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Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats

Meissner, Wassilios G.; Harnack, Daniel; Paul, Gesine LU ; Reum, Torsten; Sohr, Reinhard; Morgenstern, Rudolf and Kupsch, Andreas (2002) In Neuroscience Letters 328(2). p.8-105
Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are still unknown. In an attempt to elucidate those mechanisms, we have previously demonstrated that STN-DBS increases striatal extracellular dopamine (DA) metabolites in anaesthetized rats. PD being a movement disorder, it remains to be determined whether these findings are related to any relevant motor or behavioural changes. Thus, this study investigates concomitant behavioural changes during STN-DBS and extracellular striatal DA metabolites measured using microdialysis in freely moving 6-hydroxydopamine-lesioned rats. STN-DBS induced an increase of striatal DA metabolites in... (More)

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are still unknown. In an attempt to elucidate those mechanisms, we have previously demonstrated that STN-DBS increases striatal extracellular dopamine (DA) metabolites in anaesthetized rats. PD being a movement disorder, it remains to be determined whether these findings are related to any relevant motor or behavioural changes. Thus, this study investigates concomitant behavioural changes during STN-DBS and extracellular striatal DA metabolites measured using microdialysis in freely moving 6-hydroxydopamine-lesioned rats. STN-DBS induced an increase of striatal DA metabolites in awake, freely moving animals. Furthermore, we observed concomitant contralateral circling behaviour. Taken together, these results suggest that STN-DBS could disinhibit (consequently activate) substantia nigra compacta neurons via inhibition of gamma-aminobutyric acid-ergic substantia nigra reticulata neurons.

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published
keywords
3,4-Dihydroxyphenylacetic Acid, Animals, Cell Death, Disease Models, Animal, Dopamine, Electric Stimulation Therapy, Functional Laterality, Male, Neostriatum, Neural Pathways, Oxidopamine, Parkinsonian Disorders, Rats, Rats, Wistar, Rotation, Substantia Nigra, Subthalamic Nucleus, Sympatholytics, Tyrosine 3-Monooxygenase, Up-Regulation, Journal Article, Research Support, Non-U.S. Gov't
in
Neuroscience Letters
volume
328
issue
2
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0037047454
ISSN
0304-3940
language
English
LU publication?
no
id
31d433a7-9cbc-4867-bdaf-4ff88c9ddd33
date added to LUP
2017-05-18 12:37:21
date last changed
2017-12-10 05:08:37
@article{31d433a7-9cbc-4867-bdaf-4ff88c9ddd33,
  abstract     = {<p>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are still unknown. In an attempt to elucidate those mechanisms, we have previously demonstrated that STN-DBS increases striatal extracellular dopamine (DA) metabolites in anaesthetized rats. PD being a movement disorder, it remains to be determined whether these findings are related to any relevant motor or behavioural changes. Thus, this study investigates concomitant behavioural changes during STN-DBS and extracellular striatal DA metabolites measured using microdialysis in freely moving 6-hydroxydopamine-lesioned rats. STN-DBS induced an increase of striatal DA metabolites in awake, freely moving animals. Furthermore, we observed concomitant contralateral circling behaviour. Taken together, these results suggest that STN-DBS could disinhibit (consequently activate) substantia nigra compacta neurons via inhibition of gamma-aminobutyric acid-ergic substantia nigra reticulata neurons.</p>},
  author       = {Meissner, Wassilios G. and Harnack, Daniel and Paul, Gesine and Reum, Torsten and Sohr, Reinhard and Morgenstern, Rudolf and Kupsch, Andreas},
  issn         = {0304-3940},
  keyword      = {3,4-Dihydroxyphenylacetic Acid,Animals,Cell Death,Disease Models, Animal,Dopamine,Electric Stimulation Therapy,Functional Laterality,Male,Neostriatum,Neural Pathways,Oxidopamine,Parkinsonian Disorders,Rats,Rats, Wistar,Rotation,Substantia Nigra,Subthalamic Nucleus,Sympatholytics,Tyrosine 3-Monooxygenase,Up-Regulation,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {08},
  number       = {2},
  pages        = {8--105},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats},
  volume       = {328},
  year         = {2002},
}