p = 0.05) and women (p = 0.01). Higher cholesterol levels were inversely associated with myeloid neoplasms in women (p = 0.01), particularly acute myeloid leukemia (p = 0.003), and glucose was positively associated with chronic myeloid leukemia in women (p = 0.03). In men, glucose was positively associated with risk of high-grade B-cell lymphoma and multiple myeloma, while cholesterol was inversely associated with low-grade B-cell lymphoma. The metabolic syndrome score was related to 48 % increased risk of Hodgkin's lymphoma among women. BMI showed up as the most consistent risk factor, particularly in women. A clear pattern was not found for other metabolic factors.},
  author       = {Nagel, Gabriele and Stocks, Tanja and Spaeth, Daniela and Hjartaker, Anette and Lindkvist, Bjorn and Hallmans, Goran and Jonsson, Hakan and Bjorge, Tone and Manjer, Jonas and Haggstrom, Christel and Engeland, Anders and Ulmer, Hanno and Selmer, Randi and Concin, Hans and Stattin, Paer and Schlenk, Richard F.},
  issn         = {1432-0584},
  keyword      = {Cancer,Biomarker,Epidemiology,Leukemia,Lymphoma},
  language     = {eng},
  number       = {10},
  pages        = {1519--1531},
  publisher    = {Springer Verlag},
  series       = {Annals of Hematology},
  title        = {Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)},
  url          = {http://dx.doi.org/10.1007/s00277-012-1489-z},
  volume       = {91},
  year         = {2012},
}