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Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas

Wogensen, L. D. ; Mandrup-Poulsen, T. ; Markholst, H. ; Molvig, J. ; Lernmark, A. LU orcid ; Holst, J. J. LU ; Dinarello, C. A. and Nerup, J. LU (1988) In Acta Endocrinologica 117(3). p.302-306
Abstract

The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 μg/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P < 0.05). In addition, 26 μg/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Acta Endocrinologica
volume
117
issue
3
pages
5 pages
publisher
Society of the European Journal of Endocrinology
external identifiers
  • pmid:3289298
  • scopus:0023841393
ISSN
0001-5598
DOI
10.1530/acta.0.1170302
language
English
LU publication?
no
id
3166aa9c-002d-4aed-976a-ff7674ba2769
date added to LUP
2019-09-11 10:04:10
date last changed
2024-03-13 08:18:39
@article{3166aa9c-002d-4aed-976a-ff7674ba2769,
  abstract     = {{<p>The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 μg/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P &lt; 0.05). In addition, 26 μg/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.</p>}},
  author       = {{Wogensen, L. D. and Mandrup-Poulsen, T. and Markholst, H. and Molvig, J. and Lernmark, A. and Holst, J. J. and Dinarello, C. A. and Nerup, J.}},
  issn         = {{0001-5598}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{3}},
  pages        = {{302--306}},
  publisher    = {{Society of the European Journal of Endocrinology}},
  series       = {{Acta Endocrinologica}},
  title        = {{Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas}},
  url          = {{http://dx.doi.org/10.1530/acta.0.1170302}},
  doi          = {{10.1530/acta.0.1170302}},
  volume       = {{117}},
  year         = {{1988}},
}