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Sensitization and cross-reactivity patterns of contact allergy to diisocyanates and corresponding amines : Investigation of diphenylmethane-4,4'-diisocyanate, diphenylmethane-4,4'-diamine, dicyclohexylmethane-4,4'-diisocyanate, and dicylohexylmethane-4,4'-diamine

Hamada, Haneen LU ; Bruze, Magnus LU ; Zimerson, Erik LU ; Isaksson, Marléne LU and Engfeldt, Malin LU (2017) In Contact Dermatitis 77(4). p.231-241
Abstract

Background: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI). Objectives: To investigate the sensitization capacities and the cross-reactivity of 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and dicyclohexylmethane-4,4'-diamine (4,4'-DMDA). Methods: The guinea-pig maximization test (GPMT) was used.... (More)

Background: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI). Objectives: To investigate the sensitization capacities and the cross-reactivity of 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and dicyclohexylmethane-4,4'-diamine (4,4'-DMDA). Methods: The guinea-pig maximization test (GPMT) was used. Results: The GPMT showed sensitizing capacities for all investigated substances: 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and 4,4'-DMDA (all p < 0.001). 4,4'-MDI-sensitized animals showed cross-reactivity to 4,4'-MDA (p < 0.001) and 4,4'-DMDI (all p < 0.05). 4,4'-MDA-sensitized animals showed cross-reactivity to 4,4'-DMDA (p = 0.008). Conclusion: All of the investigated substances were shown to be strong sensitizers. Animals sensitized to 4,4'-MDI showed cross-reactivity to 4,4'-MDA and 4,4'-DMDI, supporting previous findings in the literature. The aromatic amine 4,4'-MDA showed cross-reactivity to the aliphatic amine 4,4'-DMDA.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
4,4'-DMDA, 4,4'-DMDI, 4,4'-MDA, 4,4'-MDI, Allergic contact dermatitis, Amines, Cross-reactions, Guinea-pig maximization test, Isocyanates, Occupational
in
Contact Dermatitis
volume
77
issue
4
pages
231 - 241
publisher
Wiley-Blackwell
external identifiers
  • pmid:28555927
  • wos:000409110100006
  • scopus:85019763316
ISSN
0105-1873
DOI
10.1111/cod.12809
project
PhD
language
English
LU publication?
yes
id
3152d427-7ab3-4213-986f-529c8aa93d09
date added to LUP
2017-06-16 13:16:05
date last changed
2024-05-26 17:42:33
@article{3152d427-7ab3-4213-986f-529c8aa93d09,
  abstract     = {{<p>Background: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI). Objectives: To investigate the sensitization capacities and the cross-reactivity of 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and dicyclohexylmethane-4,4'-diamine (4,4'-DMDA). Methods: The guinea-pig maximization test (GPMT) was used. Results: The GPMT showed sensitizing capacities for all investigated substances: 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and 4,4'-DMDA (all p &lt; 0.001). 4,4'-MDI-sensitized animals showed cross-reactivity to 4,4'-MDA (p &lt; 0.001) and 4,4'-DMDI (all p &lt; 0.05). 4,4'-MDA-sensitized animals showed cross-reactivity to 4,4'-DMDA (p = 0.008). Conclusion: All of the investigated substances were shown to be strong sensitizers. Animals sensitized to 4,4'-MDI showed cross-reactivity to 4,4'-MDA and 4,4'-DMDI, supporting previous findings in the literature. The aromatic amine 4,4'-MDA showed cross-reactivity to the aliphatic amine 4,4'-DMDA.</p>}},
  author       = {{Hamada, Haneen and Bruze, Magnus and Zimerson, Erik and Isaksson, Marléne and Engfeldt, Malin}},
  issn         = {{0105-1873}},
  keywords     = {{4,4'-DMDA; 4,4'-DMDI; 4,4'-MDA; 4,4'-MDI; Allergic contact dermatitis; Amines; Cross-reactions; Guinea-pig maximization test; Isocyanates; Occupational}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{231--241}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Sensitization and cross-reactivity patterns of contact allergy to diisocyanates and corresponding amines : Investigation of diphenylmethane-4,4'-diisocyanate, diphenylmethane-4,4'-diamine, dicyclohexylmethane-4,4'-diisocyanate, and dicylohexylmethane-4,4'-diamine}},
  url          = {{http://dx.doi.org/10.1111/cod.12809}},
  doi          = {{10.1111/cod.12809}},
  volume       = {{77}},
  year         = {{2017}},
}