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Planar gamma scintigraphy - points to consider when quantifying pulmonary dry powder aerosol deposition

Bondesson, Eva LU ; Bengtsson, T; Borgstrom, L; Nilsson, L; Norrgren, Kristina LU ; Trofast, E and Wollmer, Per LU (2003) In International Journal of Pharmaceutics 251(1-2). p.33-47
Abstract
Methodological aspects of planar gamma scintigraphy used to quantify pulmonary aerosol deposition were investigated using an experimental dry powder formulation. Particles of micronized salbutamol sulphate were labelled with technetium-99m and admixed to an ordered mixture of unlabelled micronized salbutamol sulphate and larger carrier particles of lactose. The radioaerosol was administered to 24 healthy subjects, 12 in each of two consecutive, similarly designed studies. Pulmonary deposition was determined using two methods: repeated planar imaging, and pharmacokinetic assessments following charcoal co-administration to prevent gastrointestinal salbutamol absorption. After due consideration had been taken to ensure appropriate... (More)
Methodological aspects of planar gamma scintigraphy used to quantify pulmonary aerosol deposition were investigated using an experimental dry powder formulation. Particles of micronized salbutamol sulphate were labelled with technetium-99m and admixed to an ordered mixture of unlabelled micronized salbutamol sulphate and larger carrier particles of lactose. The radioaerosol was administered to 24 healthy subjects, 12 in each of two consecutive, similarly designed studies. Pulmonary deposition was determined using two methods: repeated planar imaging, and pharmacokinetic assessments following charcoal co-administration to prevent gastrointestinal salbutamol absorption. After due consideration had been taken to ensure appropriate radiolabelling, image acquisition and processing procedures, a scintigraphic estimate of 26.2% (24.2-28.4%) was obtained, which did not significantly differ from the pharmacokinetic estimate of 26.4% (24.4-28.7%). In summary, pre-study validation of the radiolabelling technique, quality control of radioaerosols produced during the study, correction for re-distribution of radiolabel from the lungs, selection of regions of interest, assessment of lung contours, correction for tissue attenuation of gamma rays and establishment of the actual recovery of radioactivity in the scintigraphic measurements could potentially affect the accuracy of the scintigraphic estimate of pulmonary deposition and, thus, should be carefully considered in the design or evaluation of any such study. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inhalation, administration, radionuclide imaging, radioactive aerosol, technetium-99m, powder inhaler
in
International Journal of Pharmaceutics
volume
251
issue
1-2
pages
33 - 47
publisher
Elsevier
external identifiers
  • wos:000180950800004
  • pmid:12527173
  • scopus:0037472357
ISSN
1873-3476
DOI
10.1016/S0378-5173(02)00579-3
language
English
LU publication?
yes
id
745ff6ce-ef01-47c7-8f99-efb40c361918 (old id 318634)
date added to LUP
2007-08-24 14:50:24
date last changed
2018-01-07 05:13:33
@article{745ff6ce-ef01-47c7-8f99-efb40c361918,
  abstract     = {Methodological aspects of planar gamma scintigraphy used to quantify pulmonary aerosol deposition were investigated using an experimental dry powder formulation. Particles of micronized salbutamol sulphate were labelled with technetium-99m and admixed to an ordered mixture of unlabelled micronized salbutamol sulphate and larger carrier particles of lactose. The radioaerosol was administered to 24 healthy subjects, 12 in each of two consecutive, similarly designed studies. Pulmonary deposition was determined using two methods: repeated planar imaging, and pharmacokinetic assessments following charcoal co-administration to prevent gastrointestinal salbutamol absorption. After due consideration had been taken to ensure appropriate radiolabelling, image acquisition and processing procedures, a scintigraphic estimate of 26.2% (24.2-28.4%) was obtained, which did not significantly differ from the pharmacokinetic estimate of 26.4% (24.4-28.7%). In summary, pre-study validation of the radiolabelling technique, quality control of radioaerosols produced during the study, correction for re-distribution of radiolabel from the lungs, selection of regions of interest, assessment of lung contours, correction for tissue attenuation of gamma rays and establishment of the actual recovery of radioactivity in the scintigraphic measurements could potentially affect the accuracy of the scintigraphic estimate of pulmonary deposition and, thus, should be carefully considered in the design or evaluation of any such study.},
  author       = {Bondesson, Eva and Bengtsson, T and Borgstrom, L and Nilsson, L and Norrgren, Kristina and Trofast, E and Wollmer, Per},
  issn         = {1873-3476},
  keyword      = {inhalation,administration,radionuclide imaging,radioactive aerosol,technetium-99m,powder inhaler},
  language     = {eng},
  number       = {1-2},
  pages        = {33--47},
  publisher    = {Elsevier},
  series       = {International Journal of Pharmaceutics},
  title        = {Planar gamma scintigraphy - points to consider when quantifying pulmonary dry powder aerosol deposition},
  url          = {http://dx.doi.org/10.1016/S0378-5173(02)00579-3},
  volume       = {251},
  year         = {2003},
}