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Meniscus Body Position, Size, and Shape in Persons With and Persons Without Radiographic Knee Osteoarthritis: Quantitative Analyses of Knee Magnetic Resonance Images From the Osteoarthritis Initiative

Wenger, Andrea; Wirth, Wolfgang; Hudelmaier, Martin; Noebauer-Huhmann, Iris; Trattnig, Siegfried; Bloecker, Katja; Frobell, Richard LU ; Kwoh, C. Kent; Eckstein, Felix and Englund, Martin LU (2013) In Arthritis and Rheumatism 65(7). p.1804-1811
Abstract
ObjectiveTo quantitatively evaluate the position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects without OA, using magnetic resonance imaging (MRI). MethodsWe studied the right knees of 39 Osteoarthritis Initiative participants (24 women and 15 men with a mean age of 59.6 +/- 8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren/Lawrence grade of 2 or 3). Subjects were matched individually for age, sex, and height to controls without knee OA and without risk factors for knee OA. The right knees of the controls were used as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on a coronally... (More)
ObjectiveTo quantitatively evaluate the position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects without OA, using magnetic resonance imaging (MRI). MethodsWe studied the right knees of 39 Osteoarthritis Initiative participants (24 women and 15 men with a mean age of 59.6 +/- 8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren/Lawrence grade of 2 or 3). Subjects were matched individually for age, sex, and height to controls without knee OA and without risk factors for knee OA. The right knees of the controls were used as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on a coronally reconstructed double-echo steady-state sequence with water excitation, focusing on 5 central 3T MRIs. ResultsIn OA knees, there was less meniscal coverage of the medial tibial plateau (435 mm(2) versus 515 mm(2); P = 0.0004), the medial meniscus body showed more extrusion (2.64 mm versus 0.53 mm; P < 0.0001), and the peripheral margin had a more convex shape, i.e., bulged more (mean 0.61 mm versus 0.27 mm; P < 0.0001). The thickness or volume of the medial meniscus body of OA knees did not differ substantially from reference knees. In contrast, in OA knees the lateral meniscus body had a larger volume (mean 266 mm(3) versus 224 mm(3); P = 0.0005) and extruded more (mean 1.16 mm versus -1.01 mm; P < 0.0001), and the external margin bulged more (mean 0.53 mm versus 0.35 mm; P < 0.0001), than in reference knees. ConclusionOur findings indicate altered meniscal position and shape (i.e., more bulging) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
65
issue
7
pages
1804 - 1811
publisher
John Wiley & Sons
external identifiers
  • wos:000322155000016
  • scopus:84879866219
ISSN
1529-0131
DOI
10.1002/art.37947
language
English
LU publication?
yes
id
314ae56c-e5cd-49cb-b1c0-46ad19ed1b6d (old id 4053389)
date added to LUP
2013-10-01 15:18:30
date last changed
2019-04-23 01:31:53
@article{314ae56c-e5cd-49cb-b1c0-46ad19ed1b6d,
  abstract     = {ObjectiveTo quantitatively evaluate the position, size, and shape of the menisci in subjects with radiographic knee osteoarthritis (OA) compared to subjects without OA, using magnetic resonance imaging (MRI). MethodsWe studied the right knees of 39 Osteoarthritis Initiative participants (24 women and 15 men with a mean age of 59.6 +/- 8.7 years) with medial compartment radiographic tibiofemoral OA (Kellgren/Lawrence grade of 2 or 3). Subjects were matched individually for age, sex, and height to controls without knee OA and without risk factors for knee OA. The right knees of the controls were used as references. One observer performed manual segmentation of the tibial plateau and the medial and lateral meniscus based on a coronally reconstructed double-echo steady-state sequence with water excitation, focusing on 5 central 3T MRIs. ResultsIn OA knees, there was less meniscal coverage of the medial tibial plateau (435 mm(2) versus 515 mm(2); P = 0.0004), the medial meniscus body showed more extrusion (2.64 mm versus 0.53 mm; P &lt; 0.0001), and the peripheral margin had a more convex shape, i.e., bulged more (mean 0.61 mm versus 0.27 mm; P &lt; 0.0001). The thickness or volume of the medial meniscus body of OA knees did not differ substantially from reference knees. In contrast, in OA knees the lateral meniscus body had a larger volume (mean 266 mm(3) versus 224 mm(3); P = 0.0005) and extruded more (mean 1.16 mm versus -1.01 mm; P &lt; 0.0001), and the external margin bulged more (mean 0.53 mm versus 0.35 mm; P &lt; 0.0001), than in reference knees. ConclusionOur findings indicate altered meniscal position and shape (i.e., more bulging) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences.},
  author       = {Wenger, Andrea and Wirth, Wolfgang and Hudelmaier, Martin and Noebauer-Huhmann, Iris and Trattnig, Siegfried and Bloecker, Katja and Frobell, Richard and Kwoh, C. Kent and Eckstein, Felix and Englund, Martin},
  issn         = {1529-0131},
  language     = {eng},
  number       = {7},
  pages        = {1804--1811},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis and Rheumatism},
  title        = {Meniscus Body Position, Size, and Shape in Persons With and Persons Without Radiographic Knee Osteoarthritis: Quantitative Analyses of Knee Magnetic Resonance Images From the Osteoarthritis Initiative},
  url          = {http://dx.doi.org/10.1002/art.37947},
  volume       = {65},
  year         = {2013},
}