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The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer

Haese, A; Graefen, M; Becker, Charlotte LU ; Noldus, J; Katz, J; Cagiannos, I; Kattan, M; Scardino, PT; Huland, E and Huland, H, et al. (2003) In The Prostate 54(3). p.181-186
Abstract
BACKGROUND. In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (Pca). In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa. METHODS. Serum levels of hK2, total and free prostate-specific antigens (PSA) were obtained one day before radical prostatectomy in 245 consecutive men. These were included with clinical stage and biopsy Gleason grade into univariate analysis and multivariate logistic regression models. RESULTS. pT2a/b PCa was found in n = 148 patients. In univariate analysis all preoperative... (More)
BACKGROUND. In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (Pca). In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa. METHODS. Serum levels of hK2, total and free prostate-specific antigens (PSA) were obtained one day before radical prostatectomy in 245 consecutive men. These were included with clinical stage and biopsy Gleason grade into univariate analysis and multivariate logistic regression models. RESULTS. pT2a/b PCa was found in n = 148 patients. In univariate analysis all preoperative parameters demonstrated significant association with the presence of pT2a/b PCa. Using multivariate logistic regression model hK2 (P = 0.022), clinical stage (P < 0.0001), and Gleason grade (P < 0.0001) were independent predictors of pT2a/b PCa whereas PSA (P = 0.3) was not. In bootstrap corrected logistic regression based nomograms the addition of hK2 density marginally enhanced predictive accuracy when PSA, PSA density, clinical stage, and Gleason grade were considered (AUC = 0.879 without hK2 density and 0.883 with hK2 density). CONCLUSIONS. hK2 and hK2 density could independently predict pT2a/b PCa. However, improvement in predictive accuracy was marginal when nomograms based on traditional variables were complemented with this serum marker. (C) 2002 Wiley-Liss, Inc. (Less)
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Contribution to journal
publication status
published
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keywords
cancer stage, biochemical predictors of prostate, hK2, prostate-specific antigen
in
The Prostate
volume
54
issue
3
pages
181 - 186
publisher
John Wiley & Sons
external identifiers
  • wos:000180542300002
  • pmid:12518322
  • scopus:0037441419
ISSN
0270-4137
DOI
language
English
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yes
id
2b0fe49a-5cf5-46b7-bfcf-9d5915f8ec51 (old id 319490)
date added to LUP
2007-09-03 13:35:41
date last changed
2018-06-17 03:48:32
@article{2b0fe49a-5cf5-46b7-bfcf-9d5915f8ec51,
  abstract     = {BACKGROUND. In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (Pca). In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa. METHODS. Serum levels of hK2, total and free prostate-specific antigens (PSA) were obtained one day before radical prostatectomy in 245 consecutive men. These were included with clinical stage and biopsy Gleason grade into univariate analysis and multivariate logistic regression models. RESULTS. pT2a/b PCa was found in n = 148 patients. In univariate analysis all preoperative parameters demonstrated significant association with the presence of pT2a/b PCa. Using multivariate logistic regression model hK2 (P = 0.022), clinical stage (P &lt; 0.0001), and Gleason grade (P &lt; 0.0001) were independent predictors of pT2a/b PCa whereas PSA (P = 0.3) was not. In bootstrap corrected logistic regression based nomograms the addition of hK2 density marginally enhanced predictive accuracy when PSA, PSA density, clinical stage, and Gleason grade were considered (AUC = 0.879 without hK2 density and 0.883 with hK2 density). CONCLUSIONS. hK2 and hK2 density could independently predict pT2a/b PCa. However, improvement in predictive accuracy was marginal when nomograms based on traditional variables were complemented with this serum marker. (C) 2002 Wiley-Liss, Inc.},
  author       = {Haese, A and Graefen, M and Becker, Charlotte and Noldus, J and Katz, J and Cagiannos, I and Kattan, M and Scardino, PT and Huland, E and Huland, H and Lilja, Hans},
  issn         = {0270-4137},
  keyword      = {cancer stage,biochemical predictors of prostate,hK2,prostate-specific antigen},
  language     = {eng},
  number       = {3},
  pages        = {181--186},
  publisher    = {John Wiley & Sons},
  series       = {The Prostate},
  title        = {The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer},
  url          = {http://dx.doi.org/},
  volume       = {54},
  year         = {2003},
}