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Time to pregnancy among partners of men exposed to di(2-ethylhexyl)phthalate

Modigh, C M; Bodin, S L V; Lillienberg, L; Dahlman-Hoglund, A; Åkesson, Bengt LU and Axelsson, G (2002) In Scandinavian Journal of Work, Environment and Health 28(6). p.418-428
Abstract
Objectives This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility. Methods Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from <0.1 to 2.1 mg/ml(3).... (More)
Objectives This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility. Methods Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from <0.1 to 2.1 mg/ml(3). The fathers of only four pregnancies had DEHP exposure of >0.5 mg/m(3) during the time to pregnancy. The pregnancies of employed women with unexposed partners or pregnancies of employed men unexposed during the time to pregnancy formed the reference group. Results The fecundability ratio for time to pregnancy was 1.07 [95% confidence interval (95% Cl) 0.84-1.351 for those with low exposure and 0.97 (95% CI 0.70-1.33) for the highly exposed after adjustment for the father's age, mother's age, and length of recall. When the analyses were restricted to first pregnancy, the fecundability ratio was 1.13 (95% Cl 0.83-1.56) for low exposure and 1.02 (95% Cl 0.66-1.59) for high exposure. Conclusions Time to pregnancy is not prolonged among couples with paternal exposure to DEHP at a mean exposure level of <0.5 mg/ml. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
plasticizer, occupational exposure, fecundity, males, reproduction
in
Scandinavian Journal of Work, Environment and Health
volume
28
issue
6
pages
418 - 428
publisher
Finnish Institute of Occupational Health
external identifiers
  • pmid:12539802
  • wos:000180289400007
  • scopus:0036961380
ISSN
0355-3140
language
English
LU publication?
yes
id
f62d694a-3876-44e6-baa4-593c55a9ba0a (old id 320072)
alternative location
http://www.sjweh.fi/show_abstract.php?abstract_id=694
date added to LUP
2007-11-02 12:13:37
date last changed
2017-01-01 05:05:32
@article{f62d694a-3876-44e6-baa4-593c55a9ba0a,
  abstract     = {Objectives This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility. Methods Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from &lt;0.1 to 2.1 mg/ml(3). The fathers of only four pregnancies had DEHP exposure of &gt;0.5 mg/m(3) during the time to pregnancy. The pregnancies of employed women with unexposed partners or pregnancies of employed men unexposed during the time to pregnancy formed the reference group. Results The fecundability ratio for time to pregnancy was 1.07 [95% confidence interval (95% Cl) 0.84-1.351 for those with low exposure and 0.97 (95% CI 0.70-1.33) for the highly exposed after adjustment for the father's age, mother's age, and length of recall. When the analyses were restricted to first pregnancy, the fecundability ratio was 1.13 (95% Cl 0.83-1.56) for low exposure and 1.02 (95% Cl 0.66-1.59) for high exposure. Conclusions Time to pregnancy is not prolonged among couples with paternal exposure to DEHP at a mean exposure level of &lt;0.5 mg/ml.},
  author       = {Modigh, C M and Bodin, S L V and Lillienberg, L and Dahlman-Hoglund, A and Åkesson, Bengt and Axelsson, G},
  issn         = {0355-3140},
  keyword      = {plasticizer,occupational exposure,fecundity,males,reproduction},
  language     = {eng},
  number       = {6},
  pages        = {418--428},
  publisher    = {Finnish Institute of Occupational Health},
  series       = {Scandinavian Journal of Work, Environment and Health},
  title        = {Time to pregnancy among partners of men exposed to di(2-ethylhexyl)phthalate},
  volume       = {28},
  year         = {2002},
}