Involvement of the serotonin system in L-dopa-induced dyskinesias
Carta, Manolo LU ; Carlsson, Thomas LU ; Muñoz, Ana LU ; Kirik, Deniz LU and Björklund, Anders LU
(2008)
In Parkinsonism and Related Disorders
14(Suppl 2).
p.8-154
- Abstract
The ability of L-dopa to relieve the motor impairments in Parkinson's disease patients declines over time, and side-effects, such as dyskinesias, appear--limiting the use of the drug in the advanced stage of the disease. Serotonergic neurons are able to convert L-dopa to dopamine and to store this neurotransmitter in synaptic vesicles. This peculiarity might be very important in the advanced disease, when most of the dopaminergic neurons have degenerated. Indeed, an increasing body of evidence points to dopamine released as a false neurotransmitter from the serotonin terminals as the main pre-synaptic determinant of L-dopa-induced dyskinesias in animal models of Parkinson's disease. These findings make the serotonin system an intriguing... (More)
The ability of L-dopa to relieve the motor impairments in Parkinson's disease patients declines over time, and side-effects, such as dyskinesias, appear--limiting the use of the drug in the advanced stage of the disease. Serotonergic neurons are able to convert L-dopa to dopamine and to store this neurotransmitter in synaptic vesicles. This peculiarity might be very important in the advanced disease, when most of the dopaminergic neurons have degenerated. Indeed, an increasing body of evidence points to dopamine released as a false neurotransmitter from the serotonin terminals as the main pre-synaptic determinant of L-dopa-induced dyskinesias in animal models of Parkinson's disease. These findings make the serotonin system an intriguing target for anti-dyskinetic therapies.
(Less)
- author
- Carta, Manolo
LU
; Carlsson, Thomas
LU
; Muñoz, Ana
LU
; Kirik, Deniz
LU
and Björklund, Anders
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Dopamine Agents, Dyskinesia, Drug-Induced, Humans, Levodopa, Serotonin, Journal Article, Research Support, Non-U.S. Gov't, Review
- in
- Parkinsonism and Related Disorders
- volume
- 14
- issue
- Suppl 2
- pages
- 8 - 154
- publisher
- Elsevier
- external identifiers
-
- pmid:18579429
- scopus:47049130578
- ISSN
- 1353-8020
- DOI
- 10.1016/j.parkreldis.2008.04.021
- language
- English
- LU publication?
- yes
- id
- 3201f509-3655-47d3-bfc7-385284a6113f
- date added to LUP
- 2016-11-23 14:16:11
- date last changed
- 2025-01-12 15:48:51
@article{3201f509-3655-47d3-bfc7-385284a6113f,
abstract = {{<p>The ability of L-dopa to relieve the motor impairments in Parkinson's disease patients declines over time, and side-effects, such as dyskinesias, appear--limiting the use of the drug in the advanced stage of the disease. Serotonergic neurons are able to convert L-dopa to dopamine and to store this neurotransmitter in synaptic vesicles. This peculiarity might be very important in the advanced disease, when most of the dopaminergic neurons have degenerated. Indeed, an increasing body of evidence points to dopamine released as a false neurotransmitter from the serotonin terminals as the main pre-synaptic determinant of L-dopa-induced dyskinesias in animal models of Parkinson's disease. These findings make the serotonin system an intriguing target for anti-dyskinetic therapies.</p>}},
author = {{Carta, Manolo and Carlsson, Thomas and Muñoz, Ana and Kirik, Deniz and Björklund, Anders}},
issn = {{1353-8020}},
keywords = {{Animals; Dopamine Agents; Dyskinesia, Drug-Induced; Humans; Levodopa; Serotonin; Journal Article; Research Support, Non-U.S. Gov't; Review}},
language = {{eng}},
number = {{Suppl 2}},
pages = {{8--154}},
publisher = {{Elsevier}},
series = {{Parkinsonism and Related Disorders}},
title = {{Involvement of the serotonin system in L-dopa-induced dyskinesias}},
url = {{http://dx.doi.org/10.1016/j.parkreldis.2008.04.021}},
doi = {{10.1016/j.parkreldis.2008.04.021}},
volume = {{14}},
year = {{2008}},
}