Advanced

Experimental results from a preclinical X-ray phase-contrast CT scanner

Tapfer, Arne; Bech, Martin LU ; Velroyen, Astrid; Meiser, Jan; Mohr, Juergen; Walter, Marco; Schulz, Joachim; Pauwels, Bart; Bruyndonckx, Peter and Liu, Xuan, et al. (2012) In Proceedings of the National Academy of Sciences 109(39). p.15691-15696
Abstract
To explore the future clinical potential of improved soft-tissue visibility with grating-based X-ray phase contrast (PC), we have developed a first preclinical computed tomography (CT) scanner featuring a rotating gantry. The main challenge in the transition from previous bench-top systems to a preclinical scanner are phase artifacts that are caused by minimal changes in the grating alignment during gantry rotation. In this paper, we present the first experimental results from the system together with an adaptive phase recovery method that corrects for these phase artifacts. Using this method, we show that the scanner can recover quantitatively accurate Hounsfield units in attenuation and phase. Moreover, we present a first tomography scan... (More)
To explore the future clinical potential of improved soft-tissue visibility with grating-based X-ray phase contrast (PC), we have developed a first preclinical computed tomography (CT) scanner featuring a rotating gantry. The main challenge in the transition from previous bench-top systems to a preclinical scanner are phase artifacts that are caused by minimal changes in the grating alignment during gantry rotation. In this paper, we present the first experimental results from the system together with an adaptive phase recovery method that corrects for these phase artifacts. Using this method, we show that the scanner can recover quantitatively accurate Hounsfield units in attenuation and phase. Moreover, we present a first tomography scan of biological tissue with complementary information in attenuation and phase contrast. The present study hence demonstrates the feasibility of grating-based phase contrast with a rotating gantry for the first time and paves the way for future in vivo studies on small animal disease models (in the mid-term future) and human diagnostics applications (in the long-term future). (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
differential X-ray phase contrast, grating interferometer, X-ray imaging
in
Proceedings of the National Academy of Sciences
volume
109
issue
39
pages
15691 - 15696
publisher
National Acad Sciences
external identifiers
  • wos:000309604500039
  • scopus:84866846530
ISSN
1091-6490
DOI
10.1073/pnas.1207503109
language
English
LU publication?
yes
id
c9268fd1-3341-48af-9443-237680de2ae4 (old id 3187550)
date added to LUP
2012-12-03 06:57:14
date last changed
2017-10-01 03:26:23
@article{c9268fd1-3341-48af-9443-237680de2ae4,
  abstract     = {To explore the future clinical potential of improved soft-tissue visibility with grating-based X-ray phase contrast (PC), we have developed a first preclinical computed tomography (CT) scanner featuring a rotating gantry. The main challenge in the transition from previous bench-top systems to a preclinical scanner are phase artifacts that are caused by minimal changes in the grating alignment during gantry rotation. In this paper, we present the first experimental results from the system together with an adaptive phase recovery method that corrects for these phase artifacts. Using this method, we show that the scanner can recover quantitatively accurate Hounsfield units in attenuation and phase. Moreover, we present a first tomography scan of biological tissue with complementary information in attenuation and phase contrast. The present study hence demonstrates the feasibility of grating-based phase contrast with a rotating gantry for the first time and paves the way for future in vivo studies on small animal disease models (in the mid-term future) and human diagnostics applications (in the long-term future).},
  author       = {Tapfer, Arne and Bech, Martin and Velroyen, Astrid and Meiser, Jan and Mohr, Juergen and Walter, Marco and Schulz, Joachim and Pauwels, Bart and Bruyndonckx, Peter and Liu, Xuan and Sasov, Alexander and Pfeiffer, Franz},
  issn         = {1091-6490},
  keyword      = {differential X-ray phase contrast,grating interferometer,X-ray imaging},
  language     = {eng},
  number       = {39},
  pages        = {15691--15696},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Experimental results from a preclinical X-ray phase-contrast CT scanner},
  url          = {http://dx.doi.org/10.1073/pnas.1207503109},
  volume       = {109},
  year         = {2012},
}