Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas
(1988) In Acta Endocrinologica 117(3). p.302-306- Abstract
The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 μg/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P < 0.05). In addition, 26 μg/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3166aa9c-002d-4aed-976a-ff7674ba2769
- author
- Wogensen, L. D.
; Mandrup-Poulsen, T.
; Markholst, H.
; Molvig, J.
; Lernmark, A.
LU
; Holst, J. J. LU ; Dinarello, C. A. and Nerup, J. LU
- publishing date
- 1988-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Acta Endocrinologica
- volume
- 117
- issue
- 3
- pages
- 5 pages
- publisher
- Society of the European Journal of Endocrinology
- external identifiers
-
- scopus:0023841393
- pmid:3289298
- ISSN
- 0001-5598
- DOI
- 10.1530/acta.0.1170302
- language
- English
- LU publication?
- no
- id
- 3166aa9c-002d-4aed-976a-ff7674ba2769
- date added to LUP
- 2019-09-11 10:04:10
- date last changed
- 2024-03-13 08:18:39
@article{3166aa9c-002d-4aed-976a-ff7674ba2769, abstract = {{<p>The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 μg/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P < 0.05). In addition, 26 μg/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.</p>}}, author = {{Wogensen, L. D. and Mandrup-Poulsen, T. and Markholst, H. and Molvig, J. and Lernmark, A. and Holst, J. J. and Dinarello, C. A. and Nerup, J.}}, issn = {{0001-5598}}, language = {{eng}}, month = {{01}}, number = {{3}}, pages = {{302--306}}, publisher = {{Society of the European Journal of Endocrinology}}, series = {{Acta Endocrinologica}}, title = {{Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas}}, url = {{http://dx.doi.org/10.1530/acta.0.1170302}}, doi = {{10.1530/acta.0.1170302}}, volume = {{117}}, year = {{1988}}, }