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Comparison of two extraction methods for the determination of selective serotonin reuptake inhibitors in sewage sludge by hollow fiber liquid-phase microextraction

Sagrista, Ester; Manuel Cortes, Jose; Larsson, Estelle LU ; Salvado, Victoria; Hidalgo, Manuela and Jönsson, Jan Åke LU (2012) In Journal of Separation Science 35(18). p.2460-2468
Abstract
This paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (HF-LPME). First, direct HF-LPME was used for extraction, clean-up, and preconcentration. The pharmaceuticals were extracted from slurry samples into an organic phase and then back-extracted into an aqueous phase in the lumen of the hollow fiber. Second, a procedure combining pressurized hot water extraction and HF-LPME for clean-up and preconcentration was developed for the same analytes and matrix. The extracts were subsequently analyzed by liquid chromatographymass... (More)
This paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (HF-LPME). First, direct HF-LPME was used for extraction, clean-up, and preconcentration. The pharmaceuticals were extracted from slurry samples into an organic phase and then back-extracted into an aqueous phase in the lumen of the hollow fiber. Second, a procedure combining pressurized hot water extraction and HF-LPME for clean-up and preconcentration was developed for the same analytes and matrix. The extracts were subsequently analyzed by liquid chromatographymass spectrometry. For direct HF-LPME, limits of detection were between 1 and 12 ng g-1 (dry weight) and the relative standard deviation (RSD) values were 312%. For the second method, limits of detection were approximately 6 ng g-1 for all the compounds and RSD values were 812%. The methods were validated by comparison of results for the same samples. Sewage sludge from a Swedish wastewater treatment plant was analyzed by both methods; average concentrations were similar for citalopram, paroxetine, and fluoxetine with values of approximately 530, 40, and 200 ng g-1, respectively. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hollow fiber liquid-phase microextraction, Pressurized hot water, extraction, Selective serotonin reuptake inhibitors, Sewage sludge
in
Journal of Separation Science
volume
35
issue
18
pages
2460 - 2468
publisher
John Wiley & Sons
external identifiers
  • wos:000309059700014
  • scopus:84866485967
ISSN
1615-9314
DOI
10.1002/jssc.201200257
language
English
LU publication?
yes
id
6ca978f9-200c-4b6e-94a0-98149617d164 (old id 3188043)
date added to LUP
2012-12-06 11:07:35
date last changed
2017-10-01 03:00:55
@article{6ca978f9-200c-4b6e-94a0-98149617d164,
  abstract     = {This paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (HF-LPME). First, direct HF-LPME was used for extraction, clean-up, and preconcentration. The pharmaceuticals were extracted from slurry samples into an organic phase and then back-extracted into an aqueous phase in the lumen of the hollow fiber. Second, a procedure combining pressurized hot water extraction and HF-LPME for clean-up and preconcentration was developed for the same analytes and matrix. The extracts were subsequently analyzed by liquid chromatographymass spectrometry. For direct HF-LPME, limits of detection were between 1 and 12 ng g-1 (dry weight) and the relative standard deviation (RSD) values were 312%. For the second method, limits of detection were approximately 6 ng g-1 for all the compounds and RSD values were 812%. The methods were validated by comparison of results for the same samples. Sewage sludge from a Swedish wastewater treatment plant was analyzed by both methods; average concentrations were similar for citalopram, paroxetine, and fluoxetine with values of approximately 530, 40, and 200 ng g-1, respectively.},
  author       = {Sagrista, Ester and Manuel Cortes, Jose and Larsson, Estelle and Salvado, Victoria and Hidalgo, Manuela and Jönsson, Jan Åke},
  issn         = {1615-9314},
  keyword      = {Hollow fiber liquid-phase microextraction,Pressurized hot water,extraction,Selective serotonin reuptake inhibitors,Sewage sludge},
  language     = {eng},
  number       = {18},
  pages        = {2460--2468},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Separation Science},
  title        = {Comparison of two extraction methods for the determination of selective serotonin reuptake inhibitors in sewage sludge by hollow fiber liquid-phase microextraction},
  url          = {http://dx.doi.org/10.1002/jssc.201200257},
  volume       = {35},
  year         = {2012},
}