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Mass transfer resistance in a liquid-phase microextraction employing a single hollow fiber under unsteady-state conditions

Kumric, Ksenija R.; Vladisavljevic, Goran T.; Dordevic, Jelena S.; Jönsson, Jan Åke LU and Trtic-Petrovic, Tatjana M. (2012) In Journal of Separation Science 35(18). p.2390-2398
Abstract
In this study, the mass transport resistance in liquid-phase microextraction (LPME) in a single hollow fiber was investigated. A mathematical model has been developed for the determination of the overall mass transfer coefficient based on the acceptor phase in an unsteady state. The overall mass transfer coefficient in LPME in a single hollow fiber has been estimated from time-dependent concentration of extracted analyte in the acceptor phase while maintaining a constant analyte concentration in the donor phase. It can be achieved either using a high volume of donor to acceptor phase ratio or tuning the extraction conditions to obtain a low-enrichment factor, so that the analyte concentration in the sample is not significantly influenced... (More)
In this study, the mass transport resistance in liquid-phase microextraction (LPME) in a single hollow fiber was investigated. A mathematical model has been developed for the determination of the overall mass transfer coefficient based on the acceptor phase in an unsteady state. The overall mass transfer coefficient in LPME in a single hollow fiber has been estimated from time-dependent concentration of extracted analyte in the acceptor phase while maintaining a constant analyte concentration in the donor phase. It can be achieved either using a high volume of donor to acceptor phase ratio or tuning the extraction conditions to obtain a low-enrichment factor, so that the analyte concentration in the sample is not significantly influenced by the mass transfer. Two extraction systems have been used to test experimentally the developed model: the extraction of Lu(III) from a buffer solution and the extraction of three local anesthetics from a buffer or plasma solution. The mass transfer resistance, defined as a reciprocal values of the mass transfer coefficient, was found to be 1.2 x 103 cm-1 min for Lu(III) under optimal conditions and from 1.96 to 3.3 x 103 cm-1 min for the local anesthetics depending on the acceptor pH and the hydrophobicity of the drug. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hollow fiber liquid-phase microextraction, Mass transfer coefficient, Mass transfer resistance
in
Journal of Separation Science
volume
35
issue
18
pages
2390 - 2398
publisher
John Wiley & Sons
external identifiers
  • wos:000309059700005
  • scopus:84866504965
ISSN
1615-9314
DOI
10.1002/jssc.201200497
language
English
LU publication?
yes
id
5ce7a1d2-ff78-42b3-b17b-a003cf412dd3 (old id 3188036)
date added to LUP
2012-12-06 11:56:49
date last changed
2017-10-01 03:29:43
@article{5ce7a1d2-ff78-42b3-b17b-a003cf412dd3,
  abstract     = {In this study, the mass transport resistance in liquid-phase microextraction (LPME) in a single hollow fiber was investigated. A mathematical model has been developed for the determination of the overall mass transfer coefficient based on the acceptor phase in an unsteady state. The overall mass transfer coefficient in LPME in a single hollow fiber has been estimated from time-dependent concentration of extracted analyte in the acceptor phase while maintaining a constant analyte concentration in the donor phase. It can be achieved either using a high volume of donor to acceptor phase ratio or tuning the extraction conditions to obtain a low-enrichment factor, so that the analyte concentration in the sample is not significantly influenced by the mass transfer. Two extraction systems have been used to test experimentally the developed model: the extraction of Lu(III) from a buffer solution and the extraction of three local anesthetics from a buffer or plasma solution. The mass transfer resistance, defined as a reciprocal values of the mass transfer coefficient, was found to be 1.2 x 103 cm-1 min for Lu(III) under optimal conditions and from 1.96 to 3.3 x 103 cm-1 min for the local anesthetics depending on the acceptor pH and the hydrophobicity of the drug.},
  author       = {Kumric, Ksenija R. and Vladisavljevic, Goran T. and Dordevic, Jelena S. and Jönsson, Jan Åke and Trtic-Petrovic, Tatjana M.},
  issn         = {1615-9314},
  keyword      = {Hollow fiber liquid-phase microextraction,Mass transfer coefficient,Mass transfer resistance},
  language     = {eng},
  number       = {18},
  pages        = {2390--2398},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Separation Science},
  title        = {Mass transfer resistance in a liquid-phase microextraction employing a single hollow fiber under unsteady-state conditions},
  url          = {http://dx.doi.org/10.1002/jssc.201200497},
  volume       = {35},
  year         = {2012},
}