Sensitization and cross-reactivity patterns of contact allergy to diisocyanates and corresponding amines : Investigation of diphenylmethane-4,4'-diisocyanate, diphenylmethane-4,4'-diamine, dicyclohexylmethane-4,4'-diisocyanate, and dicylohexylmethane-4,4'-diamine
(2017) In Contact Dermatitis 77(4). p.231-241- Abstract
Background: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI). Objectives: To investigate the sensitization capacities and the cross-reactivity of 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and dicyclohexylmethane-4,4'-diamine (4,4'-DMDA). Methods: The guinea-pig maximization test (GPMT) was used.... (More)
Background: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI). Objectives: To investigate the sensitization capacities and the cross-reactivity of 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and dicyclohexylmethane-4,4'-diamine (4,4'-DMDA). Methods: The guinea-pig maximization test (GPMT) was used. Results: The GPMT showed sensitizing capacities for all investigated substances: 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and 4,4'-DMDA (all p < 0.001). 4,4'-MDI-sensitized animals showed cross-reactivity to 4,4'-MDA (p < 0.001) and 4,4'-DMDI (all p < 0.05). 4,4'-MDA-sensitized animals showed cross-reactivity to 4,4'-DMDA (p = 0.008). Conclusion: All of the investigated substances were shown to be strong sensitizers. Animals sensitized to 4,4'-MDI showed cross-reactivity to 4,4'-MDA and 4,4'-DMDI, supporting previous findings in the literature. The aromatic amine 4,4'-MDA showed cross-reactivity to the aliphatic amine 4,4'-DMDA.
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- author
- Hamada, Haneen LU ; Bruze, Magnus LU ; Zimerson, Erik LU ; Isaksson, Marléne LU and Engfeldt, Malin LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 4,4'-DMDA, 4,4'-DMDI, 4,4'-MDA, 4,4'-MDI, Allergic contact dermatitis, Amines, Cross-reactions, Guinea-pig maximization test, Isocyanates, Occupational
- in
- Contact Dermatitis
- volume
- 77
- issue
- 4
- pages
- 231 - 241
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85019763316
- pmid:28555927
- wos:000409110100006
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.12809
- project
- PhD
- language
- English
- LU publication?
- yes
- id
- 3152d427-7ab3-4213-986f-529c8aa93d09
- date added to LUP
- 2017-06-16 13:16:05
- date last changed
- 2025-02-03 18:02:41
@article{3152d427-7ab3-4213-986f-529c8aa93d09, abstract = {{<p>Background: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI). Objectives: To investigate the sensitization capacities and the cross-reactivity of 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and dicyclohexylmethane-4,4'-diamine (4,4'-DMDA). Methods: The guinea-pig maximization test (GPMT) was used. Results: The GPMT showed sensitizing capacities for all investigated substances: 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and 4,4'-DMDA (all p < 0.001). 4,4'-MDI-sensitized animals showed cross-reactivity to 4,4'-MDA (p < 0.001) and 4,4'-DMDI (all p < 0.05). 4,4'-MDA-sensitized animals showed cross-reactivity to 4,4'-DMDA (p = 0.008). Conclusion: All of the investigated substances were shown to be strong sensitizers. Animals sensitized to 4,4'-MDI showed cross-reactivity to 4,4'-MDA and 4,4'-DMDI, supporting previous findings in the literature. The aromatic amine 4,4'-MDA showed cross-reactivity to the aliphatic amine 4,4'-DMDA.</p>}}, author = {{Hamada, Haneen and Bruze, Magnus and Zimerson, Erik and Isaksson, Marléne and Engfeldt, Malin}}, issn = {{0105-1873}}, keywords = {{4,4'-DMDA; 4,4'-DMDI; 4,4'-MDA; 4,4'-MDI; Allergic contact dermatitis; Amines; Cross-reactions; Guinea-pig maximization test; Isocyanates; Occupational}}, language = {{eng}}, number = {{4}}, pages = {{231--241}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Sensitization and cross-reactivity patterns of contact allergy to diisocyanates and corresponding amines : Investigation of diphenylmethane-4,4'-diisocyanate, diphenylmethane-4,4'-diamine, dicyclohexylmethane-4,4'-diisocyanate, and dicylohexylmethane-4,4'-diamine}}, url = {{http://dx.doi.org/10.1111/cod.12809}}, doi = {{10.1111/cod.12809}}, volume = {{77}}, year = {{2017}}, }