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An electrochemical-cantilever hybrid sensor for metal ions

Fischer, Lee MacKenzie; Dohn, S.; Boisen, Anja and Tenje, Maria LU (2010) IEEE Sensors In [Host publication title missing] p.913-917
Abstract
In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.
Please use this url to cite or link to this publication:
author
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
[Host publication title missing]
pages
913 - 917
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
IEEE Sensors
external identifiers
  • Scopus:79951879739
ISBN
978-1-4244-8170-5
DOI
10.1109/ICSENS.2010.5690884
language
English
LU publication?
no
id
474c4f4d-f77e-4d5e-93ac-5fcf97580f2c (old id 3164929)
date added to LUP
2012-11-08 13:20:22
date last changed
2017-01-01 08:04:42
@inproceedings{474c4f4d-f77e-4d5e-93ac-5fcf97580f2c,
  abstract     = {In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.},
  author       = {Fischer, Lee MacKenzie and Dohn, S. and Boisen, Anja and Tenje, Maria},
  booktitle    = {[Host publication title missing]},
  isbn         = {978-1-4244-8170-5},
  language     = {eng},
  pages        = {913--917},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  title        = {An electrochemical-cantilever hybrid sensor for metal ions},
  url          = {http://dx.doi.org/10.1109/ICSENS.2010.5690884},
  year         = {2010},
}