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Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?

Machaczka, Maciej; Johansson, Jan-Erik; Remberger, Mats; Hallbook, Helene; Malm, Claes; Lazarevic, Vladimir LU ; Wahlin, Anders; Omar, Hamdy; Juliusson, Gunnar LU and Kimby, Eva, et al. (2012) In Leukemia & Lymphoma 53(9). p.1699-1705
Abstract
Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved > 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with <= 90% donor T-cell... (More)
Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved > 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with <= 90% donor T-cell engraftment, they showed favorable PFS at 1 year (82% vs. 33%, p = 0.002) and better long-term PFS and OS (p = 0.002 and 0.046, respectively). Donor T-cell engraftment of > 90% at 3 months after RIC allo-SCT for CLL seems to predict favorable short-term and long-term outcome. (Less)
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publication status
published
subject
keywords
Allogeneic stem cell transplant, chronic lymphocytic leukemia, T-cell, donor engraftment
in
Leukemia & Lymphoma
volume
53
issue
9
pages
1699 - 1705
publisher
Taylor & Francis
external identifiers
  • wos:000307301500012
  • scopus:84864996370
ISSN
1042-8194
DOI
10.3109/10428194.2012.666661
language
English
LU publication?
yes
id
abcb9dd8-0e09-4089-b0f7-e7fdf9cd4a9a (old id 3147742)
date added to LUP
2012-11-01 09:32:52
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2017-01-01 05:25:44
@article{abcb9dd8-0e09-4089-b0f7-e7fdf9cd4a9a,
  abstract     = {Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved &gt; 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with &lt;= 90% donor T-cell engraftment, they showed favorable PFS at 1 year (82% vs. 33%, p = 0.002) and better long-term PFS and OS (p = 0.002 and 0.046, respectively). Donor T-cell engraftment of &gt; 90% at 3 months after RIC allo-SCT for CLL seems to predict favorable short-term and long-term outcome.},
  author       = {Machaczka, Maciej and Johansson, Jan-Erik and Remberger, Mats and Hallbook, Helene and Malm, Claes and Lazarevic, Vladimir and Wahlin, Anders and Omar, Hamdy and Juliusson, Gunnar and Kimby, Eva and Hagglund, Hans},
  issn         = {1042-8194},
  keyword      = {Allogeneic stem cell transplant,chronic lymphocytic leukemia,T-cell,donor engraftment},
  language     = {eng},
  number       = {9},
  pages        = {1699--1705},
  publisher    = {Taylor & Francis},
  series       = {Leukemia & Lymphoma},
  title        = {Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?},
  url          = {http://dx.doi.org/10.3109/10428194.2012.666661},
  volume       = {53},
  year         = {2012},
}