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Conserved and Quickly Evolving Immunome Genes Have Different Evolutionary Paths

Ortutay, Csaba and Vihinen, Mauno LU (2012) In Human Mutation 33(10). p.1456-1463
Abstract
Genetic, transcript, and protein level variations have important functional and evolutionary consequences. We performed systematic data collection and analysis of copy-number variations, single-nucleotide polymorphisms, disease-causing variations, messenger RNA splicing variants, and protein posttranslational modifications for the genes and proteins essential for human immune system. Information about polymorphic and evolutionarily fixed genetic variations was used to group immunome genes to the most conserved and the most quickly changing ones under directed selection during the recent immunome evolution. Gene Ontology terms related to adaptive immunity are associated with gene groups subject to recent directing selection. In addition,... (More)
Genetic, transcript, and protein level variations have important functional and evolutionary consequences. We performed systematic data collection and analysis of copy-number variations, single-nucleotide polymorphisms, disease-causing variations, messenger RNA splicing variants, and protein posttranslational modifications for the genes and proteins essential for human immune system. Information about polymorphic and evolutionarily fixed genetic variations was used to group immunome genes to the most conserved and the most quickly changing ones under directed selection during the recent immunome evolution. Gene Ontology terms related to adaptive immunity are associated with gene groups subject to recent directing selection. In addition, several other characteristics of the immunome genes and proteins in these two categories have statistically significant differences. The presented findings question the usability of directed mouse genes as models for human diseases and conditions and shed light on the fine tuning of human immunity and its diverse functions. HumMutat 33:1456-1463, 2012. (C) 2012 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
human immune system, directed genes, conserved genes, animal disease, models
in
Human Mutation
volume
33
issue
10
pages
1456 - 1463
publisher
John Wiley & Sons
external identifiers
  • wos:000308714500011
  • pmid:22623381
  • scopus:84866265570
ISSN
1059-7794
DOI
10.1002/humu.22125
language
English
LU publication?
yes
id
a0f23031-0924-41a0-85ce-20e1210204b2 (old id 3189916)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22623381?dopt=Abstract
date added to LUP
2012-12-03 07:10:03
date last changed
2017-01-01 04:13:38
@article{a0f23031-0924-41a0-85ce-20e1210204b2,
  abstract     = {Genetic, transcript, and protein level variations have important functional and evolutionary consequences. We performed systematic data collection and analysis of copy-number variations, single-nucleotide polymorphisms, disease-causing variations, messenger RNA splicing variants, and protein posttranslational modifications for the genes and proteins essential for human immune system. Information about polymorphic and evolutionarily fixed genetic variations was used to group immunome genes to the most conserved and the most quickly changing ones under directed selection during the recent immunome evolution. Gene Ontology terms related to adaptive immunity are associated with gene groups subject to recent directing selection. In addition, several other characteristics of the immunome genes and proteins in these two categories have statistically significant differences. The presented findings question the usability of directed mouse genes as models for human diseases and conditions and shed light on the fine tuning of human immunity and its diverse functions. HumMutat 33:1456-1463, 2012. (C) 2012 Wiley Periodicals, Inc.},
  author       = {Ortutay, Csaba and Vihinen, Mauno},
  issn         = {1059-7794},
  keyword      = {human immune system,directed genes,conserved genes,animal disease,models},
  language     = {eng},
  number       = {10},
  pages        = {1456--1463},
  publisher    = {John Wiley & Sons},
  series       = {Human Mutation},
  title        = {Conserved and Quickly Evolving Immunome Genes Have Different Evolutionary Paths},
  url          = {http://dx.doi.org/10.1002/humu.22125},
  volume       = {33},
  year         = {2012},
}