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An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane- 2,6-dione

Almqvist, Fredrik; Eklund, Lars and Frejd, Torbjörn LU (1993) In Synthetic Communications 23(11). p.1499-1505
Abstract
Conjugate addition of Meldrum's acid to 2-cyclohexenone followed by direct cyclization in PPA/acetic acid constitutes a shorter, more reproducible and higher yielding route to bicyclo[2.2.2]octane-2,6-dione than previous methods. The crude dione could be used as substrate for the baker's yeast reduction to (IR, 4S, 6S)-bicyclo[2.2.2]octane-6-ol-2-one.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Synthetic Communications
volume
23
issue
11
pages
1499 - 1505
publisher
Marcel Dekker
external identifiers
  • scopus:0027319329
ISSN
0039-7911
DOI
10.1080/00397919308011243
language
English
LU publication?
yes
id
f6232f39-ddb5-432a-b667-e12c4420bc7a (old id 31490)
date added to LUP
2007-06-19 14:27:26
date last changed
2017-01-01 07:16:46
@article{f6232f39-ddb5-432a-b667-e12c4420bc7a,
  abstract     = {Conjugate addition of Meldrum's acid to 2-cyclohexenone followed by direct cyclization in PPA/acetic acid constitutes a shorter, more reproducible and higher yielding route to bicyclo[2.2.2]octane-2,6-dione than previous methods. The crude dione could be used as substrate for the baker's yeast reduction to (IR, 4S, 6S)-bicyclo[2.2.2]octane-6-ol-2-one.},
  author       = {Almqvist, Fredrik and Eklund, Lars and Frejd, Torbjörn},
  issn         = {0039-7911},
  language     = {eng},
  number       = {11},
  pages        = {1499--1505},
  publisher    = {Marcel Dekker},
  series       = {Synthetic Communications},
  title        = {An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane- 2,6-dione},
  url          = {http://dx.doi.org/10.1080/00397919308011243},
  volume       = {23},
  year         = {1993},
}