Comparison of two extraction methods for the determination of selective serotonin reuptake inhibitors in sewage sludge by hollow fiber liquid-phase microextraction
(2012) In Journal of Separation Science 35(18). p.2460-2468- Abstract
- This paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (HF-LPME). First, direct HF-LPME was used for extraction, clean-up, and preconcentration. The pharmaceuticals were extracted from slurry samples into an organic phase and then back-extracted into an aqueous phase in the lumen of the hollow fiber. Second, a procedure combining pressurized hot water extraction and HF-LPME for clean-up and preconcentration was developed for the same analytes and matrix. The extracts were subsequently analyzed by liquid chromatographymass... (More)
- This paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (HF-LPME). First, direct HF-LPME was used for extraction, clean-up, and preconcentration. The pharmaceuticals were extracted from slurry samples into an organic phase and then back-extracted into an aqueous phase in the lumen of the hollow fiber. Second, a procedure combining pressurized hot water extraction and HF-LPME for clean-up and preconcentration was developed for the same analytes and matrix. The extracts were subsequently analyzed by liquid chromatographymass spectrometry. For direct HF-LPME, limits of detection were between 1 and 12 ng g-1 (dry weight) and the relative standard deviation (RSD) values were 312%. For the second method, limits of detection were approximately 6 ng g-1 for all the compounds and RSD values were 812%. The methods were validated by comparison of results for the same samples. Sewage sludge from a Swedish wastewater treatment plant was analyzed by both methods; average concentrations were similar for citalopram, paroxetine, and fluoxetine with values of approximately 530, 40, and 200 ng g-1, respectively. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3188043
- author
- Sagrista, Ester ; Manuel Cortes, Jose ; Larsson, Estelle LU ; Salvado, Victoria ; Hidalgo, Manuela and Jönsson, Jan Åke LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hollow fiber liquid-phase microextraction, Pressurized hot water, extraction, Selective serotonin reuptake inhibitors, Sewage sludge
- in
- Journal of Separation Science
- volume
- 35
- issue
- 18
- pages
- 2460 - 2468
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000309059700014
- scopus:84866485967
- pmid:22753317
- ISSN
- 1615-9314
- DOI
- 10.1002/jssc.201200257
- language
- English
- LU publication?
- yes
- id
- 6ca978f9-200c-4b6e-94a0-98149617d164 (old id 3188043)
- date added to LUP
- 2016-04-01 09:50:07
- date last changed
- 2022-02-17 03:44:15
@article{6ca978f9-200c-4b6e-94a0-98149617d164, abstract = {{This paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (HF-LPME). First, direct HF-LPME was used for extraction, clean-up, and preconcentration. The pharmaceuticals were extracted from slurry samples into an organic phase and then back-extracted into an aqueous phase in the lumen of the hollow fiber. Second, a procedure combining pressurized hot water extraction and HF-LPME for clean-up and preconcentration was developed for the same analytes and matrix. The extracts were subsequently analyzed by liquid chromatographymass spectrometry. For direct HF-LPME, limits of detection were between 1 and 12 ng g-1 (dry weight) and the relative standard deviation (RSD) values were 312%. For the second method, limits of detection were approximately 6 ng g-1 for all the compounds and RSD values were 812%. The methods were validated by comparison of results for the same samples. Sewage sludge from a Swedish wastewater treatment plant was analyzed by both methods; average concentrations were similar for citalopram, paroxetine, and fluoxetine with values of approximately 530, 40, and 200 ng g-1, respectively.}}, author = {{Sagrista, Ester and Manuel Cortes, Jose and Larsson, Estelle and Salvado, Victoria and Hidalgo, Manuela and Jönsson, Jan Åke}}, issn = {{1615-9314}}, keywords = {{Hollow fiber liquid-phase microextraction; Pressurized hot water; extraction; Selective serotonin reuptake inhibitors; Sewage sludge}}, language = {{eng}}, number = {{18}}, pages = {{2460--2468}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Separation Science}}, title = {{Comparison of two extraction methods for the determination of selective serotonin reuptake inhibitors in sewage sludge by hollow fiber liquid-phase microextraction}}, url = {{http://dx.doi.org/10.1002/jssc.201200257}}, doi = {{10.1002/jssc.201200257}}, volume = {{35}}, year = {{2012}}, }