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Influence of cell-to-cell variability on spatial pattern formation

Greese, Bettina LU ; Wester, K.; Bensch, R.; Ronneberger, O.; Timmer, J.; Huelskamp, M. and Fleck, C. (2012) In IET Systems Biology 6(4). p.143-153
Abstract
Many spatial patterns in biology arise through differentiation of selected cells within a tissue, which is regulated by a genetic network. This is specified by its structure, parameterisation and the noise on its components and reactions. The latter, in particular, is not well examined because it is rather difficult to trace. The authors use suitable local mathematical measures based on the Voronoi diagram of experimentally determined positions of epidermal plant hairs (trichomes) to examine the variability or noise in pattern formation. Although trichome initiation is a highly regulated process, the authors show that the experimentally observed trichome pattern is substantially disturbed by cell-to-cell variations. Using computer... (More)
Many spatial patterns in biology arise through differentiation of selected cells within a tissue, which is regulated by a genetic network. This is specified by its structure, parameterisation and the noise on its components and reactions. The latter, in particular, is not well examined because it is rather difficult to trace. The authors use suitable local mathematical measures based on the Voronoi diagram of experimentally determined positions of epidermal plant hairs (trichomes) to examine the variability or noise in pattern formation. Although trichome initiation is a highly regulated process, the authors show that the experimentally observed trichome pattern is substantially disturbed by cell-to-cell variations. Using computer simulations, they find that the rates concerning the availability of the protein complex that triggers trichome formation plays a significant role in noise-induced variations of the pattern. The focus on the effects of cell noise yields further insights into pattern formation of trichomes. The authors expect that similar strategies can contribute to the understanding of other differentiation processes by elucidating the role of naturally occurring fluctuations in the concentration of cellular components or their properties. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
IET Systems Biology
volume
6
issue
4
pages
143 - 153
publisher
Institution of Engineering and Technology
external identifiers
  • wos:000309513700006
  • scopus:84867134242
ISSN
1751-8857
DOI
10.1049/iet-syb.2011.0050
language
English
LU publication?
yes
id
c968fed7-17bb-48f2-a620-cb66235d6e75 (old id 3188112)
date added to LUP
2012-12-06 11:05:50
date last changed
2017-05-21 03:50:29
@article{c968fed7-17bb-48f2-a620-cb66235d6e75,
  abstract     = {Many spatial patterns in biology arise through differentiation of selected cells within a tissue, which is regulated by a genetic network. This is specified by its structure, parameterisation and the noise on its components and reactions. The latter, in particular, is not well examined because it is rather difficult to trace. The authors use suitable local mathematical measures based on the Voronoi diagram of experimentally determined positions of epidermal plant hairs (trichomes) to examine the variability or noise in pattern formation. Although trichome initiation is a highly regulated process, the authors show that the experimentally observed trichome pattern is substantially disturbed by cell-to-cell variations. Using computer simulations, they find that the rates concerning the availability of the protein complex that triggers trichome formation plays a significant role in noise-induced variations of the pattern. The focus on the effects of cell noise yields further insights into pattern formation of trichomes. The authors expect that similar strategies can contribute to the understanding of other differentiation processes by elucidating the role of naturally occurring fluctuations in the concentration of cellular components or their properties.},
  author       = {Greese, Bettina and Wester, K. and Bensch, R. and Ronneberger, O. and Timmer, J. and Huelskamp, M. and Fleck, C.},
  issn         = {1751-8857},
  language     = {eng},
  number       = {4},
  pages        = {143--153},
  publisher    = {Institution of Engineering and Technology},
  series       = {IET Systems Biology},
  title        = {Influence of cell-to-cell variability on spatial pattern formation},
  url          = {http://dx.doi.org/10.1049/iet-syb.2011.0050},
  volume       = {6},
  year         = {2012},
}