Conserved and Quickly Evolving Immunome Genes Have Different Evolutionary Paths
(2012) In Human Mutation 33(10). p.1456-1463- Abstract
- Genetic, transcript, and protein level variations have important functional and evolutionary consequences. We performed systematic data collection and analysis of copy-number variations, single-nucleotide polymorphisms, disease-causing variations, messenger RNA splicing variants, and protein posttranslational modifications for the genes and proteins essential for human immune system. Information about polymorphic and evolutionarily fixed genetic variations was used to group immunome genes to the most conserved and the most quickly changing ones under directed selection during the recent immunome evolution. Gene Ontology terms related to adaptive immunity are associated with gene groups subject to recent directing selection. In addition,... (More)
- Genetic, transcript, and protein level variations have important functional and evolutionary consequences. We performed systematic data collection and analysis of copy-number variations, single-nucleotide polymorphisms, disease-causing variations, messenger RNA splicing variants, and protein posttranslational modifications for the genes and proteins essential for human immune system. Information about polymorphic and evolutionarily fixed genetic variations was used to group immunome genes to the most conserved and the most quickly changing ones under directed selection during the recent immunome evolution. Gene Ontology terms related to adaptive immunity are associated with gene groups subject to recent directing selection. In addition, several other characteristics of the immunome genes and proteins in these two categories have statistically significant differences. The presented findings question the usability of directed mouse genes as models for human diseases and conditions and shed light on the fine tuning of human immunity and its diverse functions. HumMutat 33:1456-1463, 2012. (C) 2012 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3189916
- author
- Ortutay, Csaba and Vihinen, Mauno LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- human immune system, directed genes, conserved genes, animal disease, models
- in
- Human Mutation
- volume
- 33
- issue
- 10
- pages
- 1456 - 1463
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000308714500011
- pmid:22623381
- scopus:84866265570
- pmid:22623381
- ISSN
- 1059-7794
- DOI
- 10.1002/humu.22125
- language
- English
- LU publication?
- yes
- id
- a0f23031-0924-41a0-85ce-20e1210204b2 (old id 3189916)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22623381?dopt=Abstract
- date added to LUP
- 2016-04-01 11:10:35
- date last changed
- 2022-01-26 05:56:09
@article{a0f23031-0924-41a0-85ce-20e1210204b2, abstract = {{Genetic, transcript, and protein level variations have important functional and evolutionary consequences. We performed systematic data collection and analysis of copy-number variations, single-nucleotide polymorphisms, disease-causing variations, messenger RNA splicing variants, and protein posttranslational modifications for the genes and proteins essential for human immune system. Information about polymorphic and evolutionarily fixed genetic variations was used to group immunome genes to the most conserved and the most quickly changing ones under directed selection during the recent immunome evolution. Gene Ontology terms related to adaptive immunity are associated with gene groups subject to recent directing selection. In addition, several other characteristics of the immunome genes and proteins in these two categories have statistically significant differences. The presented findings question the usability of directed mouse genes as models for human diseases and conditions and shed light on the fine tuning of human immunity and its diverse functions. HumMutat 33:1456-1463, 2012. (C) 2012 Wiley Periodicals, Inc.}}, author = {{Ortutay, Csaba and Vihinen, Mauno}}, issn = {{1059-7794}}, keywords = {{human immune system; directed genes; conserved genes; animal disease; models}}, language = {{eng}}, number = {{10}}, pages = {{1456--1463}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Human Mutation}}, title = {{Conserved and Quickly Evolving Immunome Genes Have Different Evolutionary Paths}}, url = {{http://dx.doi.org/10.1002/humu.22125}}, doi = {{10.1002/humu.22125}}, volume = {{33}}, year = {{2012}}, }